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Discovery of PSMA-Specific Peptide Ligands and Development of A Noncovalent Method to Attach Chemical Moieties to siRNA
(University of Missouri -- Kansas City, 2017)
The objective of this dissertation is to discover PSMA (Prostate Specific Membrane
Antigen)-specific peptide ligands using phage display and employ peptide nucleic acid as
a complementary linker to attach chemical ...
Peptide-Based Platform For Cancer Therapeutics And Drug Transportation Across Blood-Brain Barrier
(University of Missouri -- Kansas City, 2018)
Prostate cancer is the most common male malignancy and remains the second-leading
cause of death due to cancer in American men. While surgery and radiation are effective in
prostate cancer therapy at early stages, the ...
Discovery and Delivery of Peptide-Based Immune Checkpoint Inhibitors Targeting Pd-L1 for Cancer Immunotherapy
(2022)
The objective of this dissertation is to develop peptide-based immune checkpoint inhibitors that block the interaction between programmed cell death ligand-1 (PD-L1) and its receptor programmed cell death protein 1 (PD-1) ...