Clinical Inquiries, 2005
https://hdl.handle.net/10355/3248
The items in this collection constitute volume 54 of Clinical Inquiries.2024-03-29T01:18:30ZAntiviral Agents for Pregnant Women with Genital Herpes
https://hdl.handle.net/10355/3948
Antiviral Agents for Pregnant Women with Genital Herpes
Wenner, Christopher; Nashelsky, Joan
There is no evidence that the use of antiviral agents in women who are pregnant and have a history of genital herpes prevents perinatal transmission of herpes simplex virus (HSV) to neonates. [Strength of recommendation: A, based on multiple systematic reviews] However, treatment with antivirals during the last month of pregnancy does reduce the rate of HSV outbreaks in pregnant women and the resultant need for cesarean delivery. [Strength of recommendation: A, based on multiple systematic reviews]
2005-01-01T00:00:00ZAre breast self-exams or clinical exams effective for screening breast cancer?
https://hdl.handle.net/10355/3249
Are breast self-exams or clinical exams effective for screening breast cancer?
Gaskie, Sean; Nashelsky, Joan
Breast self-examination has little or no impact on breast cancer mortality and cannot be recommended for cancer screening (strength of recommendation [SOR]: A, based on a systematic review of high-quality randomized, controlled trials [RCTs]). Clinical breast examination is an important means of averting some deaths from breast cancer, but demands careful attention to technique and thoroughness (SOR: B, extrapolating from a high-quality RCT).
2005-01-01T00:00:00ZCan type 2 diabetes be prevented through diet and exercise?
https://hdl.handle.net/10355/3251
Can type 2 diabetes be prevented through diet and exercise?
Warnken, Wayne; Kelsberg, Gary; Bryant, Sheila
Diets that result in long-term weight loss of 5% to 7%, along with moderate-intensity exercise for more than 150 minutes per week, reduce the incidence of type 2 diabetes for patients with impaired glucose tolerance (IGT) (strength of recommendation [SOR]: A, based on multiple randomized controlled trials [RCTs]). Each of the trials demonstrating this finding included fairly intensive counseling as part of the successful intervention. Diet and exercise reduce the incidence of diabetes in both lean (body mass index [BMI] <25) and overweight patients with IGT (SOR: B, based on a single, large RCT).
2005-01-01T00:00:00ZCan we prevent splenic rupture for patients with infectious mononucleosis?
https://hdl.handle.net/10355/3253
Can we prevent splenic rupture for patients with infectious mononucleosis?
Foreman, Brett H.; Mackler, Leslie
All patients with infectious mononucleosis should be considered at risk for splenic rupture since clinical severity, laboratory results, and physical exam are not reliable predictors of rupture (strength of recommendation [SOR]: B, case-control study). Clinical evidence indicates that most splenic ruptures occur within 4 weeks of symptom onset, which correlates with ultrasound data showing resolution of splenomegaly by 30 days from symptom onset (SOR: B, case-control study). Given the morbidity and mortality associated with splenic rupture, instruct patients to refrain from vigorous physical activity for 1 month after symptom onset (SOR: C, expert opinion).
2005-01-01T00:00:00Z