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Now showing items 41-60 of 97
Characterizing the retroviral envelope glycoprotein membrane proximal external region and membrane-spanning domains for their roles in helical alignment, fusogenicity, and incorporation into viral particles.
(University of Missouri--Columbia, 2015)
Viruses use surface proteins to gain access into target cells to initiate infection. How these surface proteins make it into assembling viral particles and the exact details of the entry process are poorly understood. My ...
Characterization of Esrrb function in metastatic prostate cancer cells and transcriptional regulation of hedgehog-signaling pathway target genes
(University of Missouri--Columbia, 2014)
Orphan nuclear receptor Estrogen Receptor Related Receptor Beta (Esrrb) is a transcription factor. Although it was also shown to be important in cancer, little is known about its function in cancer cells and cancer relevant ...
Nitrate and nitrite growth inhibition of Desulfovibrio strains
(University of Missouri--Columbia, 2014)
Sulfate-reducing bacteria, common non-pathogenic soil bacteria, have the ability to limit the movement of toxic heavy metals from one environmental site to another by keeping those metals from dissolving in water. Limiting ...
The role of Rex in regulation of sulfate reduction in Desulfovibrio vulgaris Hildenborough
(University of Missouri--Columbia, 2014)
Although the enzymes for dissimilatory sulfate reduction by microbes have been studied, the mechanism for transcriptional regulation of the encoding genes remain unknown. In the work presented here, the model sulfate-reducing ...
[alpha]A-crystallin derived peptide, [alpha]A66-80 induced aggregation and precipitation of soluble [alpha]-crystallin : a contribution to age-related cataract formation
(University of Missouri--Columbia, 2013)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Age-related cataract is the result of aggregation of lens proteins, crystallins. The formation of aggregates in the aging lens has been shown to correlate ...
The copper ATPases : intracellular trafficking and nervous system function
(University of Missouri--Columbia, 2013)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Copper is essential for life, as it participates as a cofactor in numerous enzymatic reactions including energy generation, antioxidant defense, ...
Pamp triggered responses as the first layer of immunity reprogramming cells for defense in both mammals and plants
(University of Missouri--Columbia, 2013)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Both mammals and plants live in a constant co-existence with a broad range of microbes. Some of these microbes have the potential to be pathogenic and ...
Targeting estrogen- and hedgehog-signaling pathways in prostate cancer
(University of Missouri--Columbia, 2009)
Prostate cancer is the second most frequent cause of cancer deaths in men, and the risk to develop cancer increases with age. Since the lifespan of the society is progressively increasing, the importance of preventing the ...
The influence of mRNA secondary structures on ribosome conformational dynamics
(University of Missouri--Columbia, 2016)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Synthesizing proteins in the cell is a critical aspect of life. Protein synthesis is a complicated process and involve highly functional machines at a ...
Structural studies of inhibition and resistance mechanism of EFDA, a human immunodeficiency virus reverse transcriptase inhibitor
(University of Missouri--Columbia, 2016)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.]
Protein components of the microbial mercury methylation pathway
(University of Missouri--Columbia, 2015)
Mercury (Hg) in the environment and the resulting methylmercury (CH3Hg+) produced by microorganisms has emerged as a global concern in the last 50 years after a series of high profile, large scale contamination events, ...
Stability, states, and interactions of the enzyme PMM/PGM by NMR and multivariate analysis
(University of Missouri--Columbia, 2016)
Phosphomannomutase/phosphoglucomutase (PMM/PGM) contributes to the infectivity of an opportunistic human pathogen Pseudomonas aeruginosa by participating in carbohydrate biosynthesis. As a phospho-transfer enzyme, PMM/PGM ...
Study of PVCA and PVCB, two enzymes involved in making isonitrile-containing natural products in bacterial pathogens
(University of Missouri--Columbia, 2016)
Isonitriles, with an unusual functionality, are very versatile intermediates widely involved in organic synthesis. Interestingly, a variety of isonitriles were encountered in both marine and terrestrial systems as the ...
Interaction of secretory protein SecA with its binding partners : lipids and SecB
(University of Missouri--Columbia, 2016)
Thirty percent of proteins synthesized in the cytoplasm of E.coli are exported across or into the cytoplasmic membrane to reach their final destinations. The general secretory system exports precursor proteins through the ...
Aptamers that bind filovirus GP : a new frontier for detection and neutralization of Ebola and Marburg virus
(University of Missouri--Columbia, 2020)
Aptamers are single chained, nucleic acid-based affinity probes that bind to their targets with strong affinity and specificity. They are made through an in vitro combinatorial selection method, wherein large libraries of ...
Characterization of the effects of 3,3'-diindolylmethane (DIM) in the TRAMP mouse prostate cancer model and DIM's interaction with estrogen receptor signaling
(University of Missouri--Columbia, 2018)
3,3'- diindolylmethane (DIM) is an acid -derived compound formed during the digestion of indole-3-carbinol (I3C), which is one of the main compounds in cruciferous vegetables, such as broccoli, cabbage and kale. Studies ...
A novel role for the ATP7A copper transporter in cancer
(University of Missouri--Columbia, 2018)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Copper is a trace metal with a ready capacity to gain or donate electrons. This property is harnessed by numerous enzymes to perform vital functions ...
Characterizing the roles of an Arabidopsis Epsin n-terminal homology domain protein in plant innate immunity
(University of Missouri--Columbia, 2015)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The plasma membrane (PM) serves as a crucial point of contact between a plant cell and its environment. Localized at this critical interface are proteins ...
Making others happy : the best route to one's own happiness?
(University of Missouri--Columbia, 2017)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] There are many positive psychology interventions whose aim is to help people improve their levels of happiness and well-being, some of which work ...
The musculoskeletal effect of exercise and soluble activin receptor type 2b in mouse models of osteogenesis imperfecta
(University of Missouri--Columbia, 2017)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Osteogenesis Imperfecta (OI) is a heritable connective tissue disorder primarily due to mutations in the type I collagen containing tissues, such as ...