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Data mining and machine learning methods for chromosome conformation data analysis
(University of Missouri--Columbia, 2019)
Sixteen years after the sequencing of the human genome, the Human Genome Project (HGP), and 17 years after the introduction of Chromosome Conformation Capture (3C) technologies, three-dimensional (3-D) inference and big ...
Revealing the conformation and properties of human genome, protein molecules and protein domain co-occurrence network
(University of Missouri--Columbia, 2012)
Deoxyribonucleic acid, or DNA, encodes genetic instructions for the functionalities of organisms. For human beings, 23 pairs of chromosomes, containing DNA strands, form a globule structure in the nucleus. This chromosomal ...
Improving protein structure prediction by deep learning and computational optimization
(University of Missouri--Columbia, 2019)
Protein structure prediction is one of the most important scientific problems in the field of bioinformatics and computational biology. The availability of protein three-dimensional (3D) structure is crucial for studying ...