2016 Health Sciences Research Day (MU)
https://hdl.handle.net/10355/55713
2024-03-29T15:43:04ZAn accelerated mouse model of inflammatory dry eye disease
https://hdl.handle.net/10355/55720
An accelerated mouse model of inflammatory dry eye disease
Irlmeier, Rebecca; Wang, Lanlan; Reneker, Lixing W.
Meibomian glands (MGs) in eyelids (Fig. 1A) are enlarged sebaceous glands connected to hair follicles. The function of MGs is to secrete lipids which form the outer layer of the tear film of the eye (Fig. 1B). This layer maintains tear film stability by preventing tears from evaporating. Meibomian gland dysfunction (MGD) is a chronic abnormality of the Meibomian gland, commonly characterized by a change in the quantity or quality of the lipid secretion. MGD is among the most frequently diagnosed eye diseases and is a major cause of Dye Eye Disease (DED), but very little is known about the pathogenic processes leading to MGD and DED.
2016-01-01T00:00:00ZAssociations between comorbid disease outcomes among patients with depression in a student run free clinic
https://hdl.handle.net/10355/57177
Associations between comorbid disease outcomes among patients with depression in a student run free clinic
Brockmeyer, Jennifer; Cummings, John; Brandt, Kimberly; Duncan, Julie; Hayden, Gabrielle; Roderick, Margaret; Striegel, Sarah
Background: Research demonstrates a correlation between diagnosed depression and increased markers of chronic medical illness, including poorer glycemic control, increased risk for cardiovascular events, and obesity. Moreover, medically underserved patient populations are especially at high risk for poor health outcomes due to chronic illness, which has profound implications for both individual patients as well as the healthcare system. However, very little research has been done on chronic health outcomes among underserved mental health patients treated in integrated behavioral health/primary medical care settings. MedZou, a student-run, free medical clinic provides integrated health care services to uninsured, low-income adults in Mid-Missouri, and provides a potentially ideal setting for this research. We wanted to compare health outcomes between patients identified with depression and those without depression that were treated at MedZou.
2016-01-01T00:00:00ZAssociations between nutrient intake and gastrointestinal symptoms in autism spectrum disorder
https://hdl.handle.net/10355/55714
Associations between nutrient intake and gastrointestinal symptoms in autism spectrum disorder
Severns, D. S.; Ferguson, B. J.; Marler, S.; Altstein, L. L.; Lee, E. B.; Mazurek, M. O.; McLaughlin, A.; Hartnett, K.; Macklin, E. A.; McDonnell, E.; Davis, D. J.; Belenchia, A.; Gillespie, C. H.; Peterson, C. A.; Bauman, M. L.; Margolis, K. G.; Veenstra-VanderWeele, J.; Beversdorf, D. Q.
Many children and adolescents with autism spectrum disorder (ASD) have significant gastrointestinal (GI) symptoms, but the etiology is not well understood. Studies have shown conflicting evidence on whether there are nutritional deficiencies in the various diets of individuals with ASD. However, little is known about the relationship between dietary intake and GI symptomatology in ASD. The goal of the present study was to assess for potential relationships between GI symptoms and nutrient intake from diet in the same sample of individuals from the previous study, and to determine whether dietary differences might have contributed to our previously observed findings of a relationship between stress responses and GI functioning in ASD.
2016-01-01T00:00:00ZCan human xylosyltransferase-1 serve as a biomarker and therapeutic target for corneal fibrosis?
https://hdl.handle.net/10355/55718
Can human xylosyltransferase-1 serve as a biomarker and therapeutic target for corneal fibrosis?
Smith, Kaitlin E.; Tripathi, Ratnakar; Gupta, Suneel; Anumanthan, Govindaraj; Hesemann, Nathan P.; Mohan, Rajiv R.
Tested was the hypothesis that XYLT1 plays an important role in corneal wound healing and scarring and may allow development of newer strategies for curing corneal fibrosis. The specific aims were: 1) to characterize XYLT1 expression in normal and wounded human and rabbit corneas, 2) investigate its role in corneal wound healing, and 2) determine whether XYLT1 can serve as a biomarker for corneal fibrosis.
2016-01-01T00:00:00Z