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Now showing items 181-200 of 2611
Menstrual disturbances in perimenopausal women: What's best?
(Family Physicians Inquiries Network, 2009)
It's best to start with nonsteroidal anti- inflammatory drugs (NSAIDs), which effectively reduce heavy menstrual bleeding (strength of recommendation [SOR]: B, systematic review of randomized clinical trials [RCTs]). ...
Are there any known health risks to early introduction of solids to an infant's diet?
(Family Physicians Inquiries Network, 2009)
Few studies support an association between early introduction of solid food and atopic conditions, obesity, or any other illness (strength of recommendation [SOR]: B, cohort studies with mixed results). Very weak evidence ...
Which strategies work best to prevent obesity in adults?
(Family Physicians Inquiries Network, 2009)
Regular physical activity decreases long-term weight gain (strength of recommendation [SOR]: B, 2 high-quality, randomized controlled trials [RCTs]). Decreasing fat intake (SOR: B, 1 high-quality systematic review) and ...
Treatment of Acute Sciatica
(Family Physicians Inquiries Network, 2007)
In patients with acute sciatica, bed rest and advice to stay active have similar outcomes on their functional status and perceived improvement. (Strength of Recommendation [SOR]: A) Spinal manipulation increases improvement ...
What's the best diagnostic evaluation of night sweats?
(Family Physicians Inquiries Network, 2007)
There is no single best evidence-based approach to the diagnostic evaluation of night sweats, given the limited number of studies on the subject. A detailed history, however, does appear to be the most important initial ...
What evaluation is best for an isolated, enlarged cervical lymph node?
(Family Physicians Inquiries Network, 2007)
The evaluation and follow-up of an isolated, enlarged cervical lymph node is determined by the presence of inflammation, duration, size, and associated symptoms. For patients with inflammatory symptoms (ie, fever, pain, ...
What are the best treatments for herpes labialis?
(Family Physicians Inquiries Network, 2007)
There are 3: valacyclovir, acyclovir, and topical penciclovir. Valacyclovir, 2g twice in 1 day taken during the prodromal stage of herpes labialis, reduces the episode duration and time to healing. Acyclovir, 400 mg, taken ...
Ubiquitin C-terminal hydrolase-activity is involved in sperm acrosomal function and anti-polyspermy defense during porcine fertilization
(Society for the Study of Reproduction, 2007)
The 26S proteasome, which is a multi-subunit protease with specificity for substrate proteins that are postranslationally modified by ubiquitination, has been implicated in acrosomal function and sperm-zona pellucida (ZP) ...
Kinetics and mechanism of protein tyrosine phosphatase 1B inactivation by acrolein
(American Chemical Society, 2007)
Human cells are exposed to the electrophilic [alpha],[beta]-unsaturated aldehyde acrolein from a variety of sources. The reaction of acrolein with functionally critical protein thiol residues can yield important biological ...
Development and assessment of scoring functions for protein identification using PMF data
(Wiley-VCH, 2007)
PMF is one of the major methods for protein identification using the MS technology. It is faster and cheaper than MS/MS. Although PMF does not differentiate trypsin-digested peptides of identical mass, which makes it less ...
Guest and ligand behavior in zinc-seamed pyrogallol[4]arene molecular capsules
(Wiley-VCH, 2007)
Not just an inside job: Encapsulated and confined in an octanuclear zinc-seamed pyrogallol[4]arene molecular capsule, a guest of choice can act as a reporter for electronic communication between the exterior and the interior ...
Does furosemide decrease morbidity or mortality for patients with diastolic or systolic dysfunction?
(Family Physicians Inquiries Network, 2005)
No large-scale randomized, placebo-controlled trials evaluate furosemide's effect on mortality and long-term morbidity in diastolic or systolic dysfunction. In short-term studies, furosemide reduces edema, reduces ...
Can type 2 diabetes be prevented through diet and exercise?
(Family Physicians Inquiries Network, 2005)
Diets that result in long-term weight loss of 5% to 7%, along with moderate-intensity exercise for more than 150 minutes per week, reduce the incidence of type 2 diabetes for patients with impaired glucose tolerance (IGT) ...
Does anticoagulation prevent thrombosis for persons with fractures distal to the hip?
(Family Physicians Inquiries Network, 2005)
Low-molecular-weight heparin (LMWH) prophylaxis significantly reduces the total incidence of deep venous thrombosis (DVT) for patients with lower-limb fractures managed with surgical fixation and cast immobilization (strength ...
Do beta-blockers worsen respiratory status for patients with COPD?
(Family Physicians Inquiries Network, 2005)
Patients with chronic obstructive pulmonary disease (COPD) who use cardioselective beta-blockers (beta1-blockers) do not experience a significant worsening of their short-term pulmonary status as measured by changes in ...
Can we prevent splenic rupture for patients with infectious mononucleosis?
(Family Physicians Inquiries Network, 2005)
All patients with infectious mononucleosis should be considered at risk for splenic rupture since clinical severity, laboratory results, and physical exam are not reliable predictors of rupture (strength of recommendation ...
Can patients with steatohepatitis take statins?
(Family Physicians Inquiries Network, 2006)
Patients with steatohepatitis who take HMG Co-A reductase inhibitors (statins) lower their elevated liver enzymes and show evidence of improvement in fatty liver on follow-up imaging (strength of recommendation [SOR]: C, ...
Do allergy shots help seasonal allergies more than antihistamines and nasal steroids?
(Family Physicians Inquiries Network, 2006)
Multiple randomized controlled trials (RCTs) demonstrate the effectiveness of both allergen immunotherapy and antihistamines, with or without nasal steroids, in the treatment of seasonal allergic rhinitis (strength of ...
Are oral agents effective for the treatment of verruca vulgaris?
(Family Physicians Inquiries Network, 2006)
Of the available oral therapies for common warts, none has sufficient evidence to recommend it as an effective therapy (strength of recommendation [SOR]: B). To date, no oral agent has been shown to be effective in a ...
Do glucosamine and chondroitin worsen blood sugar control in diabetes?
(Family Physicians Inquiries Network, 2006)
Despite theoretical risks based on animal models given high intravenous doses, glucosamine/chondroitin (1500 mg/1200 mg daily) does not adversely affect short-term glycemic control for patients whose diabetes is well-controlled, ...