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Now showing items 41-47 of 47
Chemical mechanisms of DNA damaging natural products
(University of Missouri--Columbia, 2011)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Natural products provide both novel molecular structures and new mechanisms that have significant therapeutical implications. The work described here ...
Formal total synthesis of pseudopteroxale : progress toward total synthesis of hamigeran B
(University of Missouri--Columbia, 2011)
In the first chapter, a formal total synthesis of pseudopteroxazole is presented, highlightening an E-selective Horner-Emmons reaction, a Buchwald-Hartwig coupling, and a diastereoselective intramolecular Michael addition. ...
Synthesis of fluorescent 7-amino-2,1-benzothiazines and total synthesis of buddledone A
(University of Missouri--Columbia, 2011)
The development of new fluorescent compounds has been reported continuously due to their application as sensors and optical devices for material, biological and chemical applications. This dissertation reports the syntheses ...
Determination of trace elements levels in human plasma and radiated mice tongue by inductively coupled plasma-mass-spectrometry (ICP-MS)
(University of Missouri--Columbia, 2012)
An analytical method that uses a minimum150 μL of human plasma samples for the trace elements Fe, Cu, Zn, Mg and ultratrace elements Mn, Co, Cd, Pb was developed. The method was evaluated using both high resolution sector ...
Development of long wavelength fluorescent sensors
(University of Missouri--Columbia, 2011)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The design, synthesis and spectroscopic properties of several long wavelength/NIR fluorescent sensors are discussed. Amongst them, the metal ...
Structural basis of substrate recognition and inactivation in phosphatases
(University of Missouri--Columbia, 2011)
Phosphatases are ubiquitous enzymes that catalyze the transfer of phosphoryl group to water. In addition to being one of the most important and fundamental reactions in biological systems, phosphatases are critical to ...
Preparation of polymeric boron-containing nanoparticles by emulsion polymerization for application in boron neutron capture therapy (BNCT)
(University of Missouri--Columbia, 2010)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Boron neutron capture therapy (BNCT) is based on the nuclear capture reaction of isotope [superscript 10]B irradiated by low energy thermal neutron ...