Embryonic Stem Cells (ESCs) are a critical tool for producing targeted knockout animals and understanding development. ESCs were successfully isolated from rats in 2008 and have been used in producing several targeted ...

Total joint replacement remains an excellent treatment for patients with debilitating joint degeneration. However, joint replacement using non-absorbable prostheses can deteriorate and become loose over time. A superior ...

growth factor beta (TGF[beta]). Non-surgical interventions allowing for the safe and complete clinical resolution of corneal fibrosis are currently lacking in physician and veterinary ophthalmology. In order to address this significant clinical need...

[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Spinal Muscular Atrophy is an autosomal recessive neuromuscular disorder that is the leading genetic cause of infant mortality. In humans, a nearly ...

Despite the accumulated understanding of the factors which affect passive transfer of colostral immunoglobulins and its recognized importance in dairy calves, approximately 35-40 % of US dairy calves have inadequate passive ...

provide powerful diagnostic DNA tests for dog breeders their veterinarians and but also provide spontaneously occurring canine models for human diseases. Since the first high quality dog genome reference sequence was published and made publically...

[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Yersinia pestis has been responsible for three major pandemics of plague, including the infamous Black Death that killed 250 million people in Europe. ...

This dissertation focuses on the use of whole genome sequencing (WGS) for the identification of disease causing variants in canine genomes. A brief review on the historical milestones of genetics, the creation and ...

Hyperthyroidism is a spontaneous disease that results in an abnormal elevation of circulating concentrations of one or more thyroid hormones. Despite being the most commonly diagnosed endocrine disorder of domestic cats, ...

Rodent models are invaluable tools to study the effects of differing gut microbiota (GM) on health and disease. Our laboratory has demonstrated that mouse GM profiles vary among animal vendors suggesting that subtle ...

[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Chronic hepatitis B virus (HBV) infection leads to liver disease, cirrhosis, and hepatocellular carcinoma. Globally, an estimated 50% of all hepatocellular ...

Bubonic plague infections begin in the dermis when the pathogen is introduced by a flea during a routine blood feed. Several barriers separate Yersinia pestis from its replicative niche, including phagocytic cells in the ...

[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The presence of arsenic and lead in the environment above the naturally occurring levels can have detrimental health effects on people living in these ...

Here we propose to develop a mouse model which will establish “proof of principle” for future development of large animal (e.g. pig) models which could be used as actual human solid organ and blood donors as well as in ...

[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The extreme virulence of Yersinia pestis in all three forms of plague disease is attributed to its multiple virulence factors. Y. pestis pathogenesis ...