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Now showing items 61-80 of 370
Modeling firing patterns of medium spiny neurons
(University of Missouri--Columbia. Office of Undergraduate Research, 2004)
The alternation in firing patterns of medium spiny neurons of the Nucleus Accumbens , a key structure in the brain's reward pathway, due to chronic and acute cocaine use was investigated through change of ion channel and ...
Do type I collagen defects that cause Osteogenesis Imperfecta result in an inherent muscle pathology? [abstract]
(University of Missouri--Columbia. Office of Undergraduate Research, 2008)
Osteogenesis imperfecta (OI) is a congenital connective tissue disorder characterized by decreased bone mineral density and increased bone fragility and susceptibility to fracture. In addition to skeletal fragility, patients ...
Use of antisense oligonucleotides to enhance exon 7 incorporation in the pre-mRNA splicing of SMN2
(University of Missouri--Columbia. Office of Undergraduate Research, 2004)
Spinal muscular atrophy (SMA) is a neurodegenerative disorder that is relatively common in humans and is caused by loss of the survival motor neuron 1 (SMN1) gene. SMA is the leading cause of hereditary infant mortality ...
A kinetic study of active site mutations in GDP-mannose dehydrogenase
(University of Missouri--Columbia. Office of Undergraduate Research, 2004)
In the human pathogenic bacterium Pseudomonas aeruginosa, GDP-mannose dehydrogenase (GMD) serves as a critical enzyme in the biosynthesis of alginate, a polysaccharide that functions as a protective coating against antibiotics ...
Target test tube assembly process and design for the development of molybdenum-99 [abstract]
(University of Missouri--Columbia. Office of Undergraduate Research, 2008)
Molybdenum-99 (Mo-99) is used to create Tc-99m, a widely used nuclear medicine diagnostic imaging radioisotope. In an attempt to decrease the need for imported Mo-99, development of mechanical systems to efficiently prepare ...
Camgaroo-2 as an indicator of function in embryonic and neuralized stem cells
(University of Missouri--Columbia. Office of Undergraduate Research, 2005)
The transplantation of stem cells to replace cells that have been lost or damaged due to disease or injury is quickly becoming a conceivable treatment method. Embryonic stem (ES) cells have the capacity to become any cell ...
Studying DNA methylation changes of CpG islands in different stages of prostate cancer by pyrosequencing
(University of Missouri--Columbia. Office of Undergraduate Research, 2005)
Prostate cancer is one of the most common forms of cancer in men. Our lab is currently investigating changes in DNA methylation that occur during cancer progression, and in response to the soy phytoestrogen genistein ...
Resource selection of black-footed ferrets based on black-tailed prairie dog distributions
(University of Missouri--Columbia. Office of Undergraduate Research, 2005)
This study investigates how black-footed ferrets (Mustela nigripes) select their habitat in relation to the distribution of black-tailed prairie dogs (Cynomys ludovicianus). Ferrets are one of the rarest and most endangered ...
Making the Cvt pathway/autophagy in vitro
(University of Missouri--Columbia. Office of Undergraduate Research, 2005)
Autophagy, Greek for “self eating”, occurs in all eukaryotic cells to remove damaged or unwanted organelles or to provide a source of nutrients during starvation. In autophagy, a double membrane surrounds a cluster of ...
From pyruvate to PEP...the unknown pathway
(University of Missouri--Columbia. Office of Undergraduate Research, 2004)
Soybean is a major crop in the United States. Its survival and relationship with its environment are closely monitored. For example, we are looking at the symbiotic relationship between soybean and the soil bacteria. These ...
Modeling friction stir welding of Al 2024-T3 [abstract]
(University of Missouri--Columbia. Office of Undergraduate Research, 2007)
Friction stir welding (FSW) is a modification of the traditional friction welding. It is a process patented by The Welding Institute in Cambridge, England in 1991. It is a mechanical process whereby solid-state welding ...
The role of Periostin in regulating the biomechanical properties of cushion tissue
(University of Missouri--Columbia. Office of Undergraduate Research, 2005)
During embryonic heart development the atrio-ventricular (AV) cushions swell and fuse to form the valves and septa of the adult heart. Initially, the cushions appear as swellings on the interior wall of the AV canal and ...
Molecular free volume and viscosity changes in non-Newtonian fluids probed with molecular rotors
(University of Missouri--Columbia. Office of Undergraduate Research, 2005)
An empirical relationship between molecular free volume and viscosity has been established (Doolittle AK, J Appl. Phys. 1952; 23: 236-9). Non-Newtonian fluids hold much importance to scientific study because of their ...
Issues with scale using very high resolution digital aerial photographs
(University of Missouri--Columbia. Office of Undergraduate Research, 2005)
This study involves the use of remote sensing equipment to observe plant communities. A remote sensor is any instrument that gathers information about an object or area from a distance. Advanced cameras, the most common ...
MCP-1 and its role in lyme arthritis [abstract]
(University of Missouri--Columbia. Office of Undergraduate Research, 2008)
Lyme disease is caused by infection with the bacteria Borrelia burgdorferi, causing arthritis and carditis in infected animal models. The presence of spirochetes in the joint and other soft tissues induce recruitment of ...
Efficacy of modified constraint-induced movement therapy (mCIMT) protocol with clients with chronic stroke [abstract]
(University of Missouri--Columbia. Office of Undergraduate Research, 2008)
Objective: To determine efficacy of a new modified constraint - induced movement therapy protocol in clients with chronic stroke. Method: Each participant will undergo a six week modified constraint-induced movement (mCIMT) ...
Natural variation in phenotypes associated with phototropins among geographically isolated populations of Arabidopsis thaliana [abstract]
(University of Missouri--Columbia. Office of Undergraduate Research, 2008)
In Arabidopsis thaliana several phenotypes are controlled by blue light including chloroplast relocation movements and bending of the seedling stem in phototropism. These responses are controlled by the phototropins, phot1 ...
Electrohydrodynamic conduction pump - An experimental investigation [abstract]
(University of Missouri--Columbia. Office of Undergraduate Research, 2008)
Electrohydrodynamic pumps (EHD) were built and tested to further understand the nature of the technology. Two pumps built used a conductive pumping action to achieve flow within a dielectric fluid. The first pump (pump 11) ...
Identification of chloroplast DNA insertions in nuclear chromosomes of maize B73 line using the FISH procedure
(University of Missouri--Columbia. Office of Undergraduate Research, 2005)
It is known that chloroplast DNA can incorporate itself into the nuclear genome of plants. However, the sites of chloroplast (ct) DNA integration into chromosomes of maize have not yet been analyzed. This project is the ...
The effects of oncogenic Ras on the ocular lens
(University of Missouri--Columbia. Office of Undergraduate Research, 2004)
Ras is a small GTP-binding protein in the signal transduction machinery. In most cell types, activation of Ras by growth factors is essential for normal cell proliferation. A mutation in the Ras gene can lead to a constitutive ...