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Novel chemical mechanisms of DNA damage by natural products
(University of Missouri--Columbia, 2007)
that the molecule is very toxic to human pancreatic carcinoma cell line (MiaPaCa) and fragments DNA extensively with an IC[subscript 50] of 50 nM. The elucidation of molecular mechanism behind the rapid depurination event might help to understand more about...
Synthesis and photochemistry of PT (IV) hydroxo complexes
(University of Missouri--Columbia, 2015)
Global energy consumption and the production of clean renewable energy have become greater challenges. Sunlight-induced splitting of water into H2 and O2 is one of the leading strategies to achieve clean and renewable ...
Synthesis and evaluation of 105Rhodium(III) complexes derived from diaminodithioether (DADTE) ligands
(University of Missouri--Columbia, 2006)
Seven analogoues of tetradentate acyclic diaminodithioether (DADTE)ligands were synthesized and characterized. R₂SC(R₁)₂)CHnN(CH₂)mNCHn((R₁)₂C)SR₂ 222-gdm (L3): m = 1, n = 1, R₁ = -CH₃ and R₂ = -H; 222-gdm-pmBz (L4): m = ...
Technetium and rhenium schiff base complexes for nuclear medicine
(University of Missouri--Columbia, 2019)
This dissertation investigates the synthesis of rhenium and technetium Schiff base complexes for potential applications in nuclear medicine. In Chapter 2, a series of mixed ligand Re(III) complexes of the form trans-[Re( ...
Synthesis and reactivity of actinide phosphorano-stabilized carbene and phosphido complexes
(University of Missouri--Columbia, 2018)
Nuclear power plants have been operated in the United States for over 60 years, generating over 800 terawatt-hours of energy per year. However, there is still no reliable process to recycle the spent nuclear fuel. This ...
Atomic-scale studies of chemical and transport processes relevant to propellant combustion
(University of Missouri--Columbia, 2018)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Density functional theory (DFT) and correlated molecular orbital electronic structure calculations were used to study the Al + CO2 [subscript arrow] ...
Investigations into the chemistry of protein tyrosine phosphatase redox regulation
(University of Missouri--Columbia, 2009)
Transmission of complex intracellular signals, such as those for glucose uptake or proliferation, is often accomplished through the reversible phosphorylation of specific protein tyrosine residues. This reversible ...
Biologically relevant chemistry of sulfur heterocycles : from redox regulation of PTP1B to the biological activity of s-deoxy leinamycin
(University of Missouri--Columbia, 2008)
Protein tyrosine phosphatase 1B (PTP1B) is an important member of protein tyrosine phosphatase (PTPs) family that shares a conserved catalytic cysteine thiol residue. PTP1B acts as a negative regulator of insulin mediated ...
High valent uranium dioxo and imido complexes : synthesis and structure
(University of Missouri--Columbia, 2008)
Early actinide elements have attracted considerable attention in recent years due to the need for rigorous advancements in spent nuclear fuel recycling and remediation technologies, and for their emerging versatility in ...