2014 UMKC Dissertations - Freely Available OnlineThe items in this collection are the scholarly output of UMKC graduate students.https://hdl.handle.net/10355/432572024-03-19T01:24:52Z2024-03-19T01:24:52Z364 Days: Suite for Jazz OrchestraChapman, Jonathan Erichttps://hdl.handle.net/10355/495362019-05-20T18:47:46Z2014-01-01T00:00:00Z364 Days: Suite for Jazz Orchestra
Chapman, Jonathan Eric
364 Days: Suite for Jazz Orchestra was composed for a standard seventeen-piece (5/4/4/4) jazz orchestra. The suite is comprised of five pieces- And I Think of You; Goodnight; What Ifs; 364 Days; The Dreamer and The Realist - and were recorded for the album J.E. Chapman, 364 Days: music for large ensembles. Each movement of the suite is intended to work as a part of the larger work or out of context as an individual performance piece. The sections of the suite are connected through an "affiliated motif". Each piece is tied together through intervallic commonalities, common melodic contour, and "spirit" but are unique enough in their own individuality to posses their own personality. While the intent is for the suite to be performed as a complete work I took great effort in creating five works that could be performed separately and yet still sound complete; each piece has its own unique formal structure and distinctive rhythmic and style elements that allow them to succeed as part of a set or as an isolated work. These compositions blend modern jazz harmonies and non-traditional formal structures; staying connected to and extending the tradition of jazz composition.
Title from PDF of title page, viewed on July 15, 2016; Dissertation advisor: Reynold Simpson; Vita; Thesis (D.M.A.)--Conservatory of Music and Dance, University of Missouri--Kansas City, 2016
2014-01-01T00:00:00ZAnalyzing the effects of Cis-elements and trans-factors on the stability of the Gal1 mRNPPirani, Karimhttps://hdl.handle.net/10355/456122019-05-31T16:08:08Z2014-01-01T00:00:00ZAnalyzing the effects of Cis-elements and trans-factors on the stability of the Gal1 mRNP
Pirani, Karim
The highly dynamic and nonrandom spatial organization of the eukaryotic nucleus plays an important role in the regulation of gene expression. For example, in S. cerevisiae, several conditionally expressed genes relocate to the nuclear periphery upon activation. Moreover, these genes can be retained at the nuclear periphery for a considerable time after transcriptional shutoff. Sequence specific DNA binding proteins, transcription, chromatin remodeling, and mRNP quality control factors have all been implicated in perinuclear gene repositioning, but their relative contributions to the events of gene recruitment, capture and retention at the periphery remain unresolved. Sus1 is a conserved eukaryotic protein involved in transcription, mRNA export and perinuclear gene repositioning. Here, we show that the functions of Sus1p in perinuclear repositioning of GAL genes and its chromatin-linked functions can be genetically uncoupled, and that the role of Sus1p in the retention of mRNA in gene-proximal foci is chromatin-independent. Histone variant H2A.Z, likewise has been suggested to play a role in the post-transcriptional association of the yeast genes with the nuclear periphery. Our findings indicate that the loss of H2A.Z doesn’t alter gene-proximal mRNA retention, but has a differential effect on perinuclear repositioning of GAL genes.
H2A.Z affects recruitment of GAL1 promoter-driven genes to the nuclear periphery in a 3’UTR-dependent manner, but its effect on posttranscriptional retention of GAL1 genes at the nuclear periphery is locus specific. Our previous analysis has also shown that the retention of RNA at the site of transcription is dependent on 3’end of the Gal1. Our results indicate that the absence of AU-rich element (ARE) sequence in Gal1 3’UTR may be one of the factor leading to Gal1 mRNP formation at the transcription site. Moreover, our data shows that by introducing the ARE sequence (TATTTAT), between the two cleavage sites of Gal1 3’UTR, it not only reduces the number of cells that for Gal1 mRNP but also abolishes the synthesis of extended transcript at Gal1 locus.
Title from PDF of title page, viewed on June 8, 2015; Dissertation advisor: Michael O’Connor; Vita; Includes bibliographic references (pages 90-102); Thesis (Ph.D.)--School of Biological Sciences. University of Missouri--Kansas City, 2014
2014-01-01T00:00:00ZBayesian Change Point Analysis of Copy Number Variants
Using Human Next Generation Sequencing DataMeng, Jianfenghttps://hdl.handle.net/10355/456112019-05-31T16:15:34Z2014-01-01T00:00:00ZBayesian Change Point Analysis of Copy Number Variants
Using Human Next Generation Sequencing Data
Meng, Jianfeng
Read count analysis is the principal strategy implemented in detection of copy number variants using human next generation sequencing (NGS) data. Read count data
from NGS has been demonstrated to follow non homogeneous Poisson distributions.
The current change point analysis methods for detection of copy number variants are
based on normal distribution assumption and used ordinary normal approximation in
their algorithms. To improve sensitivity and reduce false positive rate for detection
of copy number variants, we developed three models: one Bayesian Anscombe normal approximation model for single genome, one Bayesian Poisson model for single
genome, and a Bayesian Anscome normal approximation model for paired genome.
The Bayesian statistics have been optimized for detection of change points and copy
numbers at single and multiple change points through Monte Carlo simulations. Three
R packages based on these models have been built up to simulate Poisson distribution data, estimate and display copy number variants in table and graphics. The high
sensitivity and specificity of these models have been demonstrated in simulated read
count data with known Poisson distribution and in human NGS read count data as
well in comparison to other popular packages.
Title from PDF of title page, viewed on June 8, 2015; Dissertation advisor: Jie Chen; Vita; Includes bibliographic references (pages 127-134); Thesis (Ph.D.)--Department of Mathematics and Statistics and School of Biological Sciences. University of Missouri--Kansas City, 2014
2014-01-01T00:00:00ZBerriBorowiec, Jeffrey Ryanhttps://hdl.handle.net/10355/434992016-07-14T17:47:18Z2014-07-17T00:00:00ZBerri
Borowiec, Jeffrey Ryan
Berri is a dramatic musical composition for large
chamber ensemble (Piccolo, Flute, Bb Clarinet, Bass Clarinet, 2 Violins, Viola, Cello, Bass, Piano, and Percussion) and narrator. The text for the narrator is an original one, drawing from the narratives and themes of Edgar Allen Poe’s short story “Berenice” and Taras Shevchenko’s poem “Katerina”. Berri is constructed in two large parts, each with seven
movements, along with an introductory “Toccata” and a
concluding “Epilogue”. The first part consists of a relatively straightforward exposition of the two chosen narratives, alternating between one and the other between movements. The music reflects this with primarily contrapuntal writing underscoring the Poe story, and more textural and abstract music beneath the Shevchenko poem. The main source for the musical language in Part I is an extended melodic line that appears first in its original form in the beginning of Movement IV - The Devil Jumped Over the Mountain.
In Part II, the narrator breaks into character (Egaeus, the main character from the Poe story), addresses the
audience in a dramatic role, and retells the narratives in a new and combined form, backwards. The music for this second part is more fluid and consistent in its ideas from one movement to the next. The primary source of melodic and harmonic material for Part II is the Epilogue, which is constructed from the melodies of three old Soviet/Communist propaganda songs.
The overall effect of the work is a dramatic and
musical arc that is nonlinear, and invites the listener to
form her own opinions on the nature of the narrative, the relationships of the characters involved, and any ultimate underlying message of the story being told
Title from PDF of title page, viewed on July 17, 2014; Thesis advisor: James Mobberley; Vita; Thesis (D. M. A.)--Division of Composition, Music Theory, Musicology and Dance. University of Missouri--Kansas City, 2014
2014-07-17T00:00:00Z