Q: Do statins alter the risk or progression of dementia? Evidence-based answer: No. Moderate-intensity statin therapy (with pravastatin or simvastatin) doesn't prevent progression to dementia in patients at increased risk. ...

Q: How often does long-term PPI therapy cause clinically significant hypomagnesemia? EVIDENCE-BASED ANSWER: Rarely. Proton pump inhibitors (PPIs) may be associated with decreases in serum magnesium laboratory values to ...

Tamsulosin for patients with ureteral stones? Yes, but only for some. Find out which of your patients can benefit. PRACTICE CHANGER: Prescribe tamsulosin for stone expulsion in patients with distal ureteral stones 5 to 10 ...

Q: How well do POLST forms assure that patients get the end-of-life care they requested? A: quite well, for cardiopulmonary resuscitation (CPR). Most patients (91%-100%) who select "do not resuscitate" (DNR) on their ...

Q: What are the benefits and risks of daily low-dose aspirin for primary prevention of CV events? A: One nonfatal myocardial infarction (MI) will be avoided for every 126 to 138 adults who take daily aspirin for 10 years ...

Time to stop glucosamine and chondroitin for knee OA? Prior studies provided conflicting results regarding the efficacy of these medications. This study offers evidence for discontinuing them. Practice changer: Tell patients ...

Should you reassess your patient's asthma diagnosis? Asthma may not be a permanent diagnosis in adults. A study finds that up to one-third of adults with physician-diagnosed asthma no longer had it after 5 years. ...

Q: How effective and safe is fecal microbial transplant in preventing C difficile recurrence? Evidence-based answer: fecal microbial transplant (fmt) is reasonably safe and effective. In patients who have had multiple ...

Q: What's the best VTE treatment for patients with cancer? Evidence-based answer: No. Head-to-head studies directly compare all the main treatments for venous thromboembolism (VTE) in cancer patients. Long-term treatment ...

Time to switch to nonsterile gloves for these procedures? Are sterile gloves worth the extra cost for common cutaneous surgeries? This systematic review and meta-analysis provides answers. Practice changer: Using nonsterile ...

First-time, mild diverticulitis: antibiotics or watchful waiting? Dn't jump to antibiotic Tx for mild, uncomplicated diverticulitis, a recent RCT says. Observation may be just as effective. Practice changer: For mild, ...

"This essay examines some of the textual features of the Qur’ān that emerge more prominently when listening to it, features that may enhance insight gained during slow or silent reading sessions."--Page 141.

Does fish oil during pregnancy help prevent asthma in kids? The evidence on fish oil has been mixed, but this study affirms its benefits--in certain women. PRACTICE CHANGER: Fish oil supplementation taken by women in the ...

Q: How do oral NSAIDs compare to other oral analgesics right after an acute musculoskeletal injury? A: nonsteroidal anti-inflammatory drugs(NSAIDs) are at least as effective as other oral analgesics (opioids, acetaminophen) ...

"It is my argument that not only can the ritual texts of the Naxi people of southwest China be proven to be demonstrably oral in nature, but that they also exist in a realm of potentiality that occupies the uncontested ...

What's the best treatment setting for stable PE patients? The answer seems to be the outpatient setting. Here's why. PRACTICE CHANGER: Manage patients with acute pulmonary embolism (PE) who are hemodynamically stable in ...

Sepsis trajectories, including onset and recovery, can be difficult to assess, but electronic health records (EHRs) can accurately capture sepsis as a dynamic episode.

Q: Does niacin decrease cardiovascular morbidity and mortality in CVD patients? A: No. Niacin doesn't reduce cardio- vascular disease (CVD) morbidity or mortality in patients with established disease (strength of recommendation ...

"The fairy-seers are called numerous names in various languages across southeastern Europe. The semantic field of these varying designations is far from identical: sometimes the seers need not enter into a trance to see ...

"In lines 607-61 of Beowulf, just before the battle between the hero and the monster Grendel, the Danes and visiting Geats celebrate their comradeship in the great hall of Heorot. While venerable Hrothgar, king of the ...