Search
Now showing items 1-5 of 5
The effects of structural modifications on sigma receptor binding
(University of Missouri--Columbia, 2007)
The sigma receptor is a unique receptor family that has two subtypes: sigma1 and sigma2. Sigma1 receptors are involved in several physiological functions such as psychosis and depression. Sigma2 receptors are expressed in ...
Investigation of the replacement of cysteine residues in DOTA-(Tyr³)-octreotate: synthesis, characterization and evaluation of biological activities
(University of Missouri--Columbia, 2006)
Modification of the peptide sequence of DOTA-Tyr³-octreotate is carried out by substituting the cysteine moieties with D-Cysteine, L-Penicillamine and D-Penicillamine in one or both positions to study the effect of this ...
Synthesis and evaluation of 105Rhodium(III) complexes derived from diaminodithioether (DADTE) ligands
(University of Missouri--Columbia, 2006)
Seven analogoues of tetradentate acyclic diaminodithioether (DADTE)ligands were synthesized and characterized. R₂SC(R₁)₂)CHnN(CH₂)mNCHn((R₁)₂C)SR₂ 222-gdm (L3): m = 1, n = 1, R₁ = -CH₃ and R₂ = -H; 222-gdm-pmBz (L4): m = ...
Synthesis and structure-activity relationship of a series of sigma receptor ligands
(University of Missouri--Columbia, 2007)
Sigma receptors are involved in several biological processes, and sigma ligands might be promising as cancer treatment agents, cocaine abuse medicines, and valuable psychiatric drugs. In an attempt to elucidate effectual ...
Studies on radiometal chelator-bombesin peptide-based radiopharmaceuticals for tumor GRP-receptor subtype mediated radioimaging
(University of Missouri--Columbia, 2007)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Bombesin-like peptides bind to gastrin-releasing peptide receptor subtype 2 (BB2) with significantly high binding affinity and specificity. In an ...