Evidence is presented for three important DNA metabolic processes which may direct genetic recombination events during meiosis. These processes are: 1) DNA breakage and repair, 2) facilitated interaction between homologous ...

Three ontogenetic origins of antibody diversity have been identified. First, there is a large number of germline gene segments. Second, multiple combinatorial strategies are used to amplify antibody diversity. These include ...

The interferon system is amenable to somatic cell genetic analysis since the genes governing the synthesis of interferon and the cellular responses to interferon can be expressed in tissue culture cells. Limited species ...

Genetic diseases and birth defects have a major impact on all levels of health care because of their enormous consequences for the individual and family and because of the high frequency of occurrence. That over 3000 ...

Somatic cell genetics is an application of the concepts and techniques of microbial genetics to somatic cells of higher organisms. Applied to mammalian systems, it has made possible clone isolation, quantitation of cell ...

Structural aspects of ribosomal and non-ribosomal RNA transcription are compared and contrasted in a representative prokaryote (Escherichia coli) and in several diverse eukaryotes (developing amphibian oocytes, Drosophila ...

Mitotic recombination (MR) chromosomes are geographically widespread and occur in high frequency in wild Drosophila melanogaster populations. In both sexes, MR chromosomes increase the frequency of mitotic recombination ...

The genetic diseases of man constitute a unique challenge to the medical scientist. For the past several years our laboratory has been developing new drugs for two of the more common genetic diseases - sickle cell anemia ...

Recombinationless (rec) mutants of bacteria are sensitive to visible and near-ultraviolet wavelengths of light. In addition, these mutants are sensitive to a tryptophan photoproduct that results from irradiation of this ...

The impact of the developing science of human genetics on society will produce social conflicts and raise social questions which require legal solutions. Particular problems are limitations on human experimentation; legal ...

Properties of nucleoids isolated from Escherichia coli are described. Experiments which investigate the organization of DNA folding and supercoiling in the isolated chromosome are reviewed, and evidence is discussed ...

This discussion will be concerned with two aspects of genetic variability in populations of plants: (1) the extent of genetic variability within the local population, and the patterns in which genetic variability occurs ...

Three factors provide unusual opportunities for potato improvement: (1) The wild and cultivated tuber-bearing relatives of the potato represent a large source of valuable germplasm. This genetic diversity can be incorporated ...