Search
Now showing items 81-100 of 1483
Use of antisense oligonucleotides to enhance exon 7 incorporation in the pre-mRNA splicing of SMN2
(University of Missouri--Columbia. Office of Undergraduate Research, 2004)
Spinal muscular atrophy (SMA) is a neurodegenerative disorder that is relatively common in humans and is caused by loss of the survival motor neuron 1 (SMN1) gene. SMA is the leading cause of hereditary infant mortality ...
Effects of culture conditions on cytosine methylation and MeCP2 binding in preimplantation mouse embryos
(University of Missouri--Columbia. Office of Undergraduate Research, 2008)
Imprinting is an epigenetic modification in which one gene of a pair of alleles is silenced in a parent-specific way. Imprinting is commonly controlled by methylation of the C5 position of cytosines which are located next ...
A kinetic study of active site mutations in GDP-mannose dehydrogenase
(University of Missouri--Columbia. Office of Undergraduate Research, 2004)
In the human pathogenic bacterium Pseudomonas aeruginosa, GDP-mannose dehydrogenase (GMD) serves as a critical enzyme in the biosynthesis of alginate, a polysaccharide that functions as a protective coating against antibiotics ...
Target test tube assembly process and design for the development of molybdenum-99 [abstract]
(University of Missouri--Columbia. Office of Undergraduate Research, 2008)
Molybdenum-99 (Mo-99) is used to create Tc-99m, a widely used nuclear medicine diagnostic imaging radioisotope. In an attempt to decrease the need for imported Mo-99, development of mechanical systems to efficiently prepare ...
Juvenile salamander dispersal and use of terrestrial microhabitat cues
(University of Missouri--Columbia. Office of Undergraduate Research, 2008)
The effects of deforestation are profound on amphibian populations. In order to balance land use practices with amphibian conservation, biologists and land managers must understand the habitat requirements of amphibians ...
Efficacy of turmeric (Curcuma longa) to ameliorate the adverse effects of T-2 toxin in broiler chicks
(University of Missouri--Columbia. Office of Undergraduate Research, 2008)
A 3-wk feeding study was conducted to evaluate the efficacy of turmeric (Curcuma longa) powder (TMP), containing a known level of curcumin to ameliorate the adverse effects of T-2 toxin in broiler chicks. Five pen replicates ...
Fragment based screens of the -D-phosphohexomutases as an initial step for inhibitor design
(University of Missouri--Columbia. Office of Undergraduate Research, 2008)
Enzymes in the -D-phosphohexomutases superfamily frequently play a role in the biosynthesis of carbohydrates and glycolipids, critical for bacterial virulence and growth. -D-phosphohexomutases are being increasingly shown ...
Variation in mushroom frequency on course-woody debris in areas of different forest management techniques
(University of Missouri--Columbia. Office of Undergraduate Research, 2008)
Different forest management techniques may have serious varying ecological consequences. Our focus was on the mushrooming bodies of fungus on course-woody debris in three differently managed areas of forest. This is an ...
Analyzing the effects of lactose on calcium absorption in premature infants using HR-ICP-Mass Spectrometry
(University of Missouri--Columbia. Office of Undergraduate Research, 2005)
With advances in neonatal care, premature infants are surviving at increasing rates. During the third trimester of pregnancy, the bone mineral content of infants rapidly increases. It is therefore becoming essential to ...
The effects of sensitization on habituation using the olfactory jump reflex in Drosophila
(University of Missouri--Columbia. Office of Undergraduate Research, 2004)
Memories can arise from simpler habituation and sensitization training as well as associative classical conditioning. However, in a complex environment, animals receive sensory cues in a fashion that can be more accurately ...
Expression of a putative virulence protein of Haemophilus influenzae in E. coli
(University of Missouri--Columbia. Office of Undergraduate Research, 2004)
Haemophilus influenzae, a small, gram-negative bacterium, is a commensal organism of the human upper respiratory system as well as an agent of diseases ranging from otitis media to meningitis. Nonencapsulated (nontypeable, ...
The correlation between Chicano theater and Augusto Boal's Theater of the Oppressed
(University of Missouri--Columbia. Office of Undergraduate Research, 2004)
"The theater is a weapon, and it is the people who should wield it" are words that come from the Brazilian Dramatist's, Augusto Boal, commentary, The Theater of the Oppressed. What Boal is referring to is that the theater ...
Rapid automated characterization of transposon insertion mutants in Desulfovibrio vulgaris Hildenborough by srnPCR [abstract]
(University of Missouri--Columbia. Office of Undergraduate Research, 2008)
Tn5 transposon mutagenesis occurs by a mechanism in which a segment of DNA (transposon) encoded in a plasmid is inserted into genomic DNA (the target) by a conservative (cut-and-paste) mechanism (Fig. 2). When the insertion ...
Photoacoustic detection of circulating melanoma cells in the plasma layer of the blood [abstract]
(University of Missouri--Columbia. Office of Undergraduate Research, 2008)
When a melanoma patient is diagnosed, aggressive treatment is advised in an effort to contain the disease. Although the initial malignant cells are destroyed, it is impossible to determine whether or not the cancer has ...
Impact of prior/concurrent exposure to infectious diseases on variability in the 1918-19 flu epidemic on Newfoundland [abstract]
(University of Missouri--Columbia. Office of Undergraduate Research, 2008)
Between 1918 and 1920 nearly 2000 people on the island of Newfoundland died from influenza, pneumonia, and related illnesses. Deaths were recorded from all parts of the island, but there is substantial regional variability ...
Natural variation in Arabidopsis thaliana: Molecular genetic architecture of stress tolerance under water deficit
(University of Missouri--Columbia. Office of Undergraduate Research, 2004)
The functional genomics tools available for studying Arabidopsis thaliana are a great resource for researchers trying to characterize and understand the genetic basis of natural variation. Genome wide transcript profiling ...
Uranium: The problem, or the solution?
(University of Missouri--Columbia. Office of Undergraduate Research, 2004)
Uranium is of great importance as a nuclear fuel and is used to generate electrical power, produce isotopes, and to make weapons. The possibility of developing a realistic flow scheme for nuclear fuel reprocessing or ...
Expression and purification of AlgX in Pseudomonas aeruginosa
(University of Missouri--Columbia. Office of Undergraduate Research, 2005)
Pseudomonas aeruginosa is a Gram-negative bacterium that is the leading cause of hospital acquired infections. While this bacteria is present in water and soil, this bacteria only severely affects severely ill patients, ...
Characterizing polymerization dynamics using fluorescent molecular rotors and magnetoelastic sensors
(University of Missouri--Columbia. Office of Undergraduate Research, 2005)
The dynamics of polymerization are critical in many medical applications; for instance, polymers used to fill aneurysms must be timed accurately. Two distinct methods were examined for their ability to probe the polymerization ...
Aβ toxicity to SHSY-5Y human neuroblastoma cells
(University of Missouri--Columbia. Office of Undergraduate Research, 2005)
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that results in the loss of memory, language deterioration, confusion, restlessness, and eventually destroyed cognition. It is characterized by an ...