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Molecular mechanism, binding free energy, and sequence selectivity of intercalation of doxorubicin and DNA
(2021)
Many drugs interact noncovalently with DNA either by groove binding or intercalation. Intercalation is a key process in drug discovery and biosensor development. Doxorubicin (DOX) is an intercalator drug that treats a wide ...
Associations between genetic risk for trait aggression and alcohol use predicting alcohol-related aggression
(University of Missouri--Columbia, 2021)
A propensity for aggression and/or alcohol use may be associated with alcoholrelated aggression. Previous research has shown genetic overlap between alcohol use and aggression, but has not looked at how alcohol-related ...
Ratiometric techniques to determine fluid viscosity using molecular rotors
(University of Missouri--Columbia, 2007)
Molecular rotors exhibit viscosity-dependent quantum yield, potentially allowing measurements of fluid viscosity in non-mechanical manner. Several diseases are accompanied by blood plasma viscosity changes; therefore, a ...
Joint Estimation of Sequential Labor Force Participation and Fertility Decisions Using Markov Chain Monte Carlo Techniques
(Department of Economics, 2004)
In this paper we estimate the causal effect of children on the labor supply of women using panel data on women from the 1979 National Longitudinal Survey of Youth (NLSY79). We examine the effect of children both prior to ...
The importance of the supplementation of zinc in nursey pig diets
(University of Missouri--Columbia, 2006)
Two 28-d experiments were conducted to investigate the effect of feeding pharmacological concentrations of Zn, from organic and inorganic sources, on growth performance and intestinal microbial population in nursery pigs. ...
Soybean seed components as affected by nodal position, environmental conditions, and irrigation
(University of Missouri--Columbia, 2005)
Soybeans (Glycine max [L.] Merr.) are a major source of vegetable protein and edible oil. The nutritional quality of these seed components depends upon the relative abundance of specific proteins and fatty acids. Additionally, ...
Noise and signal transmission properties as agents of selection in the vibrational communication environment
(University of Missouri--Columbia, 2007)
Members of the Enchenopa binotata species complex (Hemiptera: Membracidae) are host-specific phytophagous insects that communicate by sending vibrations through their host plants. Successful communication depends on the ...
Genetic basis of isoflavone accumulation during soybean seed development : special focus on water-deficit conditions
(University of Missouri--Columbia, 2009)
Soybean (Glycine max [L] Merr.) seed isoflavones have long been considered a desirable trait to target in selection programs for their contribution to human health and plant defense systems. The plant synthesizes isoflavones ...
Longitudinal assessment of age-related change in the dental pulp chamber and age estimation using dental radiographs
(University of Missouri--Columbia, 2007)
.82, for 45 subjects aged 17 to 86 years in an independent test set. Mean error of estimated age was 0.08 years (SD 8.3 years). In contrast, longitudinal premolar pulp chamber sizes typically showed Pearson correlations to age of r [almost equal to] -0...
How reliable are self-measured blood pressures taken at home?
(Family Physicians Inquiries Network, 2004)
Self-measured blood pressures (SMBP) can be precise and accurate and, thus, reliably be used as an adjunct to office blood pressure measurements in selected clinical situations (strength of recommendation [SOR]: B, ...
Examining dissolution procedure effects on trace and rare earth element concentrations and U/Pb ages in conodonts
(University of Missouri--Columbia, 2022)
The ability to quantitatively date carbonate rocks and shales using geo- and thermochronometry has eluded geologists due to the scarcity of requisite minerals. A small number of investigations have shown that the highly ...
Evaluating the suitability of the human toenail as a biomonitor for manganese status: the one source cohort
(University of Missouri--Columbia, 2007)
Numerous studies have demonstrated that the human toenail is a reliable biomonitor for the intake of Se and other elements. The objective of this study was to evaluate the hypothesis that Mn intake is reflected in toenail ...
Response of beef cattle selected for tolerance to tall fescue toxicosis
(University of Missouri--Columbia, 2019)
Tall fescue (Schedonorus arundinaceus (Schreb.) Dumort.) infected with the endophytic fungus, Epichlooجا coenophiala [(Morgan-Jones & W. Gams) C.W. Bacon & Schardl, comb. nov.] produces ergot alkaloids that result in a ...
Evaluation of the efficacy of high levels of microbial phytase in broilers
(University of Missouri--Columbia, 2006)
Three experiments were conducted to evaluate the efficacy of high levels of microbial phytase in broiler diets. In experiment one (EXP 1), phytase was included in the diets at 0, 250, 500, 10,000, and 20,000 PU/kg diet. ...
Effects of continous administration of low-dose of Escherichia coli lipopolysaccharide in chicks and poults fed non toxic doses of aflatoxin B1 and T-2 toxin
(University of Missouri--Columbia, 2005)
Six studies (three with broilers and three with turkeys) were conducted to determine if E. coli lipopolysaccharide (LPS) would enhance the effects of aflatoxin B1 (AFB1) and the T-2 toxin (T-2) in chicks and poults fed ...
Dopamine and emotion processing in schizotypal anhedonia
(University of Missouri--Columbia, 2009)
Three studies examined emotion processing and dopamine regulation in anhedonia. In Study 1, in multiple assessments of emotional experience (e.g., naturalistic and lab contexts and social and nonsocial situations), people ...
Optimal designs for dose-finding in contingent response models
(University of Missouri--Columbia, 2004)
We study D- and c-optimal designs for dose-finding with opposing failure functions. In particular, we study the contingent response models of Li, Durham and Flournoy (1995). In the contingent response model, there are two ...
Abundance of TRIM28, SETDB1, and TP53 mRNA is dynamically regulated during porcine early embryogenesis and is abnormal in preimplantation embryos produced by in vitro fertilization in comparison to in vivo derived and nuclear transfer derived embryos
(University of Missouri--Columbia, 2013)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] In vitro embryo production is important for research in animal reproduction, embryo transfer, transgenics, and cloning. However, in vitro-derived embryos ...
An analysis of aspartic peptidases expressed by trophoblasts and placenta of even-toed ungulates
(University of Missouri--Columbia, 2008)
The Pregnancy Associated Glycoproteins (PAGs) represent a multigene family of trophoblast expressed proteins, found exclusively in the placenta of even-toed mammals such as ruminants (cattle, sheep), pig, etc. In ruminants, ...
Genetically Modified Crops and Household Labor Savings in US Crop Production
(AgBioForum, 2009)
In spite of widespread adoption, there is mixed evidence as to whether adopting genetically modified (GM) crops increases farm welfare. One possible reason for widespread adoption is the labor savings. Using a treatment ...