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Development of biological hip resurfacing in dogs
(University of Missouri--Columbia, 2012)
Total joint replacement remains an excellent treatment for patients with debilitating joint degeneration. However, joint replacement using non-absorbable prostheses can deteriorate and become loose over time. A superior ...
Molecular genetics of spinal muscular atrophy : insights into various routes of therapeutic intervention
(University of Missouri--Columbia, 2009)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Spinal Muscular Atrophy is an autosomal recessive neuromuscular disorder that is the leading genetic cause of infant mortality. In humans, a nearly ...
Effect of colostral administration practices on serum immunoglobulin concentration in dairy calves
(University of Missouri--Columbia, 2008)
Despite the accumulated understanding of the factors which affect passive transfer of colostral immunoglobulins and its recognized importance in dairy calves, approximately 35-40 % of US dairy calves have inadequate passive ...
Molecular genetic studies in canine inherited diseases including neonatal cerebellar ataxia, degenerative myelopathy and multiple system degeneration
(University of Missouri--Columbia, 2013)
provide powerful diagnostic DNA tests for dog breeders their veterinarians and but also provide spontaneously occurring canine models for human diseases. Since the first high quality dog genome reference sequence was published and made publically...
Development of model systems for the vector-host-pathogen interface of bubonic plague
(University of Missouri--Columbia, 2013)
Bubonic plague infections begin in the dermis when the pathogen is introduced by a flea during a routine blood feed. Several barriers separate Yersinia pestis from its replicative niche, including phagocytic cells in the ...
Biodistribution of lead, arsenic, and gold nanoparticles following respiratory, oral and IV exposure of rats and swine
(University of Missouri--Columbia, 2008)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The presence of arsenic and lead in the environment above the naturally occurring levels can have detrimental health effects on people living in these ...
The evaluation of a bioactive biomaterial scaffold for the tissue engineering of articular cartilage
(University of Missouri--Columbia, 2011)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Bilayered tissue-engineered osteochondral (OC) grafts require the integration of two components; a superficial layer consisting of articular cartilage ...
Murine theiloviruses : characterization and pathogenesis of enteric and disseminated disease
(University of Missouri--Columbia, 2012)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Rat theilovirus (RTV), a member of the Theilovirus (ThV) species and closely related to Theiler's murine encephalomyelitis virus (TMEV), is a prevalent ...
The utility and limitations of the TRAMP model system for studying the effects of hedgehog targeted therapy in prostate cancer
(University of Missouri--Columbia, 2012)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Advanced prostate cancer has a very poor prognosis and no curative therapies. Understanding of the hedgehog (Hh) signaling pathway, a potential target ...
Characterization of the pigmentation locus in Yersinia pestis pathogenesis of pneumonic plague
(University of Missouri--Columbia, 2011)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The extreme virulence of Yersinia pestis in all three forms of plague disease is attributed to its multiple virulence factors. Y. pestis pathogenesis ...
The feasibility of interspecific rescue of endothelial/hematopoietic lineage deficiency
(University of Missouri--Columbia, 2012)
Here we propose to develop a mouse model which will establish “proof of principle” for future development of large animal (e.g. pig) models which could be used as actual human solid organ and blood donors as well as in ...
Kinetics of monocytotropic Ehrlichia infections, new insights from large animal models
(University of Missouri--Columbia, 2011)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Ehrlichia are tick-borne, obligate intracellular prokaryotic parasites found in host-derived parasitophorous vacuoles. The monocytotropic Erlichia ...
Universal blood : the life stream all four one and one for all : an enzymatic methodology creating a universal blood supply
(University of Missouri--Columbia, 2012)
α-NAGA (α-N-acetylgalactosaminidase) is an exoglycosidase that cleaves a specific carbohydrate, terminal linked 1-3 α-N-acetylgalactosamine, from the A antigen. The enzymatic hydrolysis creates the H antigen. This modification ...
Targeted 177 Lu antisense radiotherapy of B-cell non-Hodgkin's lymphoma
(University of Missouri--Columbia, 2011)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The B-cell lymphoma/leukemia-2 (bcl-2) proto-oncogene in non-Hodgkin's lymphoma (NHL) is a dominant inhibitor of apoptosis. The research goal was to ...
Use of the veterinary medical database to update the veterinary oncology literature
(University of Missouri--Columbia, 2009)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] In this dissertation we discuss the Veterinary Medical Database and how it can be used to perform epidemiological studies in the veterinary oncology field. We discuss many...
Characterization of interactions involving the polycystic kidney disease-causing proteins: SamCystin and Bicc1
(University of Missouri--Columbia, 2008)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Rodent models, including the Han:SPRD-Cy rat and the jcpk mouse, have been useful for identifying and characterizing genes that cause Polycystic Kidney ...
Mechanism of induction of vascular endothelial growth factor (vegf) in osteoarthritis
(University of Missouri--Columbia, 2006)
Vascular endothelial growth factor (VEGF) is an endothelial cell mitogen and an angiogenic factor. Angiogenesis regulated by VEGF is a critical event in the pathogenesis of Osteoarthritis (OA). Over-expression of VEGF in ...
Phylogenetic characterization of canine distemper viruses detected in naturally infected North American dogs
(University of Missouri--Columbia, 2006)
In 2004, dogs with clinical signs suggestive of viral disease known as canine distemper virus (CD) were referred to the University of Missouri Veterinary Diagnostic Laboratory for testing. From eleven such cases, a diagnosis of CD was confirmed...
Diagnosis, epidemiology and immunologic consequences of copper deficiency in calves
(University of Missouri--Columbia, 2006)
Copper is an essential micronutrient. Copper deficiency has been associated with disease states that decrease commercial beef production. Clinical manifestations of copper disease include anemia, diarrhea, long bone ...
Micro-imaging characterization of mouse models of metastasis
(University of Missouri--Columbia, 2005)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Non-invasive imaging techniques have been recently developed to characterize animal models of disease. The overarching hypothesis of this work explores ...