2014 MU dissertations - Access restricted to UMhttps://hdl.handle.net/10355/441442024-03-19T12:34:04Z2024-03-19T12:34:04ZAlternative translation and alternative RNA processing mechanism in parvovirus RNA processingFasina, Olufemihttps://hdl.handle.net/10355/459052022-09-27T19:08:07Z2014-01-01T00:00:00ZAlternative translation and alternative RNA processing mechanism in parvovirus RNA processing
Fasina, Olufemi
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Viruses as obligate intracellular metabolic parasite require the capacity to orchestrate and modulate the host environment either in the nucleus or cytoplasm for their efficient reproductive life cycle. This warrants the use of diverse range of proteins expressed from the viral genome with the ability of regulating viral genome replication, transcription and translation, in addition antagonizing host factors inhibitory to the virus. Therefore, in order to achieve these goals, viruses utilizes gene expression strategies to expand their coding capacity. Gene expression mechanism such as transcription initiation, capping, splicing and 3�-end processing afford viruses the opportunities to utilize the eukaryotic metabolic machineries for generating proteome diversity. Parvoviruses and other DNA viruses effectively capitalize on their use of nuclear eukaryotic metabolic machineries to co-opt host cell factors for optimal replication and gene expression. Parvoviruses with small genome size and overlapping open reading frames utilize alternative transcription initiation, alternative splicing and alternative polyadenylation to co-ordinate the expression of its non-structural and structural proteins. In this work, we have characterized how two parvoviruses; Dependovirus AAV5 and Bocavirus Minute virus of canine (MVC) utilize alternative gene expression mechanisms and strategies to optimize expression of viral proteins from their genome.
Abstract from public.pdf.
2014-01-01T00:00:00ZCafé, culture, and community : re-establishing a sense of place in Little Havana's Calle OchoIzsack, Vivian, 1962-https://hdl.handle.net/10355/442322022-09-29T20:34:25Z2014-01-01T00:00:00ZCafé, culture, and community : re-establishing a sense of place in Little Havana's Calle Ocho
Izsack, Vivian, 1962-
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The goal of this study is to identify how the built environment in Miami, Florida's Little Havana, specifically in the commercial corridor of 8th Street (or Calle Ocho) between 12th and 17th Avenues balances the customs of Cuba in times past with the present needs of a changing neighborhood--one that is more diverse but still appreciative of Hispanic, and specifically, Cuban customs. Aside from the commercial enclave, which effectively recreates opportunities to buy the comfort foods and items including clothing and specialty cigars, the people continue to use parks as a meeting place where many resurrect the customs and memories of their past. Three research questions drove this research: 1) What environmental attributes do people of Cuban descent use to re-establish a sense of place in Miami's Little Havana, 2) how do Calle Ocho merchants transform the formal, semi-formal, and informal gathering places along their commercial corridor to reflect culture, and 3) what are the similarities and/or dissimilarities among Calle Ocho's Latin cultures that allow them to share this space and call it their own? Data triangulation was used to verify the validity of this study. The sources were 15 Cubans ranging in age from 44 to 89 with time spent in the US ranging from 12 years to as little as three months. They were given disposable cameras and asked to photograph meaningful scenes from the Calle Ocho to discuss in recorded interviews. This research documents their assimilation and/or acculturation as well as their continued longing to keep a sense of their cultural heritage in place. The research is qualitative and captures rich description provided by accounts of immigrant experiences, memories, and impressions, showing the value of their heritage and the need to protect it.
"May 2014."; Dissertation Co-Supervisor: Benyamin Schwarz, Ph.D.; Ruth Brent Tofle, Ph.D.; Includes vita.
2014-01-01T00:00:00ZA case study of the integration of technology and instruction in a rural midwestern school districtBennett, Jane E.https://hdl.handle.net/10355/444562022-09-27T18:41:13Z2014-01-01T00:00:00ZA case study of the integration of technology and instruction in a rural midwestern school district
Bennett, Jane E.
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The purpose of this qualitative case study was to examine teachers' and administrators' perceptions of the integration of instruction and technology in a small Midwestern school district and to discover factors that impede or contribute to this process. A review of literature provides information on the importance of adhering to the principles of adult learning when delivering professional development for integrating technology and instruction to teachers. An examination of professional development practices found the needs of adult learners were not always considered during delivery. Literature about the knowing-doing gap revealed ways to assist teachers in adopting new processes with confidence and motivation, thus alleviating barriers to implementation. This study used semi-structured interviews with teachers, a focus group of administrators, document review, and observation with field notes to determine themes district leaders can use to understand how teachers and administrators view and experience professional development and practices concerning technology. The themes were: a) Integration of Technology and Instruction; (b) Professional Development; (c) Accountability; and (d) Barriers Contributing to the Knowing-Doing Gap. The findings provided district administration with implications for practice, which will allow teachers and leaders to develop a shared vision of the technological practices in the classroom and may aid in decisions regarding software, hardware, professional development, and level of support.
"July 2014."; Dissertation Supervisor: Dr. Carole Edmonds.; Includes vita.
2014-01-01T00:00:00ZChallenging national heterosexuality : a rhetorical analysis of campaign rhetoric for and against marriage equality in the November 2012 electionsCole, Hayley Jeannehttps://hdl.handle.net/10355/444822022-09-27T18:41:13Z2014-01-01T00:00:00ZChallenging national heterosexuality : a rhetorical analysis of campaign rhetoric for and against marriage equality in the November 2012 elections
Cole, Hayley Jeanne
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] This study analyzed the campaign appeals from the November 2012 campaigns for and against marriage equality. This study found that the campaigns against marriage equality appealed to their base voters in order to preserve and promote heteronormative understandings of marriage and ways of living. The campaigns for marriage equality, however, appealed to voters on all sides of the issue by encouraging conversations that challenged heteronormative understandings of marriage and society and promoted marriage and society as inclusive of LGBTQs. This study also found that there were two dominant narratives that competed against one another in 2012. The campaigns against marriage equality used a repressive narrative that framed marriage, family, religion, society, and individuals as exclusively heterosexual and ultimately aimed to put queers "in the closet." In contrast, the campaigns for marriage equality used a confessional narrative that challenged the repressive narrative by framing marriage, family, faith, citizenship, society, and individuals as inclusive of LGBTQs. Overall, the findings from this study describe how the message strategies and appeals by the campaigns for marriage equality were successful in persuading voters and ultimately winning at the ballot box in November 2012, by crafting messages that shaped public attitudes and shifted support in favor of marriage equality.
"July 2014."; Dissertation Supervisor: Dr. Mitchell S. McKinney.; Includes vita.
2014-01-01T00:00:00Z