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The minimal primary structures of RNA aptamers selected to bind HIV-1 reverse transcriptase
(University of Missouri--Columbia, 2010)
Human Immunodeficiency Virus (HIV) reverse transcriptase (RT) is the most common molecular target of current HIV treatments. Oligonucleotide aptamers bind and inhibit the RNA- and DNA-dependent polymerization activities ...
Phage display peptides for breast cancer targeting
(University of Missouri--Columbia, 2010)
Cancer cell surfaces differ from healthy cell surfaces allowing the detection of cancer targets on the cell. Use of these targets combined with radiolabeled targeting vehicles results in sensitive imaging agents, with ...
Divalent ion-binding and thermal stability studies on rat [beta]-parvalbumin and the evidence of influential distant amino acid residues affecting CD site ion affinity
(University of Missouri--Columbia, 2011)
Parvalbumins (PVs) are vertebrate-specific proteins (Mr 12,000), which harbor two EF-hand motifs known as the CD and EF sites. Although the CD and EF sites are typically high-affinity sites, the mammalian [beta]-PV exhibits ...
Improvement of Biochemistry 2002 through experimental modification and organization of course materials
(University of Missouri--Columbia, 2011)
The University of Missouri Biochemistry department offers a variety of courses, each designed with a specific purpose and scheduled to avoid overlap. Biochemistry 2002, sophomore lab, is currently an elective course meant ...
Monosaccharide-binding of cystic fibrosis pseudomonas aeruginosa: glycopolymer preparations, methods development and phenotype assessment
(University of Missouri--Columbia, 2014)
Shape modeling framework for brain and facial image analysis
(University of Missouri--Columbia, 2011)
The field of medical image analysis has greatly influenced the practice of neuroscience. Many studies aim to find new disease related anatomical characteristics based on the analysis of Magnetic Resonance images (MRI). ...
Structure and conformational signaling in the escherichia coli aspartate receptor tar
(University of Missouri--Columbia, 2014)
Comparison of standard treatments of breast cancer with new experimental treatments targeting caveolin-1
(University of Missouri--Columbia, 2013)
Breast cancer is a complex disease at both an anatomical and molecular levels. The complexity of the disease is a source of difficulty in identifying and treating the cancer, since varying subtypes of cancer respond ...
Characterization of the 14-3-3 client protein interactome from developing arabidopsis seed and regulation by protein phosphorylation
(University of Missouri--Columbia, 2013)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Understanding the regulatory mechanisms controlling reserve deposition during seed development is an academic endeavor with the potential for socioeconomic ...
The role of Rex in regulation of sulfate reduction in Desulfovibrio vulgaris Hildenborough
(University of Missouri--Columbia, 2014)
Although the enzymes for dissimilatory sulfate reduction by microbes have been studied, the mechanism for transcriptional regulation of the encoding genes remain unknown. In the work presented here, the model sulfate-reducing ...
Development of novel breast cancer-targeted spect imaging peptides by phage display
(University of Missouri--Columbia, 2014)
Malignancy of the breast is the leading cause of cancer among women and the second leading cause of cancer-related death. Despite implementation of mammograms and breast exams, there still exists a need to detect highly ...
The tertiary structure of calcium-bound Phl 7, a polcalcin, from timothy grass
(University of Missouri--Columbia, 2012)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Polcalcins are small proteins found in the anthers and pollen of flowering plants. They are potent allergens and are surmised to be regulatory proteins ...
Pamp triggered responses as the first layer of immunity reprogramming cells for defense in both mammals and plants
(University of Missouri--Columbia, 2013)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Both mammals and plants live in a constant co-existence with a broad range of microbes. Some of these microbes have the potential to be pathogenic and ...
Neuroprotective roles of the P2Y[subscript 2] nucleotide receptor
(University of Missouri--Columbia, 2014)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Alzheimer's disease (AD) is the most prevalent neurodegenerative disease. AD is an important disease to study because of the high cost of care for ...
The role of the P2Y2 nucleotide receptor in salivary gland regeneration
(University of Missouri--Columbia, 2014)
Salivary gland dysfunction affects millions of Americans whose quality of life is severely impacted by dry mouth, oral bacterial infections, poor nutrition, and other disorders that are associated with decreased saliva ...
Biophysical studies of protein dynamics
(University of Missouri--Columbia, 2014)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The Ribosome is the compact nanomachine with multiple coordinated components working together to translate the genetic code in the mRNA into linear ...
Characterization of membrane-associated SecA
(University of Missouri--Columbia, 2014)
Mechanisms of salivary gland cell proliferation in vitro by P2Y2R activation
(University of Missouri--Columbia, 2012)
Sjögren's syndrome (SS) and the side-effects of γ-radiation therapies for head and neck cancers cause salivary gland dysfunction. Salivary gland regeneration has been considered to be a very promising approach for restoring ...
Bacteriophage display selections of ovarian cancer avid peptides
(University of Missouri--Columbia, 2014)
Elucidating the roles of the ATP7A copper transporter in cultured cells, tumor growth and metastasis
(University of Missouri--Columbia, 2013)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Copper is an essential trace metal in all organisms. In humans, copper plays structural and catalytic roles for numerous enzymes and is required for ...