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Now showing items 61-80 of 661
Evaluation of micro-dystrophin based and dystrophin-independent AAV gene therapies for Duchenne Muscular Dystrophy
(University of Missouri--Columbia, 2020)
the impact of hinge 1 (H1) and hinge 4 (H4) regions in the function of a micro-dystrophin ([micro]Dys) construct. Two novel micro-dystrophins were engineered by complete deletion of either hinge 1 or hinge 4 and packaged in AAV9. Three separate groups of 3...
Influence of site conditions on near-field effects in multi-channel surface wave measurements
(University of Missouri--Columbia, 2011)
Geophysical measurements using surface wave methods (SWM) are in widespread use as a means to non-destructively and non-intrusively characterize geotechnical site conditions for a variety of applications. Surface wave ...
Adaptive array signal processing using the concentric ring array and the spherical array
(University of Missouri--Columbia, 2009)
This thesis introduces new methods for partial adaptive beamforming using concentric ring and spherical arrays for acoustic signals on a partially known interference environment. We propose novel methods to choose intra-ring ...
Nonlinear mechanics and testing of highly flexible one-dimensional structures using a camera-based motion analysis system
(University of Missouri--Columbia, 2006)
Both experimental and theoretical investigations are conducted for the dynamics of cables and strings. The exact equations of motion for finite but small amplitude vibration of string were derived based on a fully nonlinear ...
Regulation of early trophoblast differentiation and development
(University of Missouri--Columbia, 2010)
have used immunohistochemical staining for specific pluripotent markers Oct-4 and SSEA 3 and differentiation marker SSEA 1 to assess the effect of low oxygen tension on the development of hES cells. We observed that low O[subscript 2] tension prevents...
The Spoon Toe Site (11MG179): Middle Woodland gardening in the lower Illinois River Valley
(University of Missouri--Columbia, 2005)
This thesis is an examination of archaeobotanical remains from the Spoon Toe site, a Middle Woodland Massey phase site located in the uplands above the Lower Illinois River valley in Morgan County in western Illinois. The ...
Anion and solvent influences on the self-assembly of copper(I) coordination solids
(University of Missouri--Columbia, 2005)
and the reaction conditions involved will be discussed. This presentation will be divided into four major sections. The first section covers an in-depth look at those structural variances found among the copper(I) coordination solids synthesized using 4,4...
Assessment of Seismic Hazards along the Northern Gulf of Aqaba
(2014-09-26)
Aqaba and Elat are very important port and recreation cities for the Hashemite Kingdom of Jordan and Israel, respectively. The two cities are the most susceptible to damage from a destructive future earthquake because they ...
Radionuclide production and separation techniques for radiopharmaceutical development and nuclear waste processing
(University of Missouri--Columbia, 2018)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] With increasing cancer incident rates and advancements in nuclear medicine, the demand for optimizing pathways to produce radionuclides or investigating ...
Oxidative DNA damage by 1-hydroxyphenazine, virulence factor of Pseudomonas aeruginosa : towards a molecular understanding of the bacterial virulence factor 1-hydroxyphenazine
(University of Missouri--Columbia, 2008)
1-Hydroxyphenazine is a secondary metabolite and virulence factor of Pseudomonas aeruginosa. This organism colonizes the airways of the patients of cystic fibrosis and causes progressive destruction of the airways. It is ...
Evaluation of Resistivity Meters for Concrete Quality Assurance, Project TR201414
(2015-07-28)
This research evaluated a series of MoDOT concrete mixtures to verify existing
relationships between surface resistivity (SR), rapid chloride permeability (RCP), chloride ion
diffusion, and the AASHTO penetrability ...
Quasi-metric geometry : smoothness and convergence results
(University of Missouri--Columbia, 2011)
This thesis has two distinct yet related parts, the first pertaining to geometry on quasi-metric spaces with emphasis on the Hausdorff outer-measure, the natural extension of the Gromov-Pompeiu-Hausdorff distance to ...
A fast, 3 MV Marx generator for megavolt oil switch testing and integrated Abramyan network design
(University of Missouri--Columbia, 2005)
The University of Missouri-Columbia has a new test facility online to study oil breakdown of enhanced and uniform gaps. The 3 megavolt Marx generator is operational with switch configurations tested including large electrode ...
Evaluating alginate and organic acids for restructured carp intended for zoo animal and human diets
(University of Missouri--Columbia, 2008)
were analyzed for texture, pH and water holding capacity by using standard methods. Statistical results showed that the texture of all the treatments are significantly different (P [less than] 0.05) from the control. Treatment T3 had significantly low pH...
Synthesis, self-assembly and applications of tribenzopenta-phene derivatives and triphenylene-based conjugated foldamers
(2013)
Polycyclic aromatic hydrocarbons (PAHs) are interesting discotic liquid crystalline materials. Their often planar or near-planar geometry and extended π-delocalization render them appealing π-π stacking building blocks ...
Drug resistance in D. discoideum: isolation of 4-nitroquinoline 1-oxide resistant mutants
(University of Missouri--Columbia, 2005)
The drug 4-nitroquinoline 1-oxide (4NQO) displays both carcinogenic and antitumor effects, a well known characteristic of many chemotherapeutic drugs. In addition 4NQO shares a similar operating mechanism with the commonly used chemotherapeutic drug...
Land cover classification from satellite imagery, and its applications in cellular network planning
(University of Missouri--Columbia, 2005)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] To further increase the classification accuracies, radar image processing techniques were investigated to preprocess the Radarsat data before classification. ...
Biomineralizers from the proterozoic to today : assessing taxonomy and paleoecology through the lens of taphonomy
(University of Missouri--Columbia, 2018)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The onset of metazoan predation is presumed to have triggered an evolutionary arms race of prey defenses, including the advent of biomineralization. ...
Fuel depletion analyses at the Missouri University Research Reactor
(University of Missouri--Columbia, 2006)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] In developing, assembling and updating safety analysis cases for nuclear power and research reactors, fuel depletion plays a major role and ultimately ...
Mechanisms of inhibition and resistance to antiviral drugs targeting human immunodeficiency virus type 1 (HIV-1) and hepatitis B virus (HBV)
(University of Missouri--Columbia, 2012)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Although human immunodeficiency virus type 1 (HIV-1) and hepatitis B virus (HBV) are very different viruses, the replication of their genome involves ...