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Azelnidipine attenuates inflammatory responses, siperoxide and relevant signaling pathways induced by amyloid-beta in mouse cerebral endothelial cells
(University of Missouri--Columbia, 2014)
Alzheimer's disease (AD) is a debilitating neurodegenerative disease with no known cure. The cause and progression of AD is still unclear. Over the years, studies have shown that one of the earliest cytotoxic effects is ...
The role of metabotropic glutamate receptor 5 in cerebral ischemia
(University of Missouri--Columbia, 2014)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Group I metabotropic glutamate receptor 5 (mGluR5), belongs to G-protein coupled receptors family and plays important roles in CNS disorders including ...
Plasmonic-enhanced fluorescent conjugated polymer chemosensor for ultra-sensitive detection of nitroaromatic vapors
(University of Missouri--Columbia, 2014)
Rapid degradation of fluorescent conjugated polymers in ambient conditions imposes severe restrictions on their utility for long-term, portable sensing applications. This dissertation discusses the combined use of low-density, ...
Detection of cold flow properties of diesel and biodiesel fuel using optical sensor
(University of Missouri--Columbia, 2006)
Identification of cloud point for biodiesel fuel can be used to optimize the performance of biodiesel fueled vehicles in cold weather. Cloud point is the temperature at which the smallest cluster of wax crystal is observed ...
Nano- and micro-scale studies of exocytosis
(University of Missouri--Columbia, 2007)
Neurons and neuroendocrine cells contain vesicles packed with hormones or neurotransmitters. Upon appropriate stimulation, a rise in intracellular Ca2+ concentration triggers the fusion of vesicles with the outer membrane ...
Ion-selective electrodes for simultaneous real-time analysis for soil macronutrients
(University of Missouri--Columbia, 2006)
Automated sensing of soil macronutrients (i.e., N, P, and K) would allow more efficient mapping of soil nutrient variability for variable-rate nutrient management. This study reports on the development of a sensor array ...
Optical glucose nanobiosensor encapsulated in erythrocytes
(University of Missouri--Columbia, 2007)
An implantable glucose biosensor encapsulated in erythrocytes, Red Blood Cells (RBC), will become a method for continuously measuring blood glucose concentration in diabetics. In 2005, the American Diabetes Association ...
Development of a capillary based helicobacter hepaticus biosensor
(University of Missouri--Columbia, 2006)
Helicobacter hepaticus causes hepatitis in mice. Infections with H. hepaticus can invalidate animal research studies and early detection helps curtail the spread of infection. The objective of this study was to develop a ...
Single-molecule investigation and nanopore-integrated biochip
(University of Missouri--Columbia, 2008)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Chlorella-encoded membrane protein Kcv was synthesized and purified in vitro. By co-synthesis and assembly of wild type with tagged version of Kcv, ...
The role of sodium-calcium exchanger in the electrical activity of embryonic chicken heart
(University of Missouri--Columbia, 2008)
Heart is one of the most important organs of the body and also it is one of the first organs during to the development. The electrical activity of heart is essential for its function. It has been shown that the sodium-calcium ...
Fibrous soy protein meat analog from low moisture twin-screw extrusion
(University of Missouri--Columbia, 2007)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Mixtures of soy protein isolate (SPI), defatted soy flour, and wheat flour were extruded at 34% (w.b.) moisture using a twin-screw extruder. A 3x3x3 ...
Synthesis and application of semiconductor quantum dots in novel sensing applications
(University of Missouri--Columbia, 2008)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] This thesis details the synthesis of CdSe/ZnS semiconductor nanocrystals (quantum dots). These quantum dots (QDs) show very interesting optical properties ...
Polyurethane foams from novel soy-based polyols
(University of Missouri--Columbia, 2008)
Polyurethane foams and molded plastic films were prepared by reacting isocyanates with polyols containing 50% of vegetable oil-based polyols and 50% of petroleum-based polyols. The vegetable oil-based polyols included ...
Optical reflectance in fibrous tissues and skeletal muscles
(University of Missouri--Columbia, 2008)
We studied diffuse optical reflectance in two anisotropic biological tissues: high moisture soy extrudates and skeletal muscles. High moisture extrusion of soy proteins can produce healthy alternative protein sources that ...
Effects of oxidative stress and Alzheimer's amyloid-beta peptide on astrocytes
(University of Missouri--Columbia, 2006)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Oxidative stress and deposition of amyloid-[beta] peptide (A[beta]) in brains have been hypothesized as causes of Alzheimer's disease (AD), and research ...
Flourescent molecular rotors as mechanosensors in biofluids
(University of Missouri--Columbia, 2005)
Many disease states have associated blood viscosity changes. Molecular rotors, fluorescent molecules with viscosity sensitive quantum yields, have recently been investigated as a new method for biofluid viscosity measurement. ...
Ratiometric techniques to determine fluid viscosity using molecular rotors
(University of Missouri--Columbia, 2007)
Molecular rotors exhibit viscosity-dependent quantum yield, potentially allowing measurements of fluid viscosity in non-mechanical manner. Several diseases are accompanied by blood plasma viscosity changes; therefore, a ...
CCVJ's fluorescence lifetime as a viscosity measurement tool and its possible application as a tunable picoseconds reference lifetime standard
(University of Missouri--Columbia, 2007)
9-(2-carboxy-2-cyanovinyl) julolidine (CCVJ, a molecular rotor) was shown to perform as a viscosity sensitive probe. Using steady state spectroscopy, CCVJ was shown to have decreased emission intensity as the environmental ...
Development of high-resolution optical tomography with a larger-size projection acquisition
(University of Missouri--Columbia, 2007)
In the industrial countries, the mortality from arteriosclerosis and cardiovascular diseases has been decreased, but they remain the most common circulatory disease. Recently, new tissue engineering technologies such as ...
Characterization of membrane viscosity changes with the novel molecular rotor FCVJ
(University of Missouri--Columbia, 2007)
Membrane viscosity can be defined as the "thickness" of a cell membrane. Membrane viscosity conditions are a useful indicator of cell health. Many diseases have been reported to induce changes in afflicted cell membrane ...