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Now showing items 21-40 of 97
The role of Rex in regulation of sulfate reduction in Desulfovibrio vulgaris Hildenborough
(University of Missouri--Columbia, 2014)
Although the enzymes for dissimilatory sulfate reduction by microbes have been studied, the mechanism for transcriptional regulation of the encoding genes remain unknown. In the work presented here, the model sulfate-reducing ...
Development of novel breast cancer-targeted spect imaging peptides by phage display
(University of Missouri--Columbia, 2014)
Malignancy of the breast is the leading cause of cancer among women and the second leading cause of cancer-related death. Despite implementation of mammograms and breast exams, there still exists a need to detect highly ...
The tertiary structure of calcium-bound Phl 7, a polcalcin, from timothy grass
(University of Missouri--Columbia, 2012)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Polcalcins are small proteins found in the anthers and pollen of flowering plants. They are potent allergens and are surmised to be regulatory proteins ...
Pamp triggered responses as the first layer of immunity reprogramming cells for defense in both mammals and plants
(University of Missouri--Columbia, 2013)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Both mammals and plants live in a constant co-existence with a broad range of microbes. Some of these microbes have the potential to be pathogenic and ...
Neuroprotective roles of the P2Y[subscript 2] nucleotide receptor
(University of Missouri--Columbia, 2014)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Alzheimer's disease (AD) is the most prevalent neurodegenerative disease. AD is an important disease to study because of the high cost of care for ...
The role of the P2Y2 nucleotide receptor in salivary gland regeneration
(University of Missouri--Columbia, 2014)
Salivary gland dysfunction affects millions of Americans whose quality of life is severely impacted by dry mouth, oral bacterial infections, poor nutrition, and other disorders that are associated with decreased saliva ...
Biophysical studies of protein dynamics
(University of Missouri--Columbia, 2014)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The Ribosome is the compact nanomachine with multiple coordinated components working together to translate the genetic code in the mRNA into linear ...
Characterization of membrane-associated SecA
(University of Missouri--Columbia, 2014)
Mechanisms of salivary gland cell proliferation in vitro by P2Y2R activation
(University of Missouri--Columbia, 2012)
Sjögren's syndrome (SS) and the side-effects of γ-radiation therapies for head and neck cancers cause salivary gland dysfunction. Salivary gland regeneration has been considered to be a very promising approach for restoring ...
Bacteriophage display selections of ovarian cancer avid peptides
(University of Missouri--Columbia, 2014)
Elucidating the roles of the ATP7A copper transporter in cultured cells, tumor growth and metastasis
(University of Missouri--Columbia, 2013)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Copper is an essential trace metal in all organisms. In humans, copper plays structural and catalytic roles for numerous enzymes and is required for ...
Plant protein lysine acetylation
(University of Missouri--Columbia, 2013)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Amongst the hundreds of known protein posttranslational modifications, lysine acetylation is noteworthy for its widespread distribution, and for having ...
Characterization of PGAM5
(University of Missouri--Columbia, 2013)
Programmed cell death (PCD) is a naturally occurring event that is highly regulated and required for normal development. The protein phosphoglycerate mutase 5 (PGAM5) has been implicated in apoptosis, necrosis, and autophagy ...
[alpha]A-crystallin derived peptide, [alpha]A66-80 induced aggregation and precipitation of soluble [alpha]-crystallin : a contribution to age-related cataract formation
(University of Missouri--Columbia, 2013)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Age-related cataract is the result of aggregation of lens proteins, crystallins. The formation of aggregates in the aging lens has been shown to correlate ...
The copper ATPases : intracellular trafficking and nervous system function
(University of Missouri--Columbia, 2013)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Copper is essential for life, as it participates as a cofactor in numerous enzymatic reactions including energy generation, antioxidant defense, ...
Structural interactions sites of matrix metalloproteinase-12 with collagen triple helix, micelles, and a natural product from green tea
(University of Missouri--Columbia, 2012)
Matrix metalloproteinase (MMP-12) is associated with many costly, life-threatening diseases, such as atherosclerosis, pulmonary emphysema, asthma, and multiple sclerosis. Therefore, macrophage secreted MMP-12 is likely ...
Characterizing the retroviral envelope glycoprotein membrane proximal external region and membrane-spanning domains for their roles in helical alignment, fusogenicity, and incorporation into viral particles.
(University of Missouri--Columbia, 2015)
Viruses use surface proteins to gain access into target cells to initiate infection. How these surface proteins make it into assembling viral particles and the exact details of the entry process are poorly understood. My ...
Nitrate and nitrite growth inhibition of Desulfovibrio strains
(University of Missouri--Columbia, 2014)
Sulfate-reducing bacteria, common non-pathogenic soil bacteria, have the ability to limit the movement of toxic heavy metals from one environmental site to another by keeping those metals from dissolving in water. Limiting ...
Characterization of Esrrb function in metastatic prostate cancer cells and transcriptional regulation of hedgehog-signaling pathway target genes
(University of Missouri--Columbia, 2014)
Orphan nuclear receptor Estrogen Receptor Related Receptor Beta (Esrrb) is a transcription factor. Although it was also shown to be important in cancer, little is known about its function in cancer cells and cancer relevant ...
Modification of host and bacterial proteomes during host-pathogen interactions
(University of Missouri--Columbia, 2011)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Plant cells, such as those of Arabidopsis thaliana, detect the presence of bacteria through cell-surface receptors that recognize microbial-associated ...