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A comparison of methods of determining the amount of radium in rocks and minerals
(University of Missouri--Columbia, 1914)
This paper is chiefly the outcome of a study of the radioactivity of the rock at different depths from the surface obtained during the drilling of the University deep well number 2. The first method described by J. Joly ...
Isotope harvesting from the beam dump cooling loop at the facility for rare isotope beams (FRIB)
(University of Missouri--Columbia, 2018)
column volumes of strong acid for elution. V was chosen as a radiotracer to determine the feasibility of using HFSLM extraction to remove short-lived transition metals from the beam dump loop. Part per trillion levels of 48V were successfully recovered...
Radionuclide production and separation techniques for radiopharmaceutical development and nuclear waste processing
(University of Missouri--Columbia, 2018)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] With increasing cancer incident rates and advancements in nuclear medicine, the demand for optimizing pathways to produce radionuclides or investigating ...
Method development for the analysis of nuclear forensic signatures with ICP-MS
(University of Missouri--Columbia, 2022)
Nuclear forensic analysis is a field of analytical chemistry that focuses specifically on analyzing signatures of nuclear material for criminal investigation. Promising nuclear forensic signatures include rare earths element ...
Phosphinimines as potential technetium environmental sensors
(University of Missouri--Columbia, 2007)
Phosphinimines, R₃P=NSiMe₃, undergo hydrolysis to form the phosphiniminiumcation, R₃P=NH₂+, which forms the ion pair [R₃P=NH₂+][X-] in the presence of an anion.Preliminary studies show that in the presence of TcO₄-, ...
Low temperature reaction kinetics inside an extended Laval nozzle : REMPI characterization and detection by broadband rotational spectroscopy
(University of Missouri--Columbia, 2023)
") with the revolutionary Chirped-Pulse Fourier Transform Microwave Spectroscopy (CP-FTMW) method forming what has been dubbed CPUF (Chirped-Pulse/ Uniform Flow) has allowed just this to occur. A cold, uniform column of gas is obtained via the use of a Laval nozzle...
Arsenic-72, 77 as a matched pair radiopharmaceutical for imaging and radiotherapy
(University of Missouri--Columbia, 2018)
] The parameters for a 72Se/72As generator were evaluated and nca 72Se was produced via the 70Ge([alpha], 2n)72Se nuclear reaction, separated and loaded onto a generator column. Further evaluations are underway. Radiochemistry of nca 72,77As will be discussed...
Radioactive Au for potential radiotherapeutic application
(University of Missouri--Columbia, 2010)
Radioactive gold-198/199 can be used in therapeutic radiopharmaceutical agents to combat cancer. In this thesis, two projects involving the development of radioactive gold-198/199 are described. The first project discusses ...
Spectroscopic studies of transmembrane helical peptides and LC-MS/MS method development and validation for PFAS quantitation
(University of Missouri--Columbia, 2022)
Water hydrogen bonding (H-bonding) to [alpha]-helical transmembrane (TM) peptides is fundamental to understanding the behavior and function of [alpha]-helical peptides, disease pathways, and the development of new drugs. ...
Anisotropic shock response of 1,3,5-triamino-2,4,6-trinitrobenzene (TATB)
(University of Missouri--Columbia, 2020)
arise for other quantities that are also important in hotspot ignition and growth, for example, the skewness of high-temperature distributions and the local temperature field around the post-collapse hotspot, indicating the urgent need to incorporate...
Determination of total selenium and seleno-amino acids in yeast and aquatic organisms by liquid chromatography and inductively coupled plasma mass spectrometry
(University of Missouri--Columbia, 2007)
The primary goal of this dissertation research was to develop methods for routine speciation analysis of selenium in tissues. A method for total selenium using on-line stable isotope dilution analysis with conventional ...
Purification and characterization of A[beta] and probing the interactions between myricetin and A[beta] using various spectroscopic methods
(University of Missouri--Columbia, 2009)
[beta] fragments, A[beta](1-16) and A[beta](25-40), together with A[beta](1-42) were investigated. HPLC purification was conducted on crude A[beta](1-16) and A[beta](25-40) using a Beckman System Gold HPLC system, a Vydac C18 column and a combination...
Production of high specific activity rhenium-186 for radiotherapeutic applications and reformulation of a novel liquid brachytherapy agent
(University of Missouri--Columbia, 2022)
The continued development of methods for the production and separation of high specific activity (HSA) rhenium-186 (t1/2 = 90.64 h, Eb-ave = 359 keV (71 percent), 306 keV (22 percent)) would largely increase its use as a ...
Theranostic and matched pair radionuclides as radiopharmaceutical as for imaging and radiotherapy
(University of Missouri--Columbia, 2020)
The main focus of this dissertation is on the development of arsenic and rhenium radiopharmaceuticals as potential theranostic candidates. Chapter 2 focuses on 72,77. As radiopharmaceuticals for potential PET imaging and ...
Studies and synthetic methodology of Nampt inhibition
(University of Missouri--Columbia, 2018)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The purpose of this research is to study and synthesize an array of a highly potent pharmaceuticals that can selectively cause apoptosis in various ...
Inactivation of protein tyrosine phosphatases by endogenous and dietary agents
(University of Missouri--Columbia, 2009)
Protein tyrosine phosphatases are a class of enzymes that control a number of critical signaling pathways inside cells. We have discovered a number of dietary and endogenous agents that are capable of modifying these ...
Molecular dynamics simulations of shock-induced pore collapse in single crystal [beta]-HMX
(University of Missouri--Columbia, 2023)
This thesis presents all-atom classical molecular dynamics (MD) simulations of shock-wave passage across a pore-type defect in single-crystal [beta]-1,3,5,7-tetranitro-1,3,5,7-tetraocane ([beta]-HMX). The purpose of this ...
Novel techniques for cold/ultracold molecular collisions
(University of Missouri--Columbia, 2020)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] This thesis presents the successful implementation of a slice velocity map imaging apparatus capable of performing molecular beam scattering experiments ...
Synthesis of silyloxyacrolein for [4+3] cycloaddition and preparation of carbonate closomer
(University of Missouri--Columbia, 2008)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Followed by Funk's method, I synthesized silyloxyacroleins and used them as dienophiles to react with different dienes in [4+3] cycloaddition reaction. ...
Formation and properties of endogenous adducts and crosslinks generated by amine-catalyzed strand cleavage at an AP site in duplex DNA
(University of Missouri--Columbia, 2022)
Abasic sites in DNA are a very common lesion. They are formed spontaneously and in the presence of biological amines, enzymes, and proteins. If unrepaired, abasic sites lead to DNA strand breaks and crosslinks. This thesis ...