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Now showing items 21-40 of 66
Structural interactions sites of matrix metalloproteinase-12 with collagen triple helix, micelles, and a natural product from green tea
(University of Missouri--Columbia, 2012)
Matrix metalloproteinase (MMP-12) is associated with many costly, life-threatening diseases, such as atherosclerosis, pulmonary emphysema, asthma, and multiple sclerosis. Therefore, macrophage secreted MMP-12 is likely ...
The tertiary structure of calcium-bound Phl 7, a polcalcin, from timothy grass
(University of Missouri--Columbia, 2012)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Polcalcins are small proteins found in the anthers and pollen of flowering plants. They are potent allergens and are surmised to be regulatory proteins ...
Mechanisms of salivary gland cell proliferation in vitro by P2Y2R activation
(University of Missouri--Columbia, 2012)
Sjögren's syndrome (SS) and the side-effects of γ-radiation therapies for head and neck cancers cause salivary gland dysfunction. Salivary gland regeneration has been considered to be a very promising approach for restoring ...
The role of the P2Y2 nucleotide receptor in salivary gland regeneration
(University of Missouri--Columbia, 2014)
Salivary gland dysfunction affects millions of Americans whose quality of life is severely impacted by dry mouth, oral bacterial infections, poor nutrition, and other disorders that are associated with decreased saliva ...
Bacteriophage display selections of ovarian cancer avid peptides
(University of Missouri--Columbia, 2014)
Development of novel breast cancer-targeted spect imaging peptides by phage display
(University of Missouri--Columbia, 2014)
Malignancy of the breast is the leading cause of cancer among women and the second leading cause of cancer-related death. Despite implementation of mammograms and breast exams, there still exists a need to detect highly ...
Characterization of membrane-associated SecA
(University of Missouri--Columbia, 2014)
Biophysical studies of protein dynamics
(University of Missouri--Columbia, 2014)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The Ribosome is the compact nanomachine with multiple coordinated components working together to translate the genetic code in the mRNA into linear ...
Characterizing the retroviral envelope glycoprotein membrane proximal external region and membrane-spanning domains for their roles in helical alignment, fusogenicity, and incorporation into viral particles.
(University of Missouri--Columbia, 2015)
Viruses use surface proteins to gain access into target cells to initiate infection. How these surface proteins make it into assembling viral particles and the exact details of the entry process are poorly understood. My ...
Characterization of Esrrb function in metastatic prostate cancer cells and transcriptional regulation of hedgehog-signaling pathway target genes
(University of Missouri--Columbia, 2014)
Orphan nuclear receptor Estrogen Receptor Related Receptor Beta (Esrrb) is a transcription factor. Although it was also shown to be important in cancer, little is known about its function in cancer cells and cancer relevant ...
Nitrate and nitrite growth inhibition of Desulfovibrio strains
(University of Missouri--Columbia, 2014)
Sulfate-reducing bacteria, common non-pathogenic soil bacteria, have the ability to limit the movement of toxic heavy metals from one environmental site to another by keeping those metals from dissolving in water. Limiting ...
The role of Rex in regulation of sulfate reduction in Desulfovibrio vulgaris Hildenborough
(University of Missouri--Columbia, 2014)
Although the enzymes for dissimilatory sulfate reduction by microbes have been studied, the mechanism for transcriptional regulation of the encoding genes remain unknown. In the work presented here, the model sulfate-reducing ...
[alpha]A-crystallin derived peptide, [alpha]A66-80 induced aggregation and precipitation of soluble [alpha]-crystallin : a contribution to age-related cataract formation
(University of Missouri--Columbia, 2013)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Age-related cataract is the result of aggregation of lens proteins, crystallins. The formation of aggregates in the aging lens has been shown to correlate ...
The copper ATPases : intracellular trafficking and nervous system function
(University of Missouri--Columbia, 2013)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Copper is essential for life, as it participates as a cofactor in numerous enzymatic reactions including energy generation, antioxidant defense, ...
Pamp triggered responses as the first layer of immunity reprogramming cells for defense in both mammals and plants
(University of Missouri--Columbia, 2013)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Both mammals and plants live in a constant co-existence with a broad range of microbes. Some of these microbes have the potential to be pathogenic and ...
The influence of mRNA secondary structures on ribosome conformational dynamics
(University of Missouri--Columbia, 2016)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Synthesizing proteins in the cell is a critical aspect of life. Protein synthesis is a complicated process and involve highly functional machines at a ...
Structural studies of inhibition and resistance mechanism of EFDA, a human immunodeficiency virus reverse transcriptase inhibitor
(University of Missouri--Columbia, 2016)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.]
Protein components of the microbial mercury methylation pathway
(University of Missouri--Columbia, 2015)
Mercury (Hg) in the environment and the resulting methylmercury (CH3Hg+) produced by microorganisms has emerged as a global concern in the last 50 years after a series of high profile, large scale contamination events, ...
Stability, states, and interactions of the enzyme PMM/PGM by NMR and multivariate analysis
(University of Missouri--Columbia, 2016)
Phosphomannomutase/phosphoglucomutase (PMM/PGM) contributes to the infectivity of an opportunistic human pathogen Pseudomonas aeruginosa by participating in carbohydrate biosynthesis. As a phospho-transfer enzyme, PMM/PGM ...
Study of PVCA and PVCB, two enzymes involved in making isonitrile-containing natural products in bacterial pathogens
(University of Missouri--Columbia, 2016)
Isonitriles, with an unusual functionality, are very versatile intermediates widely involved in organic synthesis. Interestingly, a variety of isonitriles were encountered in both marine and terrestrial systems as the ...