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Which SSRIs most effectively treat depression in adolescents?
(Family Physicians Inquiries Network, 2016)
Q: Which SSRIs most effectively treat depression in adolescents? Evidence-based answer: We don' t know which selective serotonin reuptake inhibitors (SSRIs) are the most effective and safe because no studies have compared ...
Does breastfeeding affect the risk of childhood obesity?
(Family Physicians Inquiries Network, 2016)
breastfeeding rates during the first 3 to 6 months of life don't appear to alter body mass index (BMI) at 11 to 12 years of age (SOR: B, randomized clinical trial [RCT]). Introducing complementary (solid) foods before 3 months is associated with a 30% greater...
Do corticosteroid injections improve carpal tunnel syndrome symptoms?
(Family Physicians Inquiries Network, 2016)
Q: Do corticosteroid injections improve carpal tunnel syndrome symptoms? Evidence-based answer: Yes. injected corticosteroids reduce symptoms of carpal tunnel syndrome (CTS) more effectively than placebo or systemic steroids, ...
Hypoglycemia with insulin and sulfonylureas
(Family Physicians Inquiries Network, 2020)
Clinical Inquiries question: In patients with type 2 diabetes mellitus (T2DM), does the combination of insulin and sulfonylurea (SU) increase the risk of hypoglycemia? Evidence-based answer: The incidence of severe hypoglycemia in patients with T2DM...
Which treatments are safe and effective for chronic sinusitis?
(Family Physicians Inquiries Network, 2016)
Q: Which treatments are safe and effective for chronic sinusitis? Evidence-based answer: for adults with chronic rhinosinusitis (crs), intranasal steroid (ins) therapy is more likely than placebo to improve symptoms (50% ...
Which nonhormonal treatments are effective for hot flashes?
(Family Physicians Inquiries Network, 2016)
Q: Which nonhormonal treatments are effective for hot flashes? Evidence-based answer: Selective serotonin reuptake inhibitors (SSRIs [fluoxetine, sertraline, paroxetine]) and the selective norepinephrine reuptake inhibitor ...
Which patients with metabolic syndrome benefit from metformin?
(Family Physicians Inquiries Network, 2016)
Q Which patients with metabolic syndrome benefit from metformin? Evidence-based answer: Patients at highest risk for progression to diabetes benefit from metformin. In patients with metabolic syndrome who are in the ...
When to "CAP" off treatment for pneumonia
(Family Physicians Inquiries Network, 2017)
clinical success rates as longer treatment regimens, but is associated with fewer negative patient outcomes....
Confidently rule out CAP in the outpatient setting
(Family Physicians Inquiries Network, 2021)
) -- without requiring a chest x-ray -- in an otherwise healthy adult outpatient who has an acute cough, a normal pulmonary exam, and normal vital signs using this simple clinical decision rule (CDR). STRENGTH OF RECOMMENDATION: A: Based on a systematic review...
Need an add-on to metformin? Consider this
(Family Physicians Inquiries Network, 2017)
Need an add-on to metformin? Consider this. Sulfonylureas have been the preferred add-on therapy to metformin for T2DM, but a study finds that DPP-4s have lower risks of death, CV events, and hypoglycemia. Practice changer: ...
Does vitamin D without calcium reduce fracture risk?
(Family Physicians Inquiries Network, 2016)
Q: Does vitamin D without calcium reduce fracture risk? Evidence-based answer: No. Supplemental vitamin D without calcium -- in doses averaging as much as 800 IU per day -- doesn't reduce the risk of hip, vertebral, or ...
Association of first-line antidepressants and incident adverse metabolic effects
(Family Physicians Inquiries Network, 2020)
Clinical Inquiries question: Are first-line antidepressants associated with incident adverse metabolic effects in adults? Evidence-based answer: Selective serotonin reuptake inhibitors (SSRIs) and bupropion statistically significantly increase...
What's the best treatment setting for stable PE patients?
(Family Physicians Inquiries Network, 2018)
What's the best treatment setting for stable PE patients? The answer seems to be the outpatient setting. Here's why. PRACTICE CHANGER: Manage patients with acute pulmonary embolism (PE) who are hemodynamically stable in ...
Is it better to take that antihypertensive at night?
(Family Physicians Inquiries Network, 2020)
A large RCT in a primary care setting comparing bedtime to upon-waking administration of antihypertensives answers the question. PRACTICE CHANGER: Advise patients to take blood pressure (BP) medication at bedtime rather ...
Efficacy of a low-carbohydrate or ketogenic diet in preventing patient morbidity and mortality
(Family Physicians Inquiries Network, 2020)
Clinical Inquiries question: What is the efficacy of a low-carbohydrate or ketogenic diet in the prevention of patient morbidity and mortality? Evidence-based answer: Ketogenic diets can reduce seizure incidence in refractory epilepsy (strength...
Getting a jump on recovery from sports-related concussion
(Family Physicians Inquiries Network, 2022)
Early subthreshold aerobic exercise safely improved recovery time over a stretching regimen among adolescents in this clinical trial....
How often does long-term PPI therapy cause clinically significant hypomagnesemia?
(Family Physicians Inquiries Network, 2018)
Q: How often does long-term PPI therapy cause clinically significant hypomagnesemia? EVIDENCE-BASED ANSWER: Rarely. Proton pump inhibitors (PPIs) may be associated with decreases in serum magnesium laboratory values to below 1.6 to 1.8 mg...
Can drinking more water prevent urinary tract infections?
(Family Physicians Inquiries Network, 2020)
Can drinking more water prevent urinary tract infections? A high-quality randomized controlled trial says 'Yes'. PRACTICE CHANGER: Advise premenopausal women with recurrent urinary tract infections (UTIs) and low-volume ...
Steroids during late preterm labor: better later than never
(Family Physicians Inquiries Network, 2017)
Steroids during late preterm labor: Better later than never. Steroids--even when administered in the last leg of the late preterm period--still reduce the likelihood of respiratory complications in newborns. Practice ...
Consider this tool to reduce antibiotic-associated adverse events in patients with sepsis
(Family Physicians Inquiries Network, 2023-01)
For patients hospitalized with sepsis, consider procalcitonin (PCT)-guided early discontinuation of antibiotic therapy for fewer infection-associated adverse events (AEs).