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Synthesis, self-assembly and applications of tribenzopenta-phene derivatives and triphenylene-based conjugated foldamers
(2013)
to dictate controlled self-assembly processes. In addition, the potentially high charge mobility along the stacked PAH column may find applications in sensors, field effect transistors and photovoltaic cells. In this dissertation, efficient synthetic...
Part I: The synthesis of chenodeoxycholic acid derived macrocyles and cage compounds. Part II. Sonogashira coupling for the synthesis of well-defined π-conjugated arylene ethynylene oligomers as blue-light-emitting materials
(University of Missouri--Kansas City, 2012-01-20)
The design and development of novel chenodeoxychoic acid (CDCA) derivatives and its molecular architecture was accomplished. A novel CDCA derivative with an ambient CO2 insertion to 7α-side chain has been serendipitously ...
Synthesis, morphologies and applications of polyoxometalate-containing diblock copolymers
(University of Missouri--Kansas City, 2012-01-31)
Block copolymers by virtue of their ability to self assemble and microphaseseparation
due to the contrast in chemical and physical properties of the covalently linked
blocks constitute the essential building blocks towards ...
Design, synthesis, characterization and photovoltaic applications of conjugated polymer hybrids containing coordinatively binded semiconducting nanocrystals
(2014-07-17)
Orgainc-inorganic hybrids containing organic conjugated polymers and inorganic semiconducting nanocrystals are fascinating optoelectronic materials which may combine the advantages of both worlds. This dissertation aims ...
EVASION OF EFFLUX AND ENHANCING BIOAVAILABILITY OF AMPRENAVIR BY PRODRUG DERIVATIZATION
(2013)
Millions of people worldwide have been infected with human immunodeficiency (HIV). Highly active antiretroviral therapy (HAART) has substantially improved the clinical management of HIV-1 infection. Inclusion of HIV protease ...
Design, synthesis and evaluation of novel intercalator analogs targeting therapeutically important polymerases and folded RNA
(2013)
Polymerases and ribonucleic acids have been found to play major roles in the
causation and progression of several diseases. Targeting such important therapeutic targets
using small molecules can help achieve their specific ...
Development and evaluation of novel in situ depot-forming controlled release formulations
(University of Missouri--Kansas City, 2011-10-24)
Controlled drug delivery utilizing novel biodegradable and biocompatible pentablock copolymers could be a valuable strategy for the treatment of chronic eye diseases. In attempts to achieve controlled drug release, various ...
Development of drug conjugates in cancer therapy and evaluation of dual siRNA silencing effect on breast cancer growth and invasion
(University of Missouri--Kansas City, 2012)
The objective of this dissertation is to present various approaches for treatment cancer,
which is the leading cause of death worldwide. Compared to other disease, cancer has many
unique biological characteristics that ...
Pentablock copolymers based controlled release formulations of small and macromolecules for ophthalmic applications
(University of Missouri--Kansas City, 2012)
Pentablock copolymers comprised of multi-polymer blocks such as polyethylene
glycol (PEG), polycaprolactone (PCL) and poly-lactide (PLA) were developed for
fabrication of nanoparticles and thermosensitive hydrogel ...
Novel targeted lipid prodrugs to improve cellular absorption of acyclovir and topical delivery to the eye via nanomicellar approach
(2013)
Biotinylated lipid prodrugs of acyclovir (ACV) were designed to target the
sodium dependent multivitamin transporter (SMVT) on the intestine and cornea to
facilitate ACV cellular transport. All the prodrugs were screened ...
Fomulation and Delivery of Drugs for Macular Edema and Retinoblastoma; Synthesis and In Vitro Characterization of Doxorubicin Loaded Surface Modified Nanoparticles Using PLGA-PEG-PLGA Polymer
(University of Missouri--Kansas City, 2011-01-20)
Macular edema (ME) is caused by central extravascular swelling of the macula resulting in a significant loss of visual activity. Corticosteroids are widely used in the treatment of ME. In this project, nanoparticles of ...
Structural and chemical studies of RNA as anti-cancer target and signaling molecule
(University of Missouri--Kansas City, 2012-01-06)
Ribonucleic acids have been found to have a major role in causation and propagation
of diseases. Targeting such therapeutically important RNA can be a method of treatment of
various diseases. Two such therapeutically ...
Structural and enzymatic characterization of bacterial cell wall enzymes: focus on penicillin-binding proteins
(2013)
The research presented in this dissertation was aimed at understanding several structural and biochemical features underlying the bacterial cell wall biosynthetic process using statistical, biochemical and analytical tools. ...
Evaluation of therapeutic effect of IKK epsilon SiRNA on breast cancer cells and development of a peptide-based SiRNA delivery system
(University of Missouri--Kansas City, 2012)
The objective of this dissertation is to develop siRNA-based cancer therapeutics. In
chapters 1 and 2, we introduced the mechanism, challenge and promise of RNAi-based
therapy, as well as various siRNA delivery systems. ...
Novel drug interaction for improving intracellular accumulation and efficacy of chemotherapeutics in retinoblastoma and mitochondrial localization of transporters in corneal epithelial cells
(University of Missouri--Kansas City, 2013-03-15)
Chemoreduction is the key treatment for retinoblastoma management. However, anticancer agents suffer from poor cell permeability and chemoresistance due to major interaction with multidrug resistant (MDR) efflux proteins ...
Design and optimization of nanoformulation loaded with HIV microbicides
(2013)
The objective of this dissertation is to design and optimize nanoformulation for microbicides intended for the prevention of HIV/AIDS transmission. In chapters 1 and 2, the aims and the scope of this work are introduced, ...
Formulation of nanoparticles encapsulating hydrophilic molecules following their ionic complexation
(University of Missouri--Kansas City, 2011-06-01)
Part 1: Dexamethasone is one of the most widely used drug molecules for the treatment of posterior segment ocular diseases. The major problems associated with the delivery of dexamethasone include its poor aqueous solubility ...
Development and characterization of advanced nitric oxide-delivering polymeric systems against cardiovascular complications
(2013)
Valvular complications and atherosclerosis contribute to the majority of the
cardiovascular disease related deaths worldwide. In this thesis project the role of
normative tissue mineral concentrations in native and ...
Improved delivery of molecularly targeted agents upon modulation of multidrug resistance efflux proteins at mouse blood brain barrier
(University of Missouri--Kansas City, 2012)
Recurrent brain tumors are one of the most lethal forms of solid tumors with poor
prognosis. Molecularly targeted therapy, inhibiting the tyrosine kinase domain of
epidermal growth factor receptor (EGFR), platelet derived ...
Nutrient Transporter targeted Delivery of HIV Protease Inhibitors
(University of Missouri--Kansas City, 2011-01-20)
HIV/AIDS has become one of the greatest threats to human health. Although inclusion of protease inhibitors (PIs) in HAART has greatly slowed the disease progression and improved the outcome of clinical treatment, the ...