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Synthesis and structure-activity relationship of a series of sigma receptor ligands
(University of Missouri--Columbia, 2007)
Sigma receptors are involved in several biological processes, and sigma ligands might be promising as cancer treatment agents, cocaine abuse medicines, and valuable psychiatric drugs. In an attempt to elucidate effectual ...
Ligands for the sigma receptor and the mu-opioid receptor
(University of Missouri--Columbia, 2007)
analogues were synthesized as sigma ligands. Sigma receptors binding assays were conducted for the piperidine analogues. The last chapter is concerned with the opioid receptors, which have three subtypes: mu, delta, and kappa. The [mu]-opioid receptor...