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Encapsulation of docetaxel in oily core polyester nanocapsule intended for breast cancer therapy
(2011-12-14)
Abstract
This study is designed to test the hypothesis that docetaxel [Doc] containing oily core nanocapsules [NCs] could be successfully prepared with a high percentage encapsulation efficiency [EE%] and high drug loading. ...
Association of 25-hydroxyvitamin D deficiency with NT-pro BNP levels in patients with acute myocardial infarction: a cross-sectional analysis
(2011-12-15)
Abstract
Background
Nutritional vitamin D deficiency is an emerging risk factor for acute myocardial infarction (AMI) and heart failure. The association of 25-hydroxyvitamin D levels with N-terminal pro B-type natriuretic ...
Suppression of nitric oxide induction and pro-inflammatory cytokines by novel proteasome inhibitors in various experimental models
(2011-10-12)
Abstract
Background
Inflammation has been implicated in a variety of diseases associated with ageing, including cancer, cardiovascular, and neurologic diseases. We have recently established that the proteasome ...
Inhibition of nitric oxide in LPS-stimulated macrophages of young and senescent mice by delta-tocotrienol and quercetin.
(2011-12-20)
Abstract
Background
Changes in immune function believed to contribute to a variety of age-related diseases have been associated with increased production of nitric oxide (NO). We have recently reported that ...
GAL1-SceI directed site-specific genomic (gsSSG) mutagenesis: a method for precisely targeting point mutations in S. cerevisiae.
(2011-12-05)
Abstract
Background
Precise targeted mutations are defined as targeted mutations that do not require the retention of other genetic changes, such as marker genes, near the mutation site. In the yeast, S. cerevisiae, ...
Comparative genome sequence analysis underscores mycoparasitism as the ancestral life style of Trichoderma
(2011-04-18)
Abstract
Background
Mycoparasitism, a lifestyle where one fungus is parasitic on another fungus, has special relevance when the prey is a plant pathogen, providing a strategy for biological control of pests for plant ...
Design, baseline characteristics, and retention of African American light smokers into a randomized trial involving biological data
(2011-01-25)
Abstract
Background
African Americans experience significant tobacco-related health disparities despite the fact that over half of African American smokers are light smokers (use ≤10 cigarettes per day). African ...
A Bayesian Analysis for Identifying DNA Copy Number Variations Using a Compound Poisson Process
(2010-08-17)
To study chromosomal aberrations that may lead to cancer formation or genetic diseases, the array-based Comparative Genomic Hybridization (aCGH) technique is often used for detecting DNA copy number variants (CNVs). Various ...
Silencing of the IKKepsilon gene by siRNA inhibits invasiveness and growth of breast cancer cells
(2010-09-23)
Abstract
Introduction
IκB kinase ε (IKKε) is a member of the IKK family that plays an important role in the activation of NF-κB. Overexpressed in more than 30% of breast cancers, IKKε has been ...
Investigation of 95 variants identified in a genome-wide study for association with mortality after acute coronary syndrome
(2011-09-29)
Abstract
Background
Genome-wide association studies (GWAS) have identified new candidate genes for the occurrence of acute coronary syndrome (ACS), but possible effects of such genes on survival following ACS ...
Gene selection for classification of microarray data based on the Bayes error
(2007-10-03)
Abstract
Background
With DNA microarray data, selecting a compact subset of discriminative genes from thousands of genes is a ...
TILLING to detect induced mutations in soybean
(2008-01-24)
Abstract
Background
Soybean (Glycine max L. Merr.) is an important nitrogen-fixing crop that provides much of the world's protein ...
Effect of stroke location on the laryngeal cough reflex and pneumonia risk
(2005-08-04)
Abstract
Background
The purpose of this study was to evaluate the risk of developing pneumonia in acute stroke patients comparing ...
Evaluation of the true precocious puberty rats induced by neonatal administration of Danazol: Therapeutic effects of nourishing "Yin"- removing "Fire" Chinese herb mixture
(2005-08-22)
Abstract
Background
Nourishing "Yin"-Removing "Fire" Chinese Herb Mixture, a traditional herb-based formulation, has been successfully ...
Assessing responsiveness of generic and specific health related quality of life measures in heart failure
(2006-11-24)
Abstract
Background
Responsiveness, or sensitivity to clinical change, is an important consideration in selection of a ...
The validity of self-rated health as a measure of health status among young military personnel: evidence from a cross-sectional survey
(2006-08-29)
Abstract
Background
Single item questions about self ratings of overall health status are widely used in both military and ...
Tandem repeat regions within the Burkholderia pseudomallei genome and their application for high resolution genotyping
(2007-03-30)
Abstract
Background
The facultative, intracellular bacterium Burkholderia pseudomallei is the causative agent of melioidosis, a ...
Associations between the built environment and physical activity in public housing residents
(2007-11-12)
Abstract
Background
Environmental factors may influence the particularly low rates of physical activity in African American and low-income adults. This cross-sectional study investigated ...
Hepatocarcinogenic potential of the glucocorticoid antagonist RU486 in B6C3F1 mice: effect on apoptosis, expression of oncogenes and the tumor suppressor gene p53
(2003-01-03)
Abstract
Background
Glucocorticoids inhibit hepatocellular proliferation and modulate the expression of oncogenes and tumor ...
FunnyBase: a systems level functional annotation of FundulusESTs for the analysis of gene expression
(2004-12-20)
Abstract
Background
While studies of non-model organisms are critical for many research areas, such as evolution, development, and ...