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A novel PCR based DNA microanalyzer system for detection of viral genome
(University of Missouri--Columbia, 2006)
A micro-fluidic assay to quickly analyze microscopic samples of DNA is being developed for field applications. It consists of a micro-PCR chamber, micropumps, and micro-heaters. Additional components of the device include ...
Development of a FRET biosensor to detect the pathogen mycoplasma capricolum
(University of Missouri--Columbia, 2005)
Mycoplasmas are a species of bacteria that invade any type of cell and are adaptable to changing environments. We are developing an optical biosensor based on Fluorescence Resonance Energy Transfer (FRET) for detection of ...
Ion-selective electrodes for simultaneous real-time analysis for soil macronutrients
(University of Missouri--Columbia, 2006)
Automated sensing of soil macronutrients (i.e., N, P, and K) would allow more efficient mapping of soil nutrient variability for variable-rate nutrient management. This study reports on the development of a sensor array ...
Development of a human immunodeficiency virus (HIV-1) biosensor utilizing liquid core waveguides
(University of Missouri--Columbia, 2007)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Millions of individuals are diagnosed each year with Human Immunodeficiency Virus Type 1. Each day more individuals are receiving antiretroviral ...
Optical glucose nanobiosensor encapsulated in erythrocytes
(University of Missouri--Columbia, 2007)
An implantable glucose biosensor encapsulated in erythrocytes, Red Blood Cells (RBC), will become a method for continuously measuring blood glucose concentration in diabetics. In 2005, the American Diabetes Association ...
Photoacoustic detection of metastatic melanoma in the human circulatory system
(University of Missouri--Columbia, 2006)
Detection of disseminating tumor cells can function as an early warning system, alerting the metastatic spread or recurrence of the disease. Early detection of such cells can result in preventative treatment of the disease ...
Modeling the influence of climate and management practices on water quality in Goodwater Creek experimental watershed
(University of Missouri--Columbia, 2006)
The objective of this study was to determine relationships among weather, runoff, water quality, and best management practice (BMP) implementation in reducing atrazine losses in the 7,250-ha Goodwater Creek Experimental ...
Nano- and micro-scale studies of exocytosis
(University of Missouri--Columbia, 2007)
Neurons and neuroendocrine cells contain vesicles packed with hormones or neurotransmitters. Upon appropriate stimulation, a rise in intracellular Ca2+ concentration triggers the fusion of vesicles with the outer membrane ...
Investigative study of long-term packaging effects and donor characteristics on acellular dermis scaffolds
(University of Missouri--Columbia, 2008)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Acellular tissue sources have become progressively popular for a variety of tissue engineering and medical applications, such as soft tissue augmentation, ...
A fiber-optic confocal scanner for scattering tissue
(University of Missouri--Columbia, 2009)
Confocal microscopy has become an important diagnostic tool in examining scattering tissues. The high resolution of confocal microscopy and its optical sectioning capabilities lend itself as a desirable modality in examining ...
CPLA2: key enzyme for astroctytic cell membrane phase property change induced by abeta
(University of Missouri--Columbia, 2007)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The interaction of amyloid beta peptide (A[beta]) and cell membrane is believed to be the basis of its biological function including its toxicity to ...
Ratiometric techniques to determine fluid viscosity using molecular rotors
(University of Missouri--Columbia, 2007)
Molecular rotors exhibit viscosity-dependent quantum yield, potentially allowing measurements of fluid viscosity in non-mechanical manner. Several diseases are accompanied by blood plasma viscosity changes; therefore, a ...
Detection of CD4 and CD8 t-lymphocytes and HER2 breast cancer biomarker using the opto-fluidic ring resonator biosensor
(University of Missouri--Columbia, 2009)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] We have demonstrated label-free detection of CD4+ and CD8+ T-Lymphocytes and HER2 breast cancer biomarker using the opto-fluidic ring resonator (OFRR) ...
Optical characterization of skeletal muscles
(University of Missouri--Columbia, 2007)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The optical absorption and reduced scattering coefficients of bulk skeleton muscle were measured by fitting the diffusion model to spatially resolved ...
Logistic modeling of a biomass utilization system
(University of Missouri--Columbia, 2009)
A logistic model was developed for a biomass utilization system and implemented in ExtendSim. The model allows for system simulation and analysis of biomass supply chain in terms of economic viability and energy balance. ...
Visible reflectance spectroscopy to observe the effect of copper embedded socks on erythema in feet
(University of Missouri--Columbia, 2008)
Objective assessment of skin characteristics is necessary to aid in the clinical detection of erythema and debilitating skin conditions. The ability to treat different skin pathologies based on individual patient skin ...
Aptamer encoded nanopores as single molecule sensors
(University of Missouri--Columbia, 2008)
We have created a low noise, calibrated, molecular-scaled pore. The nanopore is formed either by micro-forge polishing or external penetration of the nanocavity sealed in the pipette terminal. The nanopore fabrication is ...
Development of electrospun synthetic bioabsorbable fibers for a novel bionanocomposite hernia repair material
(University of Missouri--Columbia, 2008)
In order to create a more durable and biocompatible hernia repair mesh, a novel bionanocomposite material based on the crosslinking of bioabsorbable polymer fibers to decellularized porcine diaphragm tissue is proposed. ...
Properties of extruded white corn flour - high amylose corn starch puffs
(University of Missouri--Columbia, 2008)
This study was conducted to determine the effect of high-amylose corn starch in corn puffs on the extrusion parameters, product and textural properties and the glass transition temperature. The data was analyzed in a ...
Gating of CFTR chloride channels : distinct closed states revealed by the action of AMP-PNP
(University of Missouri--Columbia, 2006)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The CFTR chloride channel is gated by ATP through an irreversible gating cycle driven by an input of free energy of ATP hydrolysis. The open state of ...