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Investigating the role of a lncRNA (4833427F10Rik) in mouse placental development and function
(University of Missouri--Columbia, 2022)
differentially expressed between the embryonic and extraembryonic tissues of E7.5 mouse conceptus. Specifically, a candidate lncRNA 4833427F10Rik had expression specific to the placental lineages in conceptus during early development stage. Both RT...
Quantitative biological studies at cellular and sub-cellular level
(University of Missouri--Columbia, 2007)
We developed a translational magnetic tweezers for quantitative measurements at cellular and sub-cellular level. In the cellular studies, multiple membrane tethers were extracted simultaneously under constant force transduced ...
Assessing the occurrence of cyanotoxins in two urban reservoirs through a community science monitoring program
(University of Missouri--Columbia, 2021)
Cyanobacterial blooms are an ongoing threat to aquatic systems worldwide. These potentially toxic blooms have typically been observed in summer to early fall, but there are increasing reports of blooms in colder seasons. ...
Characterization of the sporozoite and eythrocytic stages (SES) protein
(University of Missouri--Columbia, 2007)
The Plasmodium sporozoite is infective for mosquito salivary glands and vertebrate host tissues. Although it is a key developmental stage of the malaria parasite, relatively few sporozoite surface or secreted proteins have ...
The effects of 6-weeks of resistance training on the gut microbiome in young adults with overweight and obesity
(University of Missouri--Columbia, 2022)
INTRODUCTION: Obesity is a known risk factor for the development of insulin resistance, type 2 diabetes, and other cardiometabolic outcomes. Recently, the gut microbiome had been identified as a possible contributor to the ...
Polynomial system identification modeling and adaptive model predictive control of arterial oxygen saturation in premature infants
(University of Missouri--Columbia, 2020)
The automation of the regulation of the fraction of inspired oxygen (FiO2) in neonatal mechanical ventilation to treat respiratory distress syndrome has proven challenging due to competing objectives: maintaining arterial ...
Factors affecting the growth of dairy animals
(University of Missouri--Columbia, 1916)
Text from introduction: All successful breeders are continually striving to improve the quality of their herds. The value of any dairy herd is determined to a great extent by the way in which the heifers within that herd ...
Applying deep learning technologies to discovery and characterization of genetic variants in animal genomes
(University of Missouri--Columbia, 2023)
[EMBARGOED UNTIL 12/1/2024] The scale of publicly available genomic data has rapidly expanded by an order of magnitude within the last decade. However, research with these aggregated public data requires minimizing the ...
Power efficient machine learning-based hardware architectures for biomedical applications
(University of Missouri--Columbia, 2023)
The future of critical health diagnosis will involve intelligent and smart devices that are low-cost, wearable, and lightweight, requiring low-power, energy-efficient hardware platforms. Various machine learning models, ...
Understanding the effects of maternal undernutrition in early gestation on placental development in late gestation
(University of Missouri--Columbia, 2018)
Chronic diseases such as cardiovascular disease and diabetes are on the rise among the U.S. population. Heart Disease is the leading cause of death in the US and is responsible 610,000 deaths per year. A suite of risk ...
Evolution, transmission, and clinical impacts of SARS-CoV-2 and influenza viruses
(University of Missouri--Columbia, 2023)
[EMBARGOED UNTIL 12/1/2024] Influenza and coronaviruses are leading causes of human respiratory diseases, causing substantial global impact. The ongoing evolution of SARS-CoV-2 and influenza viruses continues to trigger ...
Novel biomaterials for controlled immunomodulatory drug delivery
(University of Missouri--Columbia, 2022)
With the success of solid organ transplantation, a next generation approach has been developed known as vascularized composite allografts which requires the transplantation of a whole functional unit comprised of many ...
DLC1 as a comparative epigenetic biomarker for radiotherapy of Non-Hodgkin's lymphoma
(University of Missouri--Columbia, 2007)
The American Cancer Society estimates that 58,870 people were diagnosed with non-Hodgkin's lymphoma (NHL) in 2006, and 18,840 people died of the disease. Recent investigation of epigenetic gene regulation has identified ...
Examination of metabolic and regulatory networks of desulfovibrio species
(University of Missouri--Columbia, 2004)
integrity. A computational analysis of the promoter regions of putative transcription units of Desulfovibrio revealed possible regulatory protein binding motifs homologous to the E. coli CRP and GalR binding sites as well as a motif common to genes encoding...
Identification of Novel Regulatory Genes in Acetaminophen Induced Hepatocyte Toxicity by a Genome-Wide CRISPR/Cas9 Screen
(University of Missouri -- Kansas City, 2018)
Acetaminophen (APAP) is a commonly used analgesic responsible for over 56,000
overdose-related emergency room visits annually. A long asymptomatic period and limited
treatment options result in a high rate of liver ...
Development of Advanced Delivery Systems for Microbicides
(2016)
HIV/AIDS still continues to be a pandemic and global emergency and is a leading cause of
death among the women of reproductive age (15-49 yr). Women are more vulnerable for HIV infection
due to anatomical and physiological ...
The teaching of handwriting
(University of Missouri--Columbia, 1917)
Text from page 1: The problem of this investigation is to study the uses of diagnosis and corrective measures in the teaching of handwriting.
Developmental programming by xenoestrogens
(University of Missouri--Columbia, 2011)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Xenoestrogens (XE) are chemicals in the environment that mimic the body's natural steroidal estrogens. Developmental exposure to XE may interfere with ...
An analysis of aspartic peptidases expressed by trophoblasts and placenta of even-toed ungulates
(University of Missouri--Columbia, 2008)
The Pregnancy Associated Glycoproteins (PAGs) represent a multigene family of trophoblast expressed proteins, found exclusively in the placenta of even-toed mammals such as ruminants (cattle, sheep), pig, etc. In ruminants, ...
Investigating the deleterious role of B lymphocytes during brucella infection
(University of Missouri--Columbia, 2020)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI--COLUMBIA AT REQUEST OF AUTHOR.] Brucellosis is a disease known for inducing chronic, often life-long, infections. While it is clear the host immune response fails to clear ...