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Trends in the Prevalence of Acute Kidney Injury in Patients with Acute Myocardial Infarction
(2010-03)
Introduction: Acute kidney injury (AKI) is common in patients (pts) with acute myocardial infarction (AMI), and associated with permanent renal impairment and death. While guidelines increasingly emphasize the importance ...
Unprecedented protection of the retina from glaucoma-induced nerve damage by topical administration of a novel prodrug
(2010-03)
The preclinical development of a prodrug-based site-specific delivery strategy that allows for targeting a potent small-molecule neuroprotectant into the eye, and with preference to the retina, after topical administration ...
Effects of Isoflurane on Plasma-Membrane Calcium ATPase
(2010-03)
Introduction: Plasma membrane Ca2+-ATPase (PMCA) is a transmembrane enzymatic protein present in human neurons, myocytes, and RBCs which plays a role in controlling cellular Ca2+ levels by regulating intracellular ATP. ...
Prevalence, Correlates, and Inter-hospital Variation of Early Outpatient Follow-up After Acute Myocardial Infarction
(2010-03)
Background: Early outpatient follow-up (EFU) after acute myocardial infarction (AMI) is strongly endorsed in guidelines and has been emphasized nationally as a means to improve transitions of care, medication adherence ...
Development of a Capillary Blood Mail-in Kit for the Measurement of Hemoglobin A1c
(2010-03)
It is estimated that in the United States diabetes affects 25 million children and adults, and is a major cause of morbidity and mortality. Cost of diabetes in the United States is over $175 billion a year. To optimize ...
Impact of Clopidogrel Pretreatment on Ischemic Complications of PCI among Bivalirudin-Treated Patients: Results from the EVENT Registry
(2010-03)
Background: Although clopidogrel (CLO) pretreatment benefits PCI patients with acute coronary syndromes, these benefits are less well-established among elective PCI patients—particularly when treated with the direct thrombin ...
Walk A Hound, Lose A Pound, & Stay Fit for Seniors
(2010)
Background: Obesity rates in older adults are linked with the national problem of limited physical activity (PA), resulting in chronic illness. Obesity-related illness and functional loss require innovative interventions. ...
Isolation of modulators of Organic Anion Transporting Polypeptides (OATPs) from Rollinia emarginata Schlecht (Annonaceae)
(2010-03)
Organic Anion Transporting Polypeptides (OATPs) comprise a superfamily of sodium-independent membrane transporters which are involved in transporting numerous endogenous and exogenous substances. OATPs are expressed in ...
Porcine induced pluripotent stem cells (piPSC) for expanding the use of swine in biomedical research
(2010-03)
for exploiting the pig as a model in human pre-clinical applications. Supported by Missouri Life Sciences Board Grant 00022147 and NIH grant HD21896...
Translational Approach to Examine the Importance of Aerobic Fitness on Nonalcoholic Fatty Liver Disease [abstract]
(2010)
) with significantly lower aerobic fitness (Science, 307:418-20, 2005). These rats display contrasting phenotypes without the influence of exercise training, making them an excellent model to mechanistically assess the role of aerobic fitness on NAFLD. Utilizing...
Swab Test Using ELISA Technique for Diagnosis of Brown Recluse Bites
(2010-03)
Envenomations by the brown recluse spider, Loxosceles reclusa, are a significant source of morbidity and occasional mortality in endemic regions of the United States, and misdiagnoses are common. A survey of physicians in the endemic area has shown...
Extension of previous fusions to the Sacro-Pelvis vs. Primary spino-pelvic fusions in the setting of adult deformity: A Comparison of health related quality of life measures and complications [abstract]
(2010)
Summary: Clinical and radiographic evaluation of revision extension of previous long thoracolumbar fusion to the sacro-pelvis compared to primary lumbosacral fusion indicates that although the two patient populations are ...
Cloning & Transgenic Swine for Medical and Agricultural Uses at MU
(2010-03)
important that it has helped establish the National Swine Resource and Research Center at the University of Missouri to serve as a genetic resource for the biomedical community....
Investigation and Optimization of Silorane-Based Polymer System [abstract]
(2010-03)
This research is a collaboration between Department of Oral Biology in the School of Dentistry at UMKC, Department of Chemistry in The College of Arts and Sciences at UMKC, Department of Chemistry at Missouri Science and Technology, and Mo...
Make It Your Own Clinical Trials Posters: A Regional Collaboration with the National Cancer Institute
(2010-03)
Introduction: National health organizations usually offer a limited variety of publication resources to the regional organizations that they serve. These resources may not always reflect the needs of the populations served in those diverse areas...
Synaptic dysfunction in migraine: novel approaches for drug development [abstract]
(2010)
Migraine is a severe paroxysmal neurovascular disorder, affecting up to 16% of the Western population. Current migraine drugs are largely targeted towards the pain associated with the migraine headache, and their efficacy ...
INFORMER and Potassium Values: A system to enhance detection, notification, and action upon a threat to patient safety in the emergency department [abstract]
(2010)
Background: Quick remediation should occur after critically abnormal potassium levels are detected by the medical laboratory in blood from emergency department (ED) patients. Critical potassium levels can be elevated ...
A Collaborative Platform for Sharing EHRs of Cancer Patients [abstract]
(2010)
Today the nation faces one of the toughest challenges in health care due to high operating costs. By 2017, it is projected that the nation would spend $4.3 trillion for health care. One way to lower health care costs and ...
A Single Antibody based ELISA for the N-terminal sequence of BAG-75, a New Biomarker for Bone Formation [abstract]
(2010)
Bone acidic glycoprotein-75 (BAG-75) is a secreted product of osteoblastic cells localized predominantly to areas of new bone formation. We have identified the N-terminal sequence of BAG-75 as LPVARYQNTEEEE and shown that ...
Classification of Body Motions Based on Posturographic Data [abstract]
(2010)
Introduction: The human body, while standing, can be modeled as an unstable feedback system. This produces a continuous sway pattern, which manifests itself as varying ground reactions that are measured with force plates ...