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Now showing items 101-120 of 120
Peptide nanoconjugates for tissue diagnostics and molecular imaging
(University of Missouri--Columbia, 2016)
The rise of targeted therapy in cancer treatment has created a strong need for characterization of a patient's tumor before receiving treatment. Many effective cancer drugs are now being targeted to specific proteins present ...
Rapid detection and characterization of mycobacteria using microchannel electrical impedance spectroscopy
(University of Missouri--Columbia, 2017)
The presence of virulent, pathogenic bacteria in our body, food, water and other consumables is harmful and causes enormous economic and personal losses. Here we will be looking at developing a platform technology that can ...
The role of Pre-B-cell colony-enhancing factor in neuronal death after ischemia and motor dysfunction
(University of Missouri--Columbia, 2016)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Pre-B-cell colony-enhancing factor (PBEF) is the rate-limiting enzyme in the salvage pathway of mammalian nicotinamide adenine dinucleotide (NAD+) ...
Knee contact force prediction during a step-up task using a subject specific musculoskeletal model with anatomical knee
(University of Missouri--Columbia, 2018)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Better understanding of knee mechanics can aid in injury prevention and rehabilitation. Multi-body computational models can be used to better understand ...
Investigation of supercritical water processing of biomass : study of high pressure separation
(University of Missouri--Columbia, 2016)
Global warming is caused by greenhouse gases such as CO2, CH4, NOx, and SOx. CO2 makes up about 80% (by mass) of greenhouse gas emitted by human activities. Therefore, CO2 emission plays a significant role in global warming. ...
Evaluating removal of nutrients, volatile organic compounds, and nicotine by bioretention soil mixtures with biochar amendment
(University of Missouri--Columbia, 2016)
Urbanization results in reduced infiltration contributing to potential urban flooding and stormwater contaminants. Urban stormwater pollutants, including total suspended solids (TSS), nutrients, heavy metals, oil and grease ...
Design and characterization of a hand-held, waveguide-mediated, optoacoustic imaging probe for analyzing burn wounds
(University of Missouri--Columbia, 2018)
Clinicians correctly diagnose only [about]66% of burn wounds, which may be in part due to the qualitative methods commonly employed for burn assessment. This often results in over diagnoses, which may lead to unnecessary ...
Single nucleotide polymorphism (SNP) discriminations by nanopore sensing
(University of Missouri--Columbia, 2018)
Single Nucleotide Polymorphisms (SNPs) are a common type of nucleotide alterations across the genome. A rapid but accurate detection of individual or SNP panels can lead to the right and in-time treatments which possibly ...
In situ polymerizing collagen for the development of 3D printed tissue engineering scaffolds
(University of Missouri--Columbia, 2018)
Natural materials have been processed and utilized as scaffold materials in the field of tissue engineering for many years. One natural material often utilized is collagen since it is the main structural protein in mammalian ...
Between-row mower design for weed control in organically grown no-till soybeans
(University of Missouri--Columbia, 2018)
Weeds are a major challenge in organic no-till soybean production. They impair crop growth and result in yield loss. Innovative weed control methods need to be developed and experimented with in organic no-till agriculture ...
Evaluation of a solid-liquid manure separation operation
(University of Missouri--Columbia, 2018)
Field monitoring and laboratory tests were conducted to evaluate the efficacy and practicality of a solid-liquid separation barn for finishing pigs. The solid-liquid separation system included a mechanical scraper and ...
Design and synthesis of targeted NIR fluorescent nanoparticles for bio-imaging
(University of Missouri--Columbia, 2019)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI--COLUMBIA AT REQUEST OF AUTHOR.] Breast cancer is the second most common cancer, and the chance that a woman will die from breast cancer is 2.6%. One in 8 women develop ...
Automated detection of amperometric spikes resulting from quantal exocytosis and estimation of spike and pre-spike foot signal parameters
(University of Missouri--Columbia, 2018)
Electrochemical microelectrodes can detect single-vesicle release events as "spikes" of amperometric current. We developed a template based "matched-filter" approach that performs least squares fit of a library of templates ...
Direct from sample phenotypic antibiotic susceptibility testing
(University of Missouri--Columbia, 2018)
To transition from broad-spectrum antibiotic therapy to a more effective "targeted" therapy, i.e. in order to determine whether the infecting strain is resistant or susceptible to individual candidate antibiotics, clinicians ...
The design of fluorescence correlation spectroscopy for single molecule techniques
(University of Missouri--Columbia, 2019)
The ribosome is responsible for protein synthesis--a critical process in creating essential proteins for cell survival. Though bulk techniques yield valuable results about the structure of the ribosome, bulk techniques are ...
Climate and land use effects on hydrologic processes and water allocation in a primarily rain-fed, agricultural watershed
(University of Missouri--Columbia, 2018)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] There is a need to raise our understanding of the impact of climate variability and change on hydrologic processes at the watershed scale. This is ...
Green solvent-enabled biomass conversion for renewable chemicals and lignin upgrading
(University of Missouri--Columbia, 2018)
Lignocellulosic biomass, which is mainly composed of cellulose, hemicellulose, and lignin, is a promising feedstock for producing renewable chemicals and fuels. To make lignocellulosic biomass-based refinery (biorefinery) ...
Direct-from-sputum rapid phenotypic drug susceptibility test for mycobacteria
(University of Missouri--Columbia, 2018)
The spread of multi-drug resistant tuberculosis (MDR-TB) is a leading global public-health challenge. Because not all biological-mechanisms of resistance are known, culture-based (phenotypic) drug-susceptibility testing ...
Four-limb IMU sensors for canine gait analysis
(University of Missouri--Columbia, 2019)
Canine models of human musculoskeletal diseases, such as Duchenne muscular dystrophy (DMD), are important translational animal models for developing therapies. Musculoskeletal diseases alter gait performance, and gait ...
Methods of imaging articular cartilage under shear
(University of Missouri--Columbia, 2019)
Characterizing both the structure of articular cartilage, and its biomechanical properties is key to gaining a full understanding of how the tissue functions. Articular cartilage is an inhomogeneous tissue with a depth ...