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Derivation and characterization of LIF and FGF2 dependent Porcine Induced Pluripotent Stem Cells [abstract]
(2010-02)
. Currently, the ability of LIF-piPSC to give rise to teratoma and chimeras is under investigation. Supported by Missouri Life Sciences Board Grant 00022147 and NIH grant HD21896....
Shock Wave Based Cell Transfection and Fluorescent Organosilicate Nanoparticles for Targeted Drug Delivery [abstract]
(2010)
Nanotechnology is a multidisciplinary field that has applications in life sciences, alternative energy, national defense, and electronics. In the field of medicine, nanotechnology may enable intelligent drug delivery using multifunctional...
Science Outreach and Informal Science Education-Programs and Partnerships [abstract]
(2010-02)
over 145 presentations with approximately 18,000 total attendees. Science Talks to You (STTY) is SMS's new off-campus offshoot. Like SMS, STTY will feature direct engagement between established scientists and the public, but in venues around Missouri...
Development and characterization of fluorescent dye-doped nanoparticles with enhanced fluorescence intensity and photostability [abstract]
(2010)
We report the development of fluorescent dye doped organosilicate nanoparticles (DOSNPs) synthesized from poly-methylsilsesquioxane(PMSSQ), resulting in high fluorescence intensity and excellent photostability. The surface ...
Novel Nanostructured Organosilicate Nanoparticle Coatings for Chem-Bio Sensing [abstract]
(2010-03)
We present novel nanostructured organosilicate particulate based films and demonstrate that these materials have a great potential for chemical-biological sensor development. With unprecedented high surface areas (> 1400 ...
Self-Aligned Microchip Device for Automated Measurement of Quantal Exocytosis [abstract]
(2010-02)
Neurons and endocrine cells secrete neurotransmitters and hormones as a method for cell-to-cell communication through the process of exocytosis. Disruption of exocytosis underlie neurological disorders such as Parkinson's ...
Leveraging Particle Size and Structure to Control Release of Pharmaceuticals for Human and Animal Health [abstract]
(2010)
less costly than developing a new drug altogether. This approach optimizes product life cycle by extending patent protection by 10-15 years and recapturing much of the 60-75% drop in revenue attributable to competition from generics. In one example...
High Resolution Crystal Structure of KD-247, a Humanized Antibody that Inhibits HIV Entry [abstract]
(2010-02)
by the antigen-binding region of the antibody. Molecular docking experiments of a pre-existing structure of the V3-loop target at the presumed binding pocket on KD-247 suggest possible molecular interactions involved in HIV resistance to KD-247 and clade B...
Brain Science and Living Neuronal Networks for Smart Grids [abstract]
(2010)
The objective of this multi-disciplinary collaborative research is to infuse more neurobiology into control systems, to make them more brain-like and better able to carry out real-time control of complex systems. This ...
INFORMER: A System for Immediate and Direct Notification of Critical Data for Patient Care [abstract]
(2010)
serves the purpose, has a number of ordinary to serious limitations such as a higher error rate, incorrect destination, security breach, etc., that could endanger patients life. For example, it is quite possible that the person responsible...
An Electro-magnetic cell stimulator [abstract]
(2010-03)
similar to the ones observed in heat shock experiments (see abstract by Romero et al). The EStim device consists of three sections: the controller, the high-voltage generation unit and the high-current generation unit. The controller is built around...
Selective Laser Sintering and Freeze Extrusion Fabrication of Bioglass Bone Scaffolds [abstract]
(2010)
-freezing temperature environment. The FEF system, developed at Missouri S&T, consists of a 3-axis positioning system, a ram extruder for paste extrusion, and position and force sensors for measurement and control. Bioglass slurry was prepared by ball milling 13...
Development of Absorption and Fluorescence Probes Based on Mouse Model for Molecular Optical Imaging [abstract]
(2010)
In this work we summarize our collaborative research on a project to develop absorption and fluorescence targeting probes. Several groups from University of Missouri and Harry S. Truman Memorial Veteran's Hospital including Dr. Ma's group, Dr. Yu...
Comparative oncology and clinical translation of glyco protein conjugated gold nano therapeutic agent (GA-198AuNP) [abstract]
(2010)
As part of our efforts toward clinical translation of GA-198AuNP, our studies are focused on therapeutic efficacy of nanoparticulate GA198AuNP agent in dogs with prostatic carcinoma. The overall goal is to gain clinical ...
Inhibition Mechanism of EFdA, a Highly Potent Inhibitor of HIV Reverse Transcriptase [abstract]
(2010-02)
The nucleoside 4'-ethynyl-2-fluoro-deoxyadenosine (EFdA) is one of the most
potent antiretroviral nucleosides yet described, inhibiting replication of wild-type and multidrug-resistant HIV-1 strains in vitro (PBMC cells) ...
Novel inhibitors of Foot and Mouth Disease Virus (FMDV) Targeting the RNA-Dependent RNA Polymerase activity of 3Dpol [abstract]
(2010-03)
Foot-and-Mouth Disease Virus (FMDV) is a positive stranded picornavirus which infects cloven-hoofed animals, such as cattle, pigs and sheep, and leads to severe losses in livestock production. In the case of an FMD outbreak, ...
Acid-sensing ion channels as a novel target for drug addiction [abstract]
(2010-03)
Improving the treatment and prevention of drug addiction is an important goal for modern medicine. Ion channels have recently become very attractive targets in the search of new pharmacotherapies. Extracellular proton ...
Slipped deadlines and sample size shortfalls in clinical trials: a proposed remedy using a Bayesian model with an informative prior distribution [abstract]
(2010-03)
Background: The most common reason why clinical trials fail is that they fall well below their goals for patient accrual. Researchers will frequently overpromise and underdeliver on the number of patients that they can ...
Discovery and Mechanistic Characterization of Novel SARS Coronavirus Inhibitors that Block Viral Entry [abstract]
(2010-03)
Severe acute respiratory syndrome (SARS) is an infectious and highly contagious disease that is caused by SARS-associated coronavirus (SARS-CoV). Viral entry is a key target step for therapies because it can prevent the ...
Pancreatic islet transplantation to treat diabetes - defining molecular tools to select suitable islets [abstract]
(2010)
A complete understanding of pancreatic islet biology is essential to the development of preventive or curative interventions for diabetes. It has been known that subpopulations of islets of different sizes exist; however, ...