Search
Now showing items 21-40 of 146
Kidney and cystic volume imaging for disease presentation and progression in the cat autosomal dominant polycystic kidney disease large animal model
(BioMed Central Ltd., 2019)
Background: Approximately 30 percent of Persian cats have a c.10063C > A variant in polycystin 1 (PKD1) homolog causing autosomal dominant polycystic kidney disease (ADPKD). The variant is lethal in utero when in the ...
Mechanical dilation, botulinum toxin A injection, and surgical myotomy with fundoplication for treatment of lower esophageal sphincter achalasia-like syndrome in dogs
(Blackwell Publishing Inc., 2019)
Background: Megaesophagus (ME) carries a poor long-term prognosis in dogs. In people, lower esophageal sphincter (LES) achalasia is a rare cause of ME that may respond to targeted intervention. Dogs with lower esophageal ...
Maximizing expected coverage of flow and opportunity for diversion in networked systems
(Springer New York LLC, 2019)
Placement of facilities, such as those providing surveillance or assistance functions, is essential for effective and efficient system operation. Planning for where to provide these types of services in a network necessitates ...
Shift from primary pneumonic to secondary septicemic plague by decreasing the volume of intranasal challenge with Yersinia pestis in the murine model
(Public Library of Science, 2019)
Yersinia pestis is the causative agent of pneumonic plague, a disease involving uncontrolled bacterial growth and host immunopathology. Secondary septicemic plague commonly occurs as a consequence of the host inflammatory ...
Investigating short-term and long-term binder performance of high-RAP mixtures containing waste cooking oil
(Periodical Offices of Chang- an University, 2019)
The environmental and economic benefits of recycling asphalt pavements have received much attention in recent years. Because of the increase in the cost of raw materials and energy carriers, the reuse of large portions of ...
Mocha tyrosinase variant : a new flavour of cat coat coloration
(Blackwell Publishing Ltd, 2019)
A novel coloration named ‘mocha' has been identified in the Burmese cat breed from Thailand. Tyrosinase (TYR) mutations are known to be associated with coat coloration in cats, such as the sable Burmese, the points of the ...
Improvement of in vitro and early in utero porcine clone development after somatic donor cells are cultured under hypoxia
(John Wiley and Sons Inc., 2019)
Genetically engineered pigs serve as excellent biomedical and agricultural models. To date, the most reliable way to generate genetically engineered pigs is via somatic cell nuclear transfer (SCNT), however, the efficiency ...
Structure of the gene therapy vector, adeno-associated virus with its cell receptor, AAVR
(eLife Sciences Publications Ltd, 2019)
Adeno-associated virus (AAV) vectors are preeminent in emerging clinical gene therapies. Generalizing beyond the most tractable genetic diseases will require modulation of cell specificity and immune neutralization. ...
Structural and dynamical description of the enzymatic reaction of a phosphohexomutase
(American Crystallographic Association, 2019)
Enzymes are known to adopt various conformations at different points along their catalytic cycles. Here, we present a comprehensive analysis of 15 isomorphous, high resolution crystal structures of the enzyme phosphoglucomutase ...
Synthesis, Derivatization, and Structural Analysis of Phosphorylated Mono-, Di-, and Trifluorinated d -Gluco-heptuloses by Glucokinase: Tunable Phosphoglucomutase Inhibition
(American Chemical Society, 2019)
Glucokinase phosphorylated a series of C-1 fluorinated [alpha]-d-gluco-heptuloses. These phosphorylated products were discovered to be inhibitors of [alpha]-phosphomannomutase/phosphoglucomutase ([alpha]PMM/PGM) and ...
Autocryopicker : an unsupervised learning approach for fully automated single particle picking in Cryo-EM images
(BioMed Central Ltd., 2019)
Background: An important task of macromolecular structure determination by cryo-electron microscopy (cryo-EM) is the identification of single particles in micrographs (particle picking). Due to the necessity of human ...
A microfluidic based biosensor for rapid detection of Salmonella in food products
(Public Library of Science, 2019)
An impedance based microfluidic biosensor for simultaneous and rapid detection of Salmonella serotypes B and D in ready-to-eat (RTE) Turkey matrix has been presented. Detection of Salmonella at a concentration as low as ...
Isolation and characterization T4-and T7-like phages that infect the bacterial plant pathogen agrobacterium tumefaciens
(MDPI AG, 2019)
In the rhizosphere, bacteria–phage interactions are likely to have important impacts on the ecology of microbial communities and microbe–plant interactions. To better understand the dynamics of Agrobacteria–phage interactions, ...
Accelerated fill-up of the Arbuckle Group aquifer and links to U.S. midcontinent seismicity
(Blackwell Publishing Ltd, 2019)
The Arbuckle Group aquifer is the principal disposal zone for oil and gas field brines and hazardous/nonhazardous wastewater across the U.S. midcontinent and is traditionally viewed as an infinite capacity aquifer. Thousands ...
Rats selectively bred for high voluntary physical activity behavior are not protected from the deleterious metabolic effects of a Western diet when sedentary
(Oxford University Press, 2019)
Background: Physical activity and diet are well-established modifiable factors that influence chronic disease risk. We developed a selectively bred, polygenic model for high and low voluntary running (HVR and LVR, respectively) ...
Yersinia pestis exploits early activation of MyD88 for growth in the lungs during pneumonic plague
(American Society for Microbiology, 2019)
Yersinia pestis causes bubonic, pneumonic, and septicemic plague. Although no longer responsible for pandemic outbreaks, pneumonic plague continues to be a challenge for medical treatment and has been classified as a ...
Something old and something new : future directions in vocational research with people of color in the United States
(SAGE Publications Inc., 2019)
Vocational psychology scholarship has largely overlooked the work experiences of people of color. In this article, we present evidence that vocational research that addresses the work issues of people of color has been ...
Concurrent and long-term associations between the endometrial microbiota and endometrial transcriptome in postpartum dairy cows
(BioMed Central Ltd., 2019)
Background: Fertility in dairy cows depends on ovarian cyclicity and on uterine involution. Ovarian cyclicity and uterine involution are delayed when there is uterine dysbiosis (overgrowth of pathogenic bacteria). Fertility ...
Direct visualization of the E. coli Sec translocase engaging precursor proteins in lipid bilayers
(American Association for the Advancement of Science, 2019)
Escherichia coli exports proteins via a translocase comprising SecA and the translocon, SecYEG. Structural changes of active translocases underlie general secretory system function, yet directly visualizing dynamics has ...
Comparative proteomic analysis unveils critical pathways underlying the role of Nitrogen fertilizer treatment in American elderberry
(MDPI AG, 2019)
American elderberry (Sambucus nigra subsp. canadensis) is a rapidly growing specialty crop in Missouri and eastern North America. Nitrogen (N) is a major nutrient involved in plant growth and development. However, proteome ...