Chemistry Department publications, presentations, and datasets (MU)https://hdl.handle.net/10355/68252024-03-29T00:14:24Z2024-03-29T00:14:24ZAdvanced Biomimetic Materials for Reversible CO2 Capture from Air [abstract]Glaser, Rainer, 1957-Yin, Jianhttps://hdl.handle.net/10355/12702020-06-19T19:30:08Z2009-01-01T00:00:00ZAdvanced Biomimetic Materials for Reversible CO2 Capture from Air [abstract]
Glaser, Rainer, 1957-; Yin, Jian
The world is rightly focused on climate change. The U.N. Intergovernmental Panel on Climate Change(IPCC) identified carbon capture and storage (CSS) as a critical technology for reducing emissions, not
only from power plants but also from industries that manufacture cement, chemicals and steel. The capture of CO2 from air and its long-term storage also presents the method of last resort to combat excessive atmospheric CO2 concentrations. IPPC concluded that the world has to reverse the increase of greenhouse gas emissions by 2020 to avert disastrous environment consequences. Modern societies largely rely on the fossil fuels to generate energy (electricity, heat, etc.) and as fuels
for transportation, and the principle mode of fossil fuel use involves its direct combustion to water and carbon dioxide. Efforts to reduce CO2 emissions are directed at improving the combustion efficiency
and/or at the development of technologies for carbon capture and storage (CCS). The fuel combustion efficiency depends on the type of fuel (coal, gaseous or liquid hydrocarbons, H2), the oxidizing agent
(air, O2-enriched air, stream), and combustion conditions (pres., temp., cat.). It is the primary aim of CCS technologies to capture CO2 at the source and its long-term storage. The 2007 MIT study “The Future of Coal” concluded that “CCS is the critical enabling technology that would reduce CO2
emissions significantly while also allowing coal to meet the world's pressing energy needs.” The three major approaches to CCS involve post-combustion scrubbing, oxyfuel, and pre-combustion decarbonization technologies. It is the goal of our research to develop advanced materials for CO2
scrubbing. Nature has evolved five pathways for autotrophic CO2 fixation and our approach is inspired by the mechanism of the photosynthetic carbon assimilation via the Calvin-Bassham-Benson cycle. The mechanism of the Rubisco-catalysis involves the activation by way of carbamylation of
active-site Lys by an activator CO2 (ACO2), and the carbamate thus formed is stabilized by complexation to Mg2+ and by NH...OC hydrogen-bonding. We present results of theoretical and mechanistic studies of
organic materials that mimic Rubisco's capacity for reversible CO2 capture and discuss the fixation of these materials on porous, solid supports to achieve large-scale CO2 scrubbing from ambient air.
Only abstract of poster available.; Track I: Power Generation
2009-01-01T00:00:00ZThe chemistry of NASCARKeller, S. W. (Steven W.)https://hdl.handle.net/10355/71782020-06-19T19:30:10Z2009-01-01T00:00:00ZThe chemistry of NASCAR
Keller, S. W. (Steven W.)
Associate professor in the Department of Chemistry in the College of Arts and Sciences at the University of Missouri-Columbia, Steven W. Keller, delivers a lecture on the chemistry of NASCAR, that is, the underlying chemical properties at work in car racing.
Video of presentation, 71 minutes
2009-01-01T00:00:00ZComparative oncology and clinical translation of glyco protein conjugated gold nano therapeutic agent (GA-198AuNP) [abstract]Kannan, RaghuramanKan, Para, 1980-Cutler, Cathy S.Jurisson, Silvia S. (Silvia Sabine)Katti, Kavita K.Chanda, NripenShukla, RaviAxiak, Sandra M.Lattimer, Jimmy C.Henry, Carolyn J.Zambre, AjitUpendran, AnandhiVolkert, Wynn A.Ketring, Alan R.Casteel, Stan W.Katti, Kattesh V.https://hdl.handle.net/10355/54942020-06-18T20:48:11Z2010-01-01T00:00:00ZComparative oncology and clinical translation of glyco protein conjugated gold nano therapeutic agent (GA-198AuNP) [abstract]
Kannan, Raghuraman; Kan, Para, 1980-; Cutler, Cathy S.; Jurisson, Silvia S. (Silvia Sabine); Katti, Kavita K.; Chanda, Nripen; Shukla, Ravi; Axiak, Sandra M.; Lattimer, Jimmy C.; Henry, Carolyn J.; Zambre, Ajit; Upendran, Anandhi; Volkert, Wynn A.; Ketring, Alan R.; Casteel, Stan W.; Katti, Kattesh V.
As part of our efforts toward clinical translation of GA-198AuNP, our studies are focused on therapeutic efficacy of nanoparticulate GA198AuNP agent in dogs with prostatic carcinoma. The overall goal is to gain clinical insights on therapeutic efficacy of GA198AuNP in a large animal model. We have performed a phase I clinical trial using GA-AuNP administered intravenously or intratumorally by injection or infusion. CT scans were performed prior to injection and 24 hours post injection in 3 of the 4 dogs. Following injections, dogs were allowed further treatment as recommended by the primary attending clinician. Four dogs have been treated to date. Complications related to GA-AuNP treatment were not observed, and all 4 dogs received adjunctive treatment with radiation therapy and/ or chemotherapy. These preliminary studies have clearly provided compelling evidence on the therapeutic potential of biocompatible GA-AuNP for their utility as novel therapeutic agents in treating various types of inoperable solid tumors. Intra-tumoral and intravenous administration of GA-AuNP is safe in dogs with spontaneously occurring tumors. As further therapeutic efficacy studies continue, the outcome of this clinical trial in a large animal model will generate therapeutic efficacy data which will be used for filing IND application for Phase I clinical trial studies. This clinical translation effort provides significant advances in terms of delivering optimum therapeutic payloads into prostate cancers with subsequent reduction in tumor volume, thus may effectively reduce/eliminate the need for surgical resection. This presentation will include details of clinical translation of GA198AuNP in prostate tumor bearing dogs.
Nanoscience Poster Session
2010-01-01T00:00:00ZComparative proteomic analysis unveils critical pathways underlying the role of Nitrogen fertilizer treatment in American elderberryYang, B.Thomas, A. L.Greenlief, C. M.https://hdl.handle.net/10355/745732022-12-14T16:49:57Z2019-01-01T00:00:00ZComparative proteomic analysis unveils critical pathways underlying the role of Nitrogen fertilizer treatment in American elderberry
Yang, B.; Thomas, A. L.; Greenlief, C. M.
American elderberry (Sambucus nigra subsp. canadensis) is a rapidly growing specialty crop in Missouri and eastern North America. Nitrogen (N) is a major nutrient involved in plant growth and development. However, proteome changes for different genotypes of elder in response to varying levels of N-treatment remain undefined. To reveal plant responses to N, comparative proteomic analyses were performed to determine consistent changes in three genotypes of elderberry leaves (Adams II, Bob Gordon and Wyldewood) grown under different N-fertilizer treatments. 165 proteins separated by two dimensional gel electrophoresis showed significant differences in abundance (p < 0.05 and greater than 2-fold). Principal component analysis of the abundance profiles of these proteins revealed Bob Gordon as a distinct genotype. The 165 proteins were identified by mass spectrometry and showed similar functional distributions in these genotypes underlying the N-treatment. Among the proteins identified, 23 are mainly involved in photosynthesis, protein metabolism and redox homeostasis. Their abundance profiles were not altered upon exposure to N or genotype. These results provide novel insights into plant responses to fertilizer treatment at the proteome level and could lead to a better understanding of molecular mechanisms of elderberry growth.
2019-01-01T00:00:00Z