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Cytochrome P450 enzymes and oxidative stress in tobacco/nicotine mediated HIV pathogenesis
(2016)
In the US, the prevalence of cigarette smoking in the HIV-infected population is 50-70%
compared to 15-20% in the general population, which further increases the risk of smoking-related
health problems in this group. ...
Characterization of D-boroala as a novel Broad-spectrum antibacterial agent targeting D-Ala-D-Ala ligase & designer linkers : model reactions and linear free energy relationships in the reactivity and design of solid-phase linkers
(2014-07-18)
Bacterial infections were the major cause of death and morbidity prior to the development of modern antibiotics, and the increasing resistance of pathogenic bacteria to commonly used antibacterial agents is a major public ...
Establishing Metronidazole as a Novel Biomarker of CYP2A6 Activity
(University of Missouri -- Kansas City, 2018)
CYP2A6 is a polymorphically expressed enzyme with variation associated with
smoking behavior, cessation success, lung cancer risk, and differential drug exposure to
numerous medications including anti-infectious and ...
Preparation of Pentablock Nanomicellar Formulations for Prostate Cancer Drug Delivery Systems
(University of Missouri -- Kansas City, 2018)
This study is divided into three specific aims. Specific aim #1 focused on
synthesis of pentablock co-polymer using monomers of L-lactide, ε-caprolactone and
ethylene-glycol with varied molecular weights, (ii) ...