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Characterization of skeletal muscle in mouse models of osteogenesis imperfecta and myostatin deficiency
(University of Missouri--Columbia, 2010)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Osteogenesis imperfecta (OI) is a heritable connective tissue disorder hallmarked by bone fragility resulting primarily from mutations in the ...
Glomerulosclerosis in the Col1a2-deficient mouse model : homotrimer pathogenesis and MMP expression
(University of Missouri--Columbia, 2009)
The Col1a2-deficient (oim) mouse model exclusively synthesizes homotrimeric type I collagen due to the lack of functional pro [alpha] 2(I) collagen chains. The mouse develops a type I collagen glomerulopathy that has ...
Glomerular deposition of homotrimeric type I collagen in the COL1A2 deficient mouse
(University of Missouri--Columbia, 2006)
Type I collagen is the most abundant structural protein in the body. Type I collagen generally exists as a heterotrimeric protein; however, a homotrimeric isotype of type I collagen has been identified. Our lab currently ...
Role of Proa(2)I collagen chains and collagen crosslinking in thoracic aortic biochemical integrity during aging using the OIM mouse model
(University of Missouri--Columbia, 2006)
The extracellular matrix (ECM) is an important constituent for a variety of tissues including vascular tissue in which the ECM maintains aortic wall integrity. An important component of vascular tissue ECM is type I collagen. ...
The role of genetic background on the phenotypic severity of the osteogensis imperfecta murine (oim) COLIA2 gene mutation throughout postnatal development
(University of Missouri--Columbia, 2006)
Osteogenesis imperfecta (OI) is a diverse disease of type I collagen, the main structural protein in the body. It has been well documented that related individuals harboring the same OI-causing mutation can have very ...