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Effect of a single AGE modification on the structure and chaperone activity of human alphaB-Crystallin
(American Chemical Society, 2007)
During aging, human lens proteins undergo several post-translational modifications, one of which is glycation. This process leads to the formation of advanced glycation end products (AGEs) which accumulate with time possibly ...
System analysis of an Arabidopsis mutant altered in de novo fatty acid synthesis reveals diverse changes in seed composition and metabolism
(American Society of Plant Biologists, 2009)
Embryo-specific overexpression of biotin carboxyl carrier protein 2 (BCCP2) inhibited plastid acetyl-coenzyme A carboxylase (ACCase), resulting in altered oil, protein, and carbohydrate composition in mature Arabidopsis ...
When should a chest x-ray be used to evaluate acute-onset productive cough for adults?
(Family Physicians Inquiries Network, 2005)
Even though the most common reason to order
a chest x-ray in the evaluation of an acute-onset, productive cough is to rule out pneumonia, there is no strong evidence to help a physician decide when to order this chest ...
Which late-stage Alzheimer's patients should be referred for hospice care?
(Family Physicians Inquiries Network, 2005)
Medicare guidelines are used to determine eligibility for hospice care (strength of recommendation [SOR]: C, based on expert opinion), but they correlate with 6-month mortality no better than an experienced clinician's ...
When should you order a Lyme titer?
(Family Physicians Inquiries Network, 2005)
Lyme titers should be ordered for patients with signs or symptoms of disseminated Lyme disease, but who do not have the pathognomonic erythema migrans rash (strength of recommendation [SOR]: C, based on expert opinion). ...
Who should get hepatitis A vaccination?
(Family Physicians Inquiries Network, 2005)
The following groups are at increased risk of contracting or having severe outcomes from hepatitis A and should receive vaccination.Persons traveling to or working in countries that have high or intermediate rates of ...
When is neuroimaging warranted for headache?
(Family Physicians Inquiries Network, 2005)
Neuroimaging is warranted to evaluate headaches when patients present to an emergency department with signs or symptoms of an intracranial lesion. These signs or symptoms include abrupt onset of headache, focal neurological ...
Establishment of a protein reference map for soybean root hair cells
(American Society of Plant Biologists, 2008)
Root hairs are single tubular cells formed from the differentiation of epidermal cells on roots. They are involved in water and nutrient uptake and represent the infection site on leguminous roots by rhizobia, soil bacteria ...
Do OTC remedies relieve cough in acute URIs?
(Family Physicians Inquiries Network, 2009)
Dextromethorphan (DM) for adults and honey for children provide some relief. DM may modestly decrease cough in adults compared with placebo (strength of recommendation [SOR]: B, systematic review of inconsistent or limited ...
Do abnormal fetal kick counts predict intrauterine death in average-risk pregnancies?
(Family Physicians Inquiries Network, 2009)
Structured daily monitoring of fetal movement doesn't decrease the rate of all- cause antenatal death in average-risk pregnancies (strength of recommendation [SOR]: B, single good-quality, randomized controlled trial [RCT]). ...
Do hyaluronic acid injections relieve OA knee pain?
(Family Physicians Inquiries Network, 2009)
Hyaluronic acid (HA) injections relieve pain more than placebo. The effect is small but similar to results from oral nonsteroidal anti-inflammatory drugs (NSAIDs) or steroid injection (strength of recommendation ([SOR]: ...
Does routine amniotomy have a role in normal labor?
(Family Physicians Inquiries Network, 2009)
Routine amniotomy doesn't significantly reduce the duration of first-stage labor in either primiparous or multiparous women (strength of recommendation [SOR]: A, systematic review of several randomized, controlled trials ...
Is training patients in self-examination an effective way to screen for melanoma?
(Family Physicians Inquiries Network, 2008)
No studies demonstrate that training patients to examine their skin decreases mortality from melanoma in the general population. Nor is there any evidence to suggest that teaching patients to monitor their skin for suspicious ...
Does reducing smoking in the home protect children from the effects of second-hand smoke?
(Family Physicians Inquiries Network, 2009)
In families of asthmatic children, education to reduce exposure to secondhand smoke leads to fewer medical visits (strength of recommendation [SOR]: B, a single randomized, controlled trial). The effects of educating ...
Are overweight children more likely to be overweight adults?
(Family Physicians Inquiries Network, 2009)
Overweight at any age in childhood increases the risk for overweight in adulthood. The relative risk (RR) ranges from 1.9 to 10.1 and increases as children get older. Not all overweight children become overweight adults, ...
Millimeter Laser Ranging to the Moon: a comprehensive theoretical model for advanced data analysis
(arXiv, 2009)
Lunar Laser Ranging (LLR) measurements are crucial for advanced exploration of the evolutionary history of the lunar orbit, the laws of fundamental gravitational physics, selenophysics and geophysics as well as for future ...
Enhanced Resource Sharing Through Group Interlibrary Loan Best Practices: A Conceptual, Structural, and Procedural Approach
(Johns Hopkins University Press, 2003)
Members of the Greater Western Library Alliance Interlibrary Loan Committee have spent more than two years developing a Best Practices model for Interlibrary Borrowing and Lending for consortia and local operations. The ...
Annealing-Dependent Magnetic Depth Profile in Ga[1-x]Mn[x]As
(American Physical Society, 2004)
We have studied the depth-dependent magnetic and structural properties of as-grown and optimally annealed Ga[1-x]Mn[x]As films using polarized neutron reflectometry. In addition to increasing total magnetization, the ...
Post-Newtonian Reference Frames for Advanced Theory of the Lunar Motion and a New Generation of Lunar Laser Ranging
(arXiv, 2009)
We construct a set of post-Newtonian reference frames for a comprehensive study of the orbital dynamics and rotational motion of Moon and Earth by means of lunar laser ranging (LLR) with the precision of one millimeter. ...
Astrodynamical Space Test of Relativity using Optical Devices I (ASTROD I) - A class-M fundamental physics mission proposal for Cosmic Vision 2015-2025
(arXiv, 2008)
ASTROD I is a planned interplanetary space mission with multiple goals. The primary aims are: to test General Relativity with an improvement in sensitivity of over 3 orders of magnitude, improving our understanding of ...