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Transcriptome profiling of rattus norvegicus embryonic stem cells by RNA-sequencing
(University of Missouri--Columbia, 2014)
Embryonic Stem Cells (ESCs) are a critical tool for producing targeted knockout animals and understanding development. ESCs were successfully isolated from rats in 2008 and have been used in producing several targeted ...
Development of biological hip resurfacing in dogs
(University of Missouri--Columbia, 2012)
Total joint replacement remains an excellent treatment for patients with debilitating joint degeneration. However, joint replacement using non-absorbable prostheses can deteriorate and become loose over time. A superior ...
College of Veterinary Medicine commencement, 1999 May
(University of Missouri--Columbia. College of Veterinary Medicine., 1999)
"Commencement Ceremony, 1:00 PM, May 7, 1999, Jesse Auditorium, University of Missouri"
Investigation of novel therapeutic strategies for attenuating corneal fibrosis
(University of Missouri--Columbia, 2017)
growth factor beta (TGF[beta]). Non-surgical interventions allowing for the safe and complete clinical resolution of corneal fibrosis are currently lacking in physician and veterinary ophthalmology. In order to address this significant clinical need...
Vet Med Update, 2013 January
(University of Missouri--Columbia. College of Veterinary Medicine, 2013)
Vet Med Update, 2012 November
(University of Missouri--Columbia. College of Veterinary Medicine, 2012)
Vet Med Update, 2013 February
(University of Missouri--Columbia. College of Veterinary Medicine, 2013)
Molecular genetics of spinal muscular atrophy : insights into various routes of therapeutic intervention
(University of Missouri--Columbia, 2009)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Spinal Muscular Atrophy is an autosomal recessive neuromuscular disorder that is the leading genetic cause of infant mortality. In humans, a nearly ...
Effect of colostral administration practices on serum immunoglobulin concentration in dairy calves
(University of Missouri--Columbia, 2008)
Despite the accumulated understanding of the factors which affect passive transfer of colostral immunoglobulins and its recognized importance in dairy calves, approximately 35-40 % of US dairy calves have inadequate passive ...
Molecular genetic studies in canine inherited diseases including neonatal cerebellar ataxia, degenerative myelopathy and multiple system degeneration
(University of Missouri--Columbia, 2013)
provide powerful diagnostic DNA tests for dog breeders their veterinarians and but also provide spontaneously occurring canine models for human diseases. Since the first high quality dog genome reference sequence was published and made publically...
Development of model systems for the vector-host-pathogen interface of bubonic plague
(University of Missouri--Columbia, 2013)
Bubonic plague infections begin in the dermis when the pathogen is introduced by a flea during a routine blood feed. Several barriers separate Yersinia pestis from its replicative niche, including phagocytic cells in the ...
Complex microbiota targeted rederivation (CMTR) as an alternative method to study effect of gut microbiota on host physiology /
(University of Missouri--Columbia, 2016)
Rodent models are invaluable tools to study the effects of differing gut microbiota (GM) on health and disease. Our laboratory has demonstrated that mouse GM profiles vary among animal vendors suggesting that subtle ...
Yersinia pestis YopJ, YopT, and YopK coordinate programmed cell death and cytokine responses to promote pneumonic plague
(University of Missouri--Columbia, 2017)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Yersinia pestis has been responsible for three major pandemics of plague, including the infamous Black Death that killed 250 million people in Europe. ...
Discovering disease causing variants in dogs through whole genome sequencing
(University of Missouri--Columbia, 2017)
This dissertation focuses on the use of whole genome sequencing (WGS) for the identification of disease causing variants in canine genomes. A brief review on the historical milestones of genetics, the creation and ...
Dietary nutrients implicated in the etiopathogenesis of human and animal diseases
(University of Missouri--Columbia, 2017)
Hyperthyroidism is a spontaneous disease that results in an abnormal elevation of circulating concentrations of one or more thyroid hormones. Despite being the most commonly diagnosed endocrine disorder of domestic cats, ...
Discovery of novel hepatitis B virus (HBV) antivirals and analysis of mechanisms of action of HBV-targeting agents
(University of Missouri--Columbia, 2017)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Chronic hepatitis B virus (HBV) infection leads to liver disease, cirrhosis, and hepatocellular carcinoma. Globally, an estimated 50% of all hepatocellular ...
The feasibility of interspecific rescue of endothelial/hematopoietic lineage deficiency
(University of Missouri--Columbia, 2012)
Here we propose to develop a mouse model which will establish “proof of principle” for future development of large animal (e.g. pig) models which could be used as actual human solid organ and blood donors as well as in ...
Biodistribution of lead, arsenic, and gold nanoparticles following respiratory, oral and IV exposure of rats and swine
(University of Missouri--Columbia, 2008)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The presence of arsenic and lead in the environment above the naturally occurring levels can have detrimental health effects on people living in these ...