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Isotope harvesting from the beam dump cooling loop at the facility for rare isotope beams (FRIB)
(University of Missouri--Columbia, 2018)
column volumes of strong acid for elution. V was chosen as a radiotracer to determine the feasibility of using HFSLM extraction to remove short-lived transition metals from the beam dump loop. Part per trillion levels of 48V were successfully recovered...
Radionuclide production and separation techniques for radiopharmaceutical development and nuclear waste processing
(University of Missouri--Columbia, 2018)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] With increasing cancer incident rates and advancements in nuclear medicine, the demand for optimizing pathways to produce radionuclides or investigating ...
Arsenic-72, 77 as a matched pair radiopharmaceutical for imaging and radiotherapy
(University of Missouri--Columbia, 2018)
] The parameters for a 72Se/72As generator were evaluated and nca 72Se was produced via the 70Ge([alpha], 2n)72Se nuclear reaction, separated and loaded onto a generator column. Further evaluations are underway. Radiochemistry of nca 72,77As will be discussed...
Radioactive Au for potential radiotherapeutic application
(University of Missouri--Columbia, 2010)
Radioactive gold-198/199 can be used in therapeutic radiopharmaceutical agents to combat cancer. In this thesis, two projects involving the development of radioactive gold-198/199 are described. The first project discusses ...
Anisotropic shock response of 1,3,5-triamino-2,4,6-trinitrobenzene (TATB)
(University of Missouri--Columbia, 2020)
arise for other quantities that are also important in hotspot ignition and growth, for example, the skewness of high-temperature distributions and the local temperature field around the post-collapse hotspot, indicating the urgent need to incorporate...
Theranostic and matched pair radionuclides as radiopharmaceutical as for imaging and radiotherapy
(University of Missouri--Columbia, 2020)
The main focus of this dissertation is on the development of arsenic and rhenium radiopharmaceuticals as potential theranostic candidates. Chapter 2 focuses on 72,77. As radiopharmaceuticals for potential PET imaging and ...
Studies and synthetic methodology of Nampt inhibition
(University of Missouri--Columbia, 2018)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The purpose of this research is to study and synthesize an array of a highly potent pharmaceuticals that can selectively cause apoptosis in various ...
Novel techniques for cold/ultracold molecular collisions
(University of Missouri--Columbia, 2020)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] This thesis presents the successful implementation of a slice velocity map imaging apparatus capable of performing molecular beam scattering experiments ...
Synthethic pathways to multiple surface functionalization of polyhedral boranes
(University of Missouri--Columbia, 2019)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The chemistry of dodecahydro--closo--dodecaborate(2-), closo-[B12H12]2-, and decahydro-closo-decaborate(2-), [B10H10]2-, with different organic ...
Structural, biochemical, and inhibition studies of proline biosynthetic enzymes
(University of Missouri--Columbia, 2019)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Pyrroline-5-carboxylate reductase (PYCR) is the final enzyme in proline biosynthesis, catalyzing the NAD(P)H-dependent reduction of [Delta]1-pyrroli ...
Technetium and rhenium schiff base complexes for nuclear medicine
(University of Missouri--Columbia, 2019)
This dissertation investigates the synthesis of rhenium and technetium Schiff base complexes for potential applications in nuclear medicine. In Chapter 2, a series of mixed ligand Re(III) complexes of the form trans-[Re( ...
Quantum aspects of roaming dynamics
(University of Missouri--Columbia, 2020)
Decades of experimental and theoretical achievements built on the foundations of thermochemistry and quantum mechanics have birthed the field of molecular dynamics where intimate details of individual reactive events can ...
Development and application of inductively coupled plasma mass spectrometry techniques to investigate platinum chemotherapy agents
(University of Missouri--Columbia, 2010)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Cisplatin (cDDP), the first platinum chemotherapy compound, has been used in cancer chemotherapy in human beings and animals for more than thirty ...
Synthesis and preclinical evaluation of peptide receptor-targeted diagnostic and therapeutic radiopharmaceuticals for prostate cancer
(University of Missouri--Columbia, 2019)
The overexpression of certain peptide receptors on cancers cells can be exploited for the development of radiopharmaceuticals that are selectively delivered to cancer cells for diagnostic imaging or therapeutic purposes. ...
Evaluation for ammonium bifluoride dissolution for application to post-detonation nuclear forensics and rare Earth element extraction
(University of Missouri--Columbia, 2019)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] If a nuclear device were to be used in an act of terrorism, prompt nuclear forensic analysis of the post-detonation debris is crucial in order to ...
DNA interstrand crosslinks arising from DAN strand breaks at true abasic sites in duplex DNA
(University of Missouri--Columbia, 2018)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Abasic sites (apurinic/apyrimidinic sites, Ap sites) are one of the most common forms of lesions found in genomic DNA. For the past decade, Gates group ...
Development of radiolabeled metal chalcogenide nanoparticles for targeted adiotherapy against an infection
(University of Missouri--Columbia, 2018)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Targeted radiotherapy has been demonstrated to be therapeutic against infections with doses comparable to what a patient would receive for cancer ...
Investigation of CO2 capture systems, Lewis acid-base pairs, and oscillating reactions with electronic structure theory and kinetics-based approaches
(University of Missouri--Columbia, 2020)
Equilibrium is a key theme in chemistry education. Starting in high school and continuing in freshman general chemistry courses, STEM students have to learn the foundations of equilibria. What is the key concept of an ...
Stereoselective synthesis of seven-membered rings using intramolecular (4+3) cycloaddition reactions
(University of Missouri--Columbia, 2020)
Heterocyclic molecules containing seven-membered rings have importance in organic synthesis owing to their presence in some natural products and biologically active molecules. Furthermore, these scaffolds act as important ...
Investigating the bifunctional chelate approach for radiopharmaceutical development
(University of Missouri--Columbia, 2010)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Radiopharmaceuticals are drugs that contain a radioactive atom for the purpose of imaging or therapy of disease. The type of emission determines the ...