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Physiological and pharmacological characterization of the N1303K mutant CFTR
(University of Missouri--Columbia, 2018)
Background: N1303K, one of the common, severe disease-causing mutations in the CFTR gene, causes both defective biogenesis and gating abnormalities of the CFTR protein. The goals of the present study are to quantitatively ...
Unraveling the role of the endogenous complex gut microbiota in the Pirc rat model of human colon cancer
(University of Missouri--Columbia, 2018)
The gut microbiota (GM) has recently been shown to modulate several systemic conditions in human and model systems, most importantly in intestinal disorders. It has also been demonstrated to have significant impacts on ...
Monte Carlo neutronic simulations for a new approach to parametric INAA and Mo-99 production feasibility at MURR
(University of Missouri--Columbia, 2009)
A novel approach to parametric instrumental neutron activation analysis at MURR has been established. In particular, a detailed MCNP5 steady-state model of the MURR core was developed. The model, which was based on the ...
Development of Multibody Soft Tissue Models and Their Tuning to Experimental Data: With a Focus in the Canine Meniscus
(University of Missouri--Kansas City, 2010)
This study explores the application of multibody modeling techniques in an attempt to capture the flexible behavior of biological tissues inside of a rigid body mechanics software. To accomplish this, segmented multibody ...
Synthesis and structure-activity relationship of a series of sigma receptor ligands
(University of Missouri--Columbia, 2007)
Sigma receptors are involved in several biological processes, and sigma ligands might be promising as cancer treatment agents, cocaine abuse medicines, and valuable psychiatric drugs. In an attempt to elucidate effectual ...
The effects of plyometrics or resistance-training on markers of bone turnover and hormones in men
(University of Missouri--Columbia, 2009)
Weight-bearing exercise positively affects bone mineral density (BMD) and bone strength, presumably by altering the balance between bone formation and resorption. The purpose of the present study was to determine the acute ...
Using theory of reasoned action (TRA) in understanding selection and use of information resources : an information resource selection and use model
(University of Missouri--Columbia, 2008)
With advanced computer and networking technologies, more and more information can be accessed electronically. Information overload has become an issue and it is increasingly difficult for a user to quickly identify and ...
Development of an integrated approach combining artificial neural network material based on modeling with finite element analysis of forming processes
(University of Missouri--Columbia, 2005)
The use of a finite element model for design and analysis of a metal forming processes is limited by the incorporated material model's ability to predict deformation behavior over a wide range of operating conditions. ...
Ammonia elimination from protonated nucleobases
(University of Missouri--Columbia, 2007)
7 - 9, respectively. The stability of (E)- and (Z)-isomers is studied. The results are discussed of mass-spectrometric studies of the nucleobases adenine 1h (1, R = H), guanine 2h, and cytosine 3h. The protonated nucleobases are generated...
Identification of novel breast carcinoma and melanoma avid peptides for imaging
(University of Missouri--Columbia, 2009)
During the last decade, peptides and their derivatives have been employed as effective cancer imaging agents. We aimed to identify new peptides probes specific for melanoma and breast carcinoma by phage display technology. ...
Design of a signal scavenging sensor system for passive monitoring in elder care technology
(University of Missouri--Columbia, 2010)
This thesis describes sensors designed for a non-obtrusive monitoring system to detect and track the elderly adults walking on the carpet. The sensors are thin metal foils which detect environmental or scavenged energy. ...
Mechanisms of Alphavirus Midgut dissemination in the Mosquito, Aedes aegypti
(University of Missouri--Columbia, 2018)
The research work of this thesis has focused on the midgut escape barrier and the dissemination mechanism of alphaviruses in Ae. aegypti. Primarily, we identified and characterized Ae. aegypti MMPs that are seemingly ...
Processing of synthetic aperture radar data as applied to the characterization of localized deformation features
(University of Missouri--Columbia, 2009)
Satellite-based Interferometric Synthetic Aperture Radar (InSAR) has been used by the geoscience community for many years to obtain ground deformation measurements of large-scale spatial features. Researchers have also ...
Lipid mediators in the development and resolution of experimental lyme arthritis
(University of Missouri--Columbia, 2007)
The focus of my graduate studies was to determine the contribution of members of the eicosanoid cascade, namely the cyclooxygenase enzymes, to the regulation of experimental Lyme arthritis pathology. Using COX-2-specific ...
Micro-imaging characterization of mouse models of metastasis
(University of Missouri--Columbia, 2005)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Non-invasive imaging techniques have been recently developed to characterize animal models of disease. The overarching hypothesis of this work explores ...
Heritable, differential gene expression in pre-implantation embryos from rats with endometriosis and their daughters
(University of Missouri--Columbia, 2010)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Endometriosis, which affects millions of women, is a condition where the uterine lining grows outside of the uterus and is associated with subfertility ...
Maladaptation of cardiac and skeletal muscle in chronic disease : effects of exercise
(University of Missouri--Columbia, 2007)
The human genome is adapted for daily physical activity (85). Thus, a sedentary lifestyle is capable of promoting detrimental consequences to human health. The linkage between lack of sufficient physical activity and the ...
Flourescent molecular rotors as mechanosensors in biofluids
(University of Missouri--Columbia, 2005)
Many disease states have associated blood viscosity changes. Molecular rotors, fluorescent molecules with viscosity sensitive quantum yields, have recently been investigated as a new method for biofluid viscosity measurement. ...
Structural supramolecular constructs of spheres and tubes
(University of Missouri--Columbia, 2006)
This thesis examines four different molecular systems that are in part or substrates for larger structural motifs that resemble spheres or tubes. The first project used donut shaped cucurbituril and through functionalization ...
Long Term Ocular Drug Delivery with Novel Pentablock Copolymers; Part I: Composite Nanoformulation of Macromolecules For Back of the Eye Diseases, Part II: Dexamethasone Nanoparticle to Develop an In Vitro Model for Glaucoma
(University of Missouri -- Kansas City, 2017)
Pentablock (PB) copolymers have been successfully synthesized for long term delivery in
the treatment of posterior segment ocular diseases. PB copolymers are comprised of FDA
approved biodegradable polymer such as ...