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Topical Clear Aqueous Nanomicellar Formulations For Anterior And Posterior Ocular Drug Delivery
(2015-08-04)
The objective of this study was to develop a clear, aqueous drug loaded
nanomicellar formulation (NMF) for the back-of-the-eye delivery. Hydrophobic
drugs such as cyclosporine, resolvin analog (RX-10045), dexamethasone ...
Topical Clear Aqueous Nanomicellar Formulation for Anterior and Posterior Ocular Drug Delivery
(University of Missouri–Kansas City, 2015)
The objective of this study was to develop a clear, aqueous drug loaded nanomicellar formulation (NMF) for the back-of-the-eye delivery. Hydrophobic drugs such as cyclosporine, resolvin analog (RX-10045), dexamethasone, ...
Preparation of Pentablock Nanomicellar Formulations for Prostate Cancer Drug Delivery Systems
(University of Missouri -- Kansas City, 2018)
This study is divided into three specific aims. Specific aim #1 focused on
synthesis of pentablock co-polymer using monomers of L-lactide, ε-caprolactone and
ethylene-glycol with varied molecular weights, (ii) ...
EVASION OF EFFLUX AND ENHANCING BIOAVAILABILITY OF AMPRENAVIR BY PRODRUG DERIVATIZATION
(2013)
Millions of people worldwide have been infected with human immunodeficiency (HIV). Highly active antiretroviral therapy (HAART) has substantially improved the clinical management of HIV-1 infection. Inclusion of HIV protease ...
Novel Transporter Targeted Lipid Ester Prodrugs of Cidofovir and Sustained Release Formulations for Cytomegalovirus Infection
(2013)
Cidofovir (CDF) has shown potential in vitro and in vivo antiviral activity against cytomegalovirus (CMV) retinitis. However, low CDF permeability due to its hydrophilic nature limits its effectiveness. Furthermore, ...
Topical Nanoparticulate Formulation of Drugs for Ocular Keratitis
(2015-08-11)
The primary objective of this project is to develop drug-loaded polymeric nanoparticles
suspended in a biocompatible gel for topical delivery of therapeutic agents commonly
employed in the treatment of ocular viral/bacterial ...
Development and evaluation of novel in situ depot-forming controlled release formulations
(University of Missouri--Kansas City, 2011-10-24)
Controlled drug delivery utilizing novel biodegradable and biocompatible pentablock copolymers could be a valuable strategy for the treatment of chronic eye diseases. In attempts to achieve controlled drug release, various ...
Novel Approaches for Targeted Delivery of Cancer Therapeutics to Nuclei of Malignant Cells
(University of Missouri--Kansas City, 2016)
The primary goal of this project is to increase specific uptake of anti-cancer therapeutics by
nuclei of cancer cells. A lot of research has been done to target therapeutics specifically across
plasma membrane of ...
Transporter-Targeted Prodrug Delivery to Improve Oral Bioavailability of Saquinavir
(2015-05-22)
Saquinavir (SQV) is the first antiretroviral protease inhibitor approved by Food and
Drug Administration in the United States for the treatment of HIV infection due to its
potent anti-HIV activity. However, some unfavorable ...
Clear, Aqueous Topical Nanomicelle Formulation For Diabetic Macula Edema
(University of Missouri -- Kansas City, 2018)
The objective of this study was to develop a clear aqueous mixed nanomicellar
formulation (NMF) of hydrophobic drugs for diabetic macula edema. The hydrophobic
drugs include triamcinolone acetonide (TA), fluocinolonce ...
Pentablock copolymers based controlled release formulations of small and macromolecules for ophthalmic applications
(University of Missouri--Kansas City, 2012)
Pentablock copolymers comprised of multi-polymer blocks such as polyethylene
glycol (PEG), polycaprolactone (PCL) and poly-lactide (PLA) were developed for
fabrication of nanoparticles and thermosensitive hydrogel ...
Novel targeted lipid prodrugs to improve cellular absorption of acyclovir and topical delivery to the eye via nanomicellar approach
(2013)
Biotinylated lipid prodrugs of acyclovir (ACV) were designed to target the
sodium dependent multivitamin transporter (SMVT) on the intestine and cornea to
facilitate ACV cellular transport. All the prodrugs were screened ...
Long Term Ocular Drug Delivery with Novel Pentablock Copolymers; Part I: Composite Nanoformulation of Macromolecules For Back of the Eye Diseases, Part II: Dexamethasone Nanoparticle to Develop an In Vitro Model for Glaucoma
(University of Missouri -- Kansas City, 2017)
Pentablock (PB) copolymers have been successfully synthesized for long term delivery in
the treatment of posterior segment ocular diseases. PB copolymers are comprised of FDA
approved biodegradable polymer such as ...
Part I: Effect of Nanomicelle Size on Trans-scleral Permeability of Dexamethasone and Part II: Strategies to Minimize Octreotide Acylation during Sustained Release from Biodegradable Polymers
(2015-06-19)
Our primary aim was to determine the effect of nanomicelle size on dexamethasone (DEX) transport across the sclera. Nanomicelles of various sizes were developed and characterized.
Low molecular weight diblock co-polymers, ...
Stereoisomeric Prodrugs to Improve Ocular And Oral Absorption of Prednisolone
(2015-08-11)
The primary objective of this project is to develop stereoisomeric prodrugs such as Lvaline-
D-valine-prednisolone (LDP) and D-valine-L-valine-prednisolone (DLP) to improve
ocular and oral absorption of prednisolone. ...
Prodrug Approach to Improve Oral and Brain Absorption of HIV Protease Inhibitor, Lopinavir
(2014)
The main objective of this project is to develop prodrug strategies to circumvent efflux
pumps such as P-glycoprotein (P-gp) and multidrug resistance associated proteins (MRPs),
thereby enhancing oral and brain absorption ...
Fomulation and Delivery of Drugs for Macular Edema and Retinoblastoma; Synthesis and In Vitro Characterization of Doxorubicin Loaded Surface Modified Nanoparticles Using PLGA-PEG-PLGA Polymer
(University of Missouri--Kansas City, 2011-01-20)
Macular edema (ME) is caused by central extravascular swelling of the macula resulting in a significant loss of visual activity. Corticosteroids are widely used in the treatment of ME. In this project, nanoparticles of ...
Development of polymeric nanoparticulate formulation encapsulating protein molecules following hydrophobic ion pairing complexation
(2014)
Several formulation strategies have been employed to enable sustained delivery of antibody therapeutics by nanoparticulate based dosage forms. However, development of sustained release nanoparticulate based dosage form for ...
Novel Folic Acid Targeted Nanomicelles For Delivery Of Hydrophobic Drugs To The Back Of The Eye
(University of Missouri -- Kansas City, 2019)
Overall aim of this research project is to develop folic acid targeted nanomicelles
loaded with insoluble hydrophobic drugs for delivery to posterior segment of the eye.
Retinoblastoma and uveitis are diseases that ...
Novel drug interaction for improving intracellular accumulation and efficacy of chemotherapeutics in retinoblastoma and mitochondrial localization of transporters in corneal epithelial cells
(University of Missouri--Kansas City, 2013-03-15)
Chemoreduction is the key treatment for retinoblastoma management. However, anticancer agents suffer from poor cell permeability and chemoresistance due to major interaction with multidrug resistant (MDR) efflux proteins ...