pentablock polymers based thermosensitive hydrogel by incorporating PLA block in the center of PEG-PCL-PEG. These polymers were characterized by 1H NMR, GPC, and FT-IR. The effect of block composition on the sol-gel transition, crystallinity, and drug release...

The objective of this study was to develop a clear aqueous mixed nanomicellar formulation (NMF) of hydrophobic drugs for diabetic macula edema. The hydrophobic drugs include triamcinolone acetonide (TA), fluocinolonce ...

For understanding of biological processes, a spatiotemporal control over these processes is needed. Controlling these processes using light can give us the advantage of a precise control over spacing, timing and degree of ...

Random triblock copolymers (RTB) were successfully synthesized by ring opening copolymerization method. RTB copolymers are composed of FDA approved materials such as polyethylene glycol (PEG), glycolide (GA), lactide ...

The effects of pressure and temperature on the yield strength of tantalum and the effects of pressure on the yield strength of rhenium were investigated using ruby fluorescence. A new Raman system with a motorized stage ...

The objective of this dissertation is to develop siRNA-based cancer therapeutics. In chapters 1 and 2, we introduced the mechanism, challenge and promise of RNAi-based therapy, as well as various siRNA delivery systems. ...

, gatifloxacin. A second dimension involved screening in the presence and absence of cefoxitin to identify synergistic agents. Several drugs exhibited synergy with cefoxitin against MRSA that includes floxuridine, gemcitabine, novobiocin, rifaximin and 4...

The objective of this dissertation is to develop a protein-based siRNA nanocomplex for the treatment of alcoholic liver fibrosis. Our laboratory recently discovered that silencing the poly (rC) binding protein 2 (PCBP2) ...

Mathematical analysis in chemistry is a fascinating and critical tool to explain experimental observations. In this dissertation, mathematical methods to present chemical bonding and other structures for many-particle ...

Multidrug resistance (MDR), a clinical outcome characterized by subtherapeutic intracellular drug concentration, is one of the predominant factors limiting effective cancer chemotherapy. Several possible mechanisms and ...

) and in vitro cytotoxicity studies in corneal, conjunctival and retinal cell-lines. Newly synthesized polymers were purified and characterized for their structure and molecular weights by H¹-NMR and GPC, respectively. The CMCs were found to be 0.13, 4.48 and 6...

Macular edema (ME) is caused by central extravascular swelling of the macula resulting in a significant loss of visual activity. Corticosteroids are widely used in the treatment of ME. In this project, nanoparticles of ...

. Seventy-four medium grained sand samples were contaminated with TCE and gasoline at about 25%, 50% and 100% saturation levels for 2, 4, 8, 16, and 32 weeks. In addition, five sand samples were fully saturated with BTEX and isooctane for eight weeks...

Polymerases and ribonucleic acids have been found to play major roles in the causation and progression of several diseases. Targeting such important therapeutic targets using small molecules can help achieve their specific ...

Water contaminated with heavy metals, arsenic, and other industrial pollutants poses a severe risk to human health. Reactive media present an opportunity to intercept contaminants but have high material or environmental ...