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Annual zoledronic acid infusion lowers risk of fracture, death
(Family Physicians Inquiries Network, 2007)
Patients with a prior hip fracture have 2.5 times the risk of a new fracture compared to age-matched persons without a previous hip fracture. For patients with a recent hip fracture, intravenous zoledronic acid annually ...
Vertebroplasty for osteoporotic fracture? Think twice
(Family Physicians Inquiries Network, 2009)
Think twice before recommending vertebroplasty (VP) for symptomatic osteoporotic compression fractures. New studies suggest that it has little benefit; thus, VP should be considered only after other, more conservative ...
Glucose control: How low should you go with the critically ill?
(Family Physicians Inquiries Network, 2009)
For hyperglycemic patients admitted to an intensive care unit (ICU), the target blood glucose level should be [less than or equal to] 180 mg/dL, not 81 to 108 mg/dL. More aggressive glucose lowering is associated with a ...
Ovary-sparing hysterectomy: Is it right for your patient?
(Family Physicians Inquiries Network, 2009)
Advise patients undergoing hysterectomy for benign conditions that there are benefits to conserving their ovaries. The risk of coronary heart disease (CHD) and death is lower in women whose ovaries are conserved, compared ...
Bisphosphonate therapy: When not to monitor BMD
(Family Physicians Inquiries Network, 2009)
After starting patients on bisphosphonates for osteoporosis, wait at least 3 years before ordering a repeat dual-energy x-ray absorptiometry (DXA) scan. Stength of recommendation: C: Based on a secondary analysis of a large ...
This antiemetic may help kids skip that trip to the hospital
(Family Physicians Inquiries Network, 2009)
Give oral ondansetron to children with acute gastroenteritis and moderate dehydration who are unable to tolerate oral rehydration to reduce the vomiting and avoid the need for intravenous (IV) hydration or hospitalization. ...
Ubiquitin C-terminal hydrolase-activity is involved in sperm acrosomal function and anti-polyspermy defense during porcine fertilization
(Society for the Study of Reproduction, 2007)
The 26S proteasome, which is a multi-subunit protease with specificity for substrate proteins that are postranslationally modified by ubiquitination, has been implicated in acrosomal function and sperm-zona pellucida (ZP) ...
Kinetics and mechanism of protein tyrosine phosphatase 1B inactivation by acrolein
(American Chemical Society, 2007)
Human cells are exposed to the electrophilic [alpha],[beta]-unsaturated aldehyde acrolein from a variety of sources. The reaction of acrolein with functionally critical protein thiol residues can yield important biological ...
Does furosemide decrease morbidity or mortality for patients with diastolic or systolic dysfunction?
(Family Physicians Inquiries Network, 2005)
No large-scale randomized, placebo-controlled trials evaluate furosemide's effect on mortality and long-term morbidity in diastolic or systolic dysfunction. In short-term studies, furosemide reduces edema, reduces ...
Can type 2 diabetes be prevented through diet and exercise?
(Family Physicians Inquiries Network, 2005)
Diets that result in long-term weight loss of 5% to 7%, along with moderate-intensity exercise for more than 150 minutes per week, reduce the incidence of type 2 diabetes for patients with impaired glucose tolerance (IGT) ...
Which medications can be split without compromising efficacy and safety?
(Family Physicians Inquiries Network, 2006)
Split tablets of lisinopril are as effective as whole tablets of the same dose for hypertension (SOR: B, based on small randomized crossover study). Similarly, split tablets of atorvastatin, lovastatin, and simvastatin are ...
What's the best treatment for sebaceous cysts?
(Family Physicians Inquiries Network, 2007)
Punch biopsy excision appears to be superior to traditional wide elliptical excision for the treatment of sebaceous cysts when intervention is necessary (strength of recommendation [SOR]: B, based on 1 small randomized ...
Which vaccinations are indicated after splenectomy?
(Family Physicians Inquiries Network, 2006)
Immunization against encapsulated bacterial pathogens decreases the incidence of post- splenectomy sepsis. Pneumococcal, meningococcal, and Haemophilus influenzae (Hib) vaccinations are indicated for patients after ...
A Storyteller's Story: Gladys A. Coggswell
(MU Museum of Art and Archaeology, 2005)
Mrs. Gladys A. Coggswell, a master traditional artist in African-American storytelling from Frankford, MO., will be the recipient of the 2005 Missouri Arts Award in the Individual Artist category. This prestigious award ...
Which drugs are most effective for moderate to severe depression in adolescents?
(Family Physicians Inquiries Network, 2008)
Fluoxetine is the only selective serotonin-reuptake inhibitor (SSRI) approved by the US Food and Drug Administration (FDA) to treat depression in children 8 years of age and older; it also has the most favorable benefit-to-risk ...
Which drugs are safest for moderate to severe depression in adolescents?
(Family Physicians Inquiries Network, 2008)
Selective serotonin-reuptake inhibitors (SSRIs) appear to be the safest, given current data. Major safety concerns--prompting a US Food and Drug administration (FDA) black box label warning--have been raised about increased ...
Which patients undergoing noncardiac surgery benefit from perioperative beta-blockers?
(Family Physicians Inquiries Network, 2008)
Patients with moderate to high cardiac risk (a Revised Cardiac Risk Index [RCRI] score of 2 or higher [Table]) have a reduced risk of in-hospital death following perioperative beta-blocker therapy (strength of recommendation ...
Which lab tests are best when you suspect hypothyroidism?
(Family Physicians Inquiries Network, 2008)
Thyroid-stimulating hormone (TSH) level is the preferred test for initial evaluation of suspected primary hypothyroidism (strength of recommendation [SOR]: C, expert opinion). If TSH is abnormal, a free thyroxine (T4) level ...
How should you manage an overweight breastfed infant?
(Family Physicians Inquiries Network, 2009)
Monitor the growth of exclusively breastfed babies by plotting routine weights and lengths on the World Health Organization (WHO) growth curve (strength of recommendation [SOR]: A, systematic reviews). Reassure parents ...
How best to manage the patient in term labor whose group B strep status is unknown?
(Family Physicians Inquiries Network, 2009)
Monitor the patient and treat her with intrapartum chemoprophylaxis based on identified risk factors, unless a rapid, highly sensitive (greater than or equal to 85%) polymerase chain reaction (PCR) test is immediately ...