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Now showing items 41-60 of 105
Development and application of inductively coupled plasma mass spectrometry techniques to investigate platinum chemotherapy agents
(University of Missouri--Columbia, 2010)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Cisplatin (cDDP), the first platinum chemotherapy compound, has been used in cancer chemotherapy in human beings and animals for more than thirty ...
Quantum aspects of roaming dynamics
(University of Missouri--Columbia, 2020)
Decades of experimental and theoretical achievements built on the foundations of thermochemistry and quantum mechanics have birthed the field of molecular dynamics where intimate details of individual reactive events can ...
Structural and kinetic studies of human aldh7a1 and aldh9a1
(University of Missouri--Columbia, 2021)
The regulation and detoxification of endogenously and exogenously derived aldehydes is paramount to cellular survival due to the highly reactive nature of aldehydes as electrophiles. Human aldehyde dehydrogenases (ALDHs) ...
A comparison of some methods of estimating radium
(University of Missouri--Columbia, 1914)
The quantitative determination of the small amounts of radium present in the atmosphere, spring waters, minerals and rocks involves two steps: (1) The quantitative separation of the radium emanation in a known weight of ...
Metabolically activated heterocyclic N-oxide compounds for killing and visualizing hypoxic cancer cells
(University of Missouri--Columbia, 2009)
Tirapazamine (TPZ) is currently undergoing a variety of phase I, II, and III clinical trials for the treatment of various human cancers. TPZ derives its medicinal activity by inducing DNA damage in poorly oxygenated tumor ...
Synthesis and evaluation of 105Rhodium(III) complexes derived from diaminodithioether (DADTE) ligands
(University of Missouri--Columbia, 2006)
Seven analogoues of tetradentate acyclic diaminodithioether (DADTE)ligands were synthesized and characterized. R₂SC(R₁)₂)CHnN(CH₂)mNCHn((R₁)₂C)SR₂ 222-gdm (L3): m = 1, n = 1, R₁ = -CH₃ and R₂ = -H; 222-gdm-pmBz (L4): m = ...
Development of a novel fluorescent sensor for detection of 4-hydroxynonenal
(University of Missouri--Columbia, 2022)
4-Hydroxynonenal (4-HNE) is one of the secondary products of lipid peroxidation and has been studied in the greatest detail, due to its high reactivity and consequently, its role in a wide range of biological processes. ...
LC-MS/MS method development for quantitative analysis of cyanogenic glycosides in elderberry and lipid peroxidation products in mice
(University of Missouri--Columbia, 2021)
Cyanogenic glycosides (CNGs) are naturally occurring plant molecules (nitrogenous plant secondary metabolites) which consist of an aglycone and a sugar moiety. Hydrogen cyanide (HCN) is released from these compounds following ...
Synthesis and preclinical evaluation of peptide receptor-targeted diagnostic and therapeutic radiopharmaceuticals for prostate cancer
(University of Missouri--Columbia, 2019)
The overexpression of certain peptide receptors on cancers cells can be exploited for the development of radiopharmaceuticals that are selectively delivered to cancer cells for diagnostic imaging or therapeutic purposes. ...
Structure and synthesis of four supramolecular structures involving Cu(I) and 4,7-phenanthroline
(University of Missouri--Columbia, 2007)
The design and synthesis of supramolecular species with discrete geometric shapes has been an area of much interest and research in recent years. Three isolated species of square shaped molecules and one infinite network ...
Novel chemical mechanisms of DNA damage by natural products
(University of Missouri--Columbia, 2007)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Leinamycin is a structurally novel natural product isolated from the Streptomyces with potent antitumor and antibiotic activity. In a thiol rich ...
Synthesis and evaluation of modified NOTA chelators labeled with [99mTc]Tc/Re-tricarbonyl cores for potential theranostic agent development
(University of Missouri--Columbia, 2023)
To further optimize [99mTc]Tc/Re-tricarbonyl-NOTA complexes as potential theranostic agents, here we present the synthesis and evaluation of 1,4,7- triazacyclononane (TACN) chelators having different pendant arm functionalities. ...
Nitrosative guanosine deamination : pyrimidine ring opening implications of effects in homogeneous solution as well as anisotropic environments
(University of Missouri--Columbia, 2007)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] In recent years a great deal of interest has been focused on the exposure to nitrous acid (HNO2), nitric oxide (NO) and other nitrosating species ...
Development of advanced chemometric methods for the analysis of deep-UV resonance Raman spectra of proteins
(University of Missouri--Columbia, 2009)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Ultra violet resonance Raman (UVRR) is a powerful spectroscopic technique for determining the secondary structural content of proteins in solution. ...
Evaluation for ammonium bifluoride dissolution for application to post-detonation nuclear forensics and rare Earth element extraction
(University of Missouri--Columbia, 2019)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] If a nuclear device were to be used in an act of terrorism, prompt nuclear forensic analysis of the post-detonation debris is crucial in order to ...
Design and construction of multicomponent spheroidal assemblies on the nano-scale via the self-assembly approach
(University of Missouri--Columbia, 2006)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Supramolecular chemists can be thought of as the architects of the nano-scale world. We are primary concerned with the design and construction of ...
Variable-temperature [superscript 1]H-NMR and AB initio study of 5-amino-imidazole-4-carboxamide (AICA) : competing paths for amide-H scrambling
(University of Missouri--Columbia, 2008)
5(4)-aminoimidazole-4(5)-carboxamide (AICA and TAICA) is an important precursor for the synthesis of purines in general and of the nucleobases adenine and guanine in particular. Biotic nucleobase synthesis has been studied ...
DNA interstrand crosslinks arising from DAN strand breaks at true abasic sites in duplex DNA
(University of Missouri--Columbia, 2018)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Abasic sites (apurinic/apyrimidinic sites, Ap sites) are one of the most common forms of lesions found in genomic DNA. For the past decade, Gates group ...
The preparation of some of the liquid halogen compounds of vanadium and the measurement of their dielectric constants
(University of Missouri--Columbia, 1915)
The present investigation consists of (1) a study of the different methods of preparing the halogen compounds of vanadium and (2) the measurement of the dielectric constant of the three compounds liquid at the ordinary ...
Structure-activity relationship of octreotide analogues labeled with rhenium and technetium-99m
(University of Missouri--Columbia, 2009)
The goal of this research is to cyclize octreotide analogues with ⁹⁹[supersript-m]Tc and ¹⁸⁶/¹⁸⁸Re radiometals to be used as diagnostic and therapeutic agents for neuroendocrine tumors, respectively. Several series of ...