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Transcriptome profiling of rattus norvegicus embryonic stem cells by RNA-sequencing
(University of Missouri--Columbia, 2014)
Embryonic Stem Cells (ESCs) are a critical tool for producing targeted knockout animals and understanding development. ESCs were successfully isolated from rats in 2008 and have been used in producing several targeted ...
The feasibility of interspecific rescue of endothelial/hematopoietic lineage deficiency
(University of Missouri--Columbia, 2012)
Here we propose to develop a mouse model which will establish “proof of principle” for future development of large animal (e.g. pig) models which could be used as actual human solid organ and blood donors as well as in ...
Characterization of interactions involving the polycystic kidney disease-causing proteins: SamCystin and Bicc1
(University of Missouri--Columbia, 2008)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Rodent models, including the Han:SPRD-Cy rat and the jcpk mouse, have been useful for identifying and characterizing genes that cause Polycystic Kidney ...
Characterization of the rat Atg16l1 gene and its role in autophagy and disease
(University of Missouri--Columbia, 2020)
Crohn's disease (CD) is a potentially life-threatening inflammatory condition of the gastrointestinal tract affecting approximately 1.6 million Americans. Previous studies confirm the important role of genetics in IBD. ...
Investigation of the biological role of the polycystic kidney disease protein bicaudal C (Bicc1) using comparative animal models
(University of Missouri--Columbia, 2009)
Polycystic kidney disease (PKD) is a common inherited disorder affecting 600,000 Americans and more than 12 million people worldwide. Clinical manifestations include renal enlargement, abnormal tubular development and ...