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Now showing items 21-26 of 26
Novel targeted lipid prodrugs to improve cellular absorption of acyclovir and topical delivery to the eye via nanomicellar approach
(2013)
Biotinylated lipid prodrugs of acyclovir (ACV) were designed to target the
sodium dependent multivitamin transporter (SMVT) on the intestine and cornea to
facilitate ACV cellular transport. All the prodrugs were screened ...
Structural and chemical studies of RNA as anti-cancer target and signaling molecule
(University of Missouri--Kansas City, 2012-01-06)
Ribonucleic acids have been found to have a major role in causation and propagation
of diseases. Targeting such therapeutically important RNA can be a method of treatment of
various diseases. Two such therapeutically ...
Sustained release nanoparticles containing acyclovir prodrugs for ocular herpes simplex keratitis and characterization of folate transport proteins in a corneal epithelial cell line
(University of Missouri-Kansas City, 2011-12-21)
Ocular herpes is a persistent viral infection caused by the herpes simplex virus-1. It is one of
the most common infectious diseases causing corneal blindness in the United States. In this
study, polymeric nanoparticles ...
Development and evaluation of novel in situ depot-forming controlled release formulations
(University of Missouri--Kansas City, 2011-10-24)
Controlled drug delivery utilizing novel biodegradable and biocompatible pentablock copolymers could be a valuable strategy for the treatment of chronic eye diseases. In attempts to achieve controlled drug release, various ...
Design and optimization of nanoformulation loaded with HIV microbicides
(2013)
The objective of this dissertation is to design and optimize nanoformulation for microbicides intended for the prevention of HIV/AIDS transmission. In chapters 1 and 2, the aims and the scope of this work are introduced, ...
Novel drug interaction for improving intracellular accumulation and efficacy of chemotherapeutics in retinoblastoma and mitochondrial localization of transporters in corneal epithelial cells
(University of Missouri--Kansas City, 2013-03-15)
Chemoreduction is the key treatment for retinoblastoma management. However, anticancer agents suffer from poor cell permeability and chemoresistance due to major interaction with multidrug resistant (MDR) efflux proteins ...