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Now showing items 21-31 of 31
Clear, Aqueous Topical Nanomicelle Formulation For Diabetic Macula Edema
(University of Missouri -- Kansas City, 2018)
The objective of this study was to develop a clear aqueous mixed nanomicellar
formulation (NMF) of hydrophobic drugs for diabetic macula edema. The hydrophobic
drugs include triamcinolone acetonide (TA), fluocinolonce ...
Novel Folic Acid Targeted Nanomicelles For Delivery Of Hydrophobic Drugs To The Back Of The Eye
(University of Missouri -- Kansas City, 2019)
Overall aim of this research project is to develop folic acid targeted nanomicelles
loaded with insoluble hydrophobic drugs for delivery to posterior segment of the eye.
Retinoblastoma and uveitis are diseases that ...
Development of polymeric nanoparticulate formulation encapsulating protein molecules following hydrophobic ion pairing complexation
(2014)
Several formulation strategies have been employed to enable sustained delivery of antibody therapeutics by nanoparticulate based dosage forms. However, development of sustained release nanoparticulate based dosage form for ...
Novel in vitro cell culture models for studying pharmacokinetic drug-drug interactions following oral administration
(University of Missouri--Kansas City, 2011-09-21)
In this study different in vitro models were developed to study the long term and short term drug- drug interactions occurring upon oral administration. MDCK cells were stably transfected for the simultaneous expression ...
Topical Clear Aqueous Nanomicellar Formulation for Anterior and Posterior Ocular Drug Delivery
(University of Missouri–Kansas City, 2015)
The objective of this study was to develop a clear, aqueous drug loaded nanomicellar formulation (NMF) for the back-of-the-eye delivery. Hydrophobic drugs such as cyclosporine, resolvin analog (RX-10045), dexamethasone, ...
Topical Clear Aqueous Nanomicellar Formulations For Anterior And Posterior Ocular Drug Delivery
(2015-08-04)
The objective of this study was to develop a clear, aqueous drug loaded
nanomicellar formulation (NMF) for the back-of-the-eye delivery. Hydrophobic
drugs such as cyclosporine, resolvin analog (RX-10045), dexamethasone ...
Preparation of Pentablock Nanomicellar Formulations for Prostate Cancer Drug Delivery Systems
(University of Missouri -- Kansas City, 2018)
This study is divided into three specific aims. Specific aim #1 focused on
synthesis of pentablock co-polymer using monomers of L-lactide, ε-caprolactone and
ethylene-glycol with varied molecular weights, (ii) ...
Part I: Effect of Nanomicelle Size on Trans-scleral Permeability of Dexamethasone and Part II: Strategies to Minimize Octreotide Acylation during Sustained Release from Biodegradable Polymers
(2015-06-19)
Our primary aim was to determine the effect of nanomicelle size on dexamethasone (DEX) transport across the sclera. Nanomicelles of various sizes were developed and characterized.
Low molecular weight diblock co-polymers, ...
Long Term Ocular Drug Delivery with Novel Pentablock Copolymers; Part I: Composite Nanoformulation of Macromolecules For Back of the Eye Diseases, Part II: Dexamethasone Nanoparticle to Develop an In Vitro Model for Glaucoma
(University of Missouri -- Kansas City, 2017)
Pentablock (PB) copolymers have been successfully synthesized for long term delivery in
the treatment of posterior segment ocular diseases. PB copolymers are comprised of FDA
approved biodegradable polymer such as ...
Prodrug Approach to Improve Oral and Brain Absorption of HIV Protease Inhibitor, Lopinavir
(2014)
The main objective of this project is to develop prodrug strategies to circumvent efflux
pumps such as P-glycoprotein (P-gp) and multidrug resistance associated proteins (MRPs),
thereby enhancing oral and brain absorption ...
Stereoisomeric Prodrugs to Improve Ocular And Oral Absorption of Prednisolone
(2015-08-11)
The primary objective of this project is to develop stereoisomeric prodrugs such as Lvaline-
D-valine-prednisolone (LDP) and D-valine-L-valine-prednisolone (DLP) to improve
ocular and oral absorption of prednisolone. ...