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Now showing items 221-240 of 290
Does risk tolerance change in response to market changes?
(2010)
Abstract only. Abstract: This study used the 1992-2006 waves of the Health and Retirement Study to investigate changes in risk tolerance levels over time in response to stock market returns. Findings indicate that risk ...
An Electro-magnetic cell stimulator [abstract]
(2010-03)
A device to stimulate bone and muscle cell growth and possibly for treatment of bone and muscle injuries is presented. The device, called EStim, generates electric and magnetic pulses at programmable intervals. This device ...
Comparative oncology and clinical translation of glyco protein conjugated gold nano therapeutic agent (GA-198AuNP) [abstract]
(2010)
As part of our efforts toward clinical translation of GA-198AuNP, our studies are focused on therapeutic efficacy of nanoparticulate GA198AuNP agent in dogs with prostatic carcinoma. The overall goal is to gain clinical ...
Use of Aggregation Prediction in Protein Formulations for Excipient Design
(2010-03)
A major concern in the development therapeutic protein formulations is protein aggregation. Proteins can interact to form bound groups of protein molecules or aggregates. Aggregates in protein formulations reduce effectiveness ...
Selective Laser Sintering and Freeze Extrusion Fabrication of Bioglass Bone Scaffolds [abstract]
(2010)
Bioactive glasses are promising materials for bone scaffolds due to their ability to assist in tissue regeneration. When implanted in vivo, bioactive glasses can convert to hydroxyapatite, the main mineral constituent of ...
INFORMER: A System for Immediate and Direct Notification of Critical Data for Patient Care [abstract]
(2010)
Efficient and timely delivery of healthcare requires constant improvements in the quality while keeping the cost of delivery under control. One of the important requirements for such delivery system is the timely notification ...
Development of Absorption and Fluorescence Probes Based on Mouse Model for Molecular Optical Imaging [abstract]
(2010)
In this work we summarize our collaborative research on a project to develop absorption and fluorescence targeting probes. Several groups from University of Missouri and Harry S. Truman Memorial Veteran's Hospital including ...
Leveraging Particle Size and Structure to Control Release of Pharmaceuticals for Human and Animal Health [abstract]
(2010)
Orbis Biosciences advances human and animal health pharmaceuticals and vaccines by leveraging controlled release platform technologies. Using Precision Particle Fabrication (PPF) technology, Orbis provides desired delivery ...
Pancreatic islet transplantation to treat diabetes - defining molecular tools to select suitable islets [abstract]
(2010)
A complete understanding of pancreatic islet biology is essential to the development of preventive or curative interventions for diabetes. It has been known that subpopulations of islets of different sizes exist; however, ...
High Resolution Crystal Structure of KD-247, a Humanized Antibody that Inhibits HIV Entry [abstract]
(2010-02)
Highly active antiretroviral therapy (HAART) has been very efficient in reducing the rate of mortality of human immunodeficiency virus type 1 (HIV-1) infected patients. However, resistance to clinically used drugs inevitably ...
Slipped deadlines and sample size shortfalls in clinical trials: a proposed remedy using a Bayesian model with an informative prior distribution [abstract]
(2010-03)
Background: The most common reason why clinical trials fail is that they fall well below their goals for patient accrual. Researchers will frequently overpromise and underdeliver on the number of patients that they can ...
Inhibition Mechanism of EFdA, a Highly Potent Inhibitor of HIV Reverse Transcriptase [abstract]
(2010-02)
The nucleoside 4'-ethynyl-2-fluoro-deoxyadenosine (EFdA) is one of the most
potent antiretroviral nucleosides yet described, inhibiting replication of wild-type and multidrug-resistant HIV-1 strains in vitro (PBMC cells) ...
Acid-sensing ion channels as a novel target for drug addiction [abstract]
(2010-03)
Improving the treatment and prevention of drug addiction is an important goal for modern medicine. Ion channels have recently become very attractive targets in the search of new pharmacotherapies. Extracellular proton ...
Novel inhibitors of Foot and Mouth Disease Virus (FMDV) Targeting the RNA-Dependent RNA Polymerase activity of 3Dpol [abstract]
(2010-03)
Foot-and-Mouth Disease Virus (FMDV) is a positive stranded picornavirus which infects cloven-hoofed animals, such as cattle, pigs and sheep, and leads to severe losses in livestock production. In the case of an FMD outbreak, ...
Brain Science and Living Neuronal Networks for Smart Grids [abstract]
(2010)
The objective of this multi-disciplinary collaborative research is to infuse more neurobiology into control systems, to make them more brain-like and better able to carry out real-time control of complex systems. This ...
Discovery and Mechanistic Characterization of Novel SARS Coronavirus Inhibitors that Block Viral Entry [abstract]
(2010-03)
Severe acute respiratory syndrome (SARS) is an infectious and highly contagious disease that is caused by SARS-associated coronavirus (SARS-CoV). Viral entry is a key target step for therapies because it can prevent the ...
Improving crop nitrogen response and production [abstract]
(2010-10)
Nitrogen is the most limiting nutrient for crop growth and production. Also, increasing amounts of nitrogen fertilizers are being applied in the field, a practice that causes major environmental damage and increases costs ...
A nanotechnology-based electrochemical DNA sensing apparatus and method [abstract]
(2010-10)
DNA is a code that contains the building instructions for all organisms and is the ultimate identification card. For example, the DNA code of a particular bacterium can tell if that particular strain of the bacterium is ...
Novel compounds to treat urinary tract infection [abstract]
(2010-10)
Urinary tract infections (UTI) affect a large proportion of the population and account for significant morbidity and high medical costs. Uropathogenic Escherichia coli (UPEC) is responsible for up to 85% of infections and ...
New inhibitor suppresses foot-and-mouth disease (FMD) [abstract]
(2010-10)
Foot-and-mouth Disease Virus (FMDV) is a positive stranded picornavirus that can infect cloven-hoofed animals, such as cattle, pigs and sheep, and lead to severe losses in livestock production. The delay in eradication or ...