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Suppression of nitric oxide induction and pro-inflammatory cytokines by novel proteasome inhibitors in various experimental models
(2011-10-12)
Abstract
Background
Inflammation has been implicated in a variety of diseases associated with ageing, including cancer, cardiovascular, and neurologic diseases. We have recently established that the proteasome ...
Inhibition of nitric oxide in LPS-stimulated macrophages of young and senescent mice by delta-tocotrienol and quercetin.
(2011-12-20)
Abstract
Background
Changes in immune function believed to contribute to a variety of age-related diseases have been associated with increased production of nitric oxide (NO). We have recently reported that ...
Encapsulation of docetaxel in oily core polyester nanocapsule intended for breast cancer therapy
(2011-12-14)
Abstract
This study is designed to test the hypothesis that docetaxel [Doc] containing oily core nanocapsules [NCs] could be successfully prepared with a high percentage encapsulation efficiency [EE%] and high drug loading. ...
Association of 25-hydroxyvitamin D deficiency with NT-pro BNP levels in patients with acute myocardial infarction: a cross-sectional analysis
(2011-12-15)
Abstract
Background
Nutritional vitamin D deficiency is an emerging risk factor for acute myocardial infarction (AMI) and heart failure. The association of 25-hydroxyvitamin D levels with N-terminal pro B-type natriuretic ...
GAL1-SceI directed site-specific genomic (gsSSG) mutagenesis: a method for precisely targeting point mutations in S. cerevisiae.
(2011-12-05)
Abstract
Background
Precise targeted mutations are defined as targeted mutations that do not require the retention of other genetic changes, such as marker genes, near the mutation site. In the yeast, S. cerevisiae, ...
Comparative genome sequence analysis underscores mycoparasitism as the ancestral life style of Trichoderma
(2011-04-18)
Abstract
Background
Mycoparasitism, a lifestyle where one fungus is parasitic on another fungus, has special relevance when the prey is a plant pathogen, providing a strategy for biological control of pests for plant ...
Insights into the pathogenesis of axial spondyloarthropathy from network and pathway analysis
(2012-07-16)
Abstract
Background
Complex chronic diseases are usually not caused by changes in a single causal gene but by an unbalanced regulating ...
Silencing of the IKKepsilon gene by siRNA inhibits invasiveness and growth of breast cancer cells
(2010-09-23)
Abstract
Introduction
IκB kinase ε (IKKε) is a member of the IKK family that plays an important role in the activation of NF-κB. Overexpressed in more than 30% of breast cancers, IKKε has been ...
Investigation of 95 variants identified in a genome-wide study for association with mortality after acute coronary syndrome
(2011-09-29)
Abstract
Background
Genome-wide association studies (GWAS) have identified new candidate genes for the occurrence of acute coronary syndrome (ACS), but possible effects of such genes on survival following ACS ...
TRIP-1 via AKT modulation drives lung fibroblast/myofibroblast trans-differentiation
(2014-02-15)
Abstract
Background
Myofibroblasts are the critical effector cells in the pathogenesis of pulmonary fibrosis which carries a high degree of morbidity and mortality. We have previously identified ...
Meta-analysis of molecular response of kidney to ischemia reperfusion injury for the identification of new candidate genes
(2013-10-24)
Abstract
Background
Accumulated to-date microarray data on ischemia reperfusion injury (IRI) of kidney represent a powerful source for identifying new targets and mechanisms of kidney IRI. In ...
Investment into the future of microbial resources: culture collection funding models and BRC business plans for biological resource centres
(2014-02-12)
Through their long history of public service, diverse microbial Biological Resource Centres (mBRCs) have made myriad contributions to society and science. They have enabled the maintenance of specimens isolated before ...
Involvement of metabotropic glutamate receptor 5, AKT/PI3K Signaling and NF-kappaB pathway in methamphetamine-mediated increase in IL-6 and IL-8 expression in astrocytes
(2012-03-15)
Abstract
Methamphetamine (MA) is one of the commonly used illicit drugs and the central nervous system toxicity of MA is well documented. The mechanisms contributing to this toxicity have not been fully elucidated. In this ...
Increased Mortality among Survivors of Myocardial Infarction with Kidney Dysfunction: the Contribution of Gaps in the use of Guideline-Based Therapies
(2009-07-08)
Abstract
Background
We assessed the degree to which differences in guideline-based medical therapy for acute myocardial ...
delta-Tocotrienol and quercetin reduce serum levels of nitric oxide and lipid parameters in female chickens
(2011-02-28)
Abstract
Background
Chronic, low-grade inflammation provides a link between normal ageing and the pathogenesis of age-related diseases. A series of in vitro tests confirmed the strong anti-inflammatory activities ...
The role of Candida albicans homologous recombination factors Rad54 and Rdh54 in DNA damage sensitivity
(2011-09-27)
Abstract
Background
The fungal pathogen Candida albicans is frequently seen in immune suppressed patients, and resistance to one of the most widely used antifungals, fluconazole (FLC), can evolve rapidly. In recent years ...
Motivational Interviewing for encouraging quit attempts among unmotivated smokers: Study protocol of a randomized, controlled, efficacy trial.
(2012-06-19)
Abstract
Background
Although the current Clinical Practice Guideline recommend Motivational Interviewing for use with smokers not ready to quit, the strength of evidence for its use is rated ...
Tocotrienols-induced inhibition of platelet thrombus formation and platelet aggregation in stenosed canine coronary arteries.
(2011-04-14)
Abstract
Background
Dietary supplementation with tocotrienols has been shown to decrease the risk of coronary artery disease. Tocotrienols are plant-derived forms of vitamin E, which have potent anti-inflammatory, ...
Glucocorticoid-like effects of antihepatocarcinogen Rotenone are mediated viaenhanced serum corticosterone levels: Molecular Fitting and Receptor Activation Studies
(2003-02-14)
Abstract
Background
Recent studies suggest that rotenone alters cell signal transduction pathways in a manner similar to glucocorticoids. ...
Determination of iron sucrose (Venofer) or iron dextran (DexFerrum) removal by hemodialysis: an in-vitrostudy
(2004-01-12)
Abstract
Background
Intravenous iron is typically administered during the hemodialysis (HD) procedure. HD patients may be prescribed ...